This database reports actions of vasopressin or its analogs on physiological responses in kidney, culled from the literature. Please report additions or corrections to knep@helix.nih.gov. If there are any data that you would like to add to the database, please fill out this data submission form.The database was created by Akshay Sanghi, Matthew Zaringhalam, Fahad Saeed, Jason Hoffert, Pablo Sandoval, Trairak Pisitkun, and Mark Knepper in the Epithelial Systems Biology Laboratory of the National Heart, Lung and Blood Institute.    The data are presented in the form of 'triplets' consisting of 'subject', 'verb phrase', and 'direct object' in the first three columns. The direct objects are given as physiological responses. These triplets are equivalent to node-edge-node units in a directed graph. Additional columns indicate ancillary information that can be viewed as as prepositional phrases or parenthetical information. This triplet sentence structure is utilized to allow the database to be read either by humans or computers.    We produced complementary databases that describe the protein and physiological responses regulated by vasopressin:   Protein Targets Database   mRNA Targets Database Terminology: (click here) Download all data

Subject Verb (Action) Object Experimental System Percent of Control VP Dose Treatment Duration Reference AVP increases active calcium absorption in primary cultures of rabbit CCD to 150% (10 nM) (90 mins) (van Baal et al. , 1996) DDAVP increases active calcium absorption in primary cultures of rabbit CCD to 150% (10 nM) (90 mins) (van Baal et al. , 1996) AVP increases active potassium secretion in isolated perfused mineralocorticoid-treated rat CCD to 320% (0.1 nM) (0.5 hrs) (Tomita et al. , 1985) AVP increases active sodium absorption in isolated perfused mineralocorticoid-treated rat CCD to 460% (0.1 nM) (0.5 hrs) (Tomita et al. , 1985) AVP increases apical fluorescence of FM1-43 in isolated perfused rat IMCD to NA (0.1 nM) (30 min) (Yip et al., 2002) AVP increases bicarbonate flux (absorption) in isolated perfused CCD of DOC-treated rat to NA (0.1 nM) (0.5 hr) (Tomita et al. , 1986) AVP increases biocarbonate flux (absorption) in isolated perfused rat IMCD to 260% (10.0 nM) (8 mins) (Wall et al. , 1990) AVP increases cell height in isolated perfused Brattleboro rat IMCD to 120% (0.1 nM) (---) (Chou et al., 2004) AVP increases chloride flux (absorption) in isolated perfused mouse mTAL to 400% (250 μU/mL) (0.5 hr) (Hebert et al., 1981) AVP increases chloride flux (absorption) in isolated perfused mouse mTAL to 120% (2 μU/mL) (1 hr) (Sasaki et al., 1980) AVP increases chloride flux (absorption) in isolated perfused CCD of DOC-treated rat to 570% (0.1 nM) (0.5 hr) (Tomita et al. , 1986) AVP does not change chloride permeability in isolated perfused mouse mTAL to 100% (250 μU/mL) (1 hr) (Hebert et al., 1981) AVP does not change chloride permeability in isolated perfused rat terminal IMCD to 100% (10.0 nM) (---) (Sands et al., 1988) AVP increases choride flux (absorption) in isolated perfused mouse mTAL to 260% (100 μU/mL) (20 mins) (Hall et al., 1980) AVP increases diffusional water permeability in isolated perfused rabbit IMCD to 250% (2 μU/mL) (---) (Rocha et al. , 1982) AVP increases diffusional water permeability in isolated perfused guinea pig IMCD to 200% (2 μU/mL) (---) (Rocha et al. , 1982) AVP increases diffusional water permeability in isolated perfused human IMCD to 190% (2 μU/mL) (40 mins) (Rocha et al. , 1982) AVP increases diffusional water permeability in isolated perfused rat IMCD to 160% (2 μU/mL) (---) (Rocha et al. , 1982) AVP increases DNA synthesis in canine MDCK cells to 230% (100 nM) (40 hrs) (Reznik et al., 1985) AVP decreases DNA synthesis in primary culture of rabbit CCD to 80% (25 μU/mL) (24 hrs) (Wilson et al., 1983) AVP decreases DNA synthesis in primary culture of rabbit cTAL to 70% (25 μU/mL) (24 hrs) (Wilson et al., 1983) AVP decreases F-actin in subapical region of Brattleboro rat IMCD to NA (0.1 nM) (---) (Chou et al., 2004) AVP decreases F-actin in subapical region of Brattleboro rat IMCD to 70% (2.5 nM) (---) (Simon et al. , 1993) AVP increases fluid absorption in isolated perfused CCD of DOC-treated rat to 2790% (0.1 nM) (0.5 hr) (Tomita et al. , 1986) AVP increases H+-ATPase activity in cultured canine MDCK-C11 cells to 700% (1 nM) (7 mins) (Dos Santos et al., 2009) AVP increases H+-ATPase activity in cultured canine MDCK-C11 cells to 160% (0.01 nM) (---) (Dos Santos et al., 2009) AVP increases intracellular calcium in isolated perfused rat mTAL to 170% (1 nM) (4 min) (Burgess et al. , 1994) AVP increases intracellular calcium in rat IMCD suspensions to 110% (10 nM) (< 1min) (Chou et al., 1998) DDAVP increases intracellular calcium in rat IMCD suspensions to 110% (10 nM) (< 1min) (Chou et al., 1998) AVP increases intracellular calcium in isolated perfused rat IMCD to 120% (0.1 nM) (20 mins) (Chou et al., 2000) AVP increases intracellular calcium in primary cultures of rat IMCD to 210% (100 nM) (< 1 min) (Iskikawa et al., 1988) AVP does not change intracellular calcium in primary cultures of rat IMCD to 100% (1 nM) (< 1 min) (Iskikawa et al., 1988) AVP increases intracellular calcium in rat IMCD to 400% (100 nM) (0.5 min) (Mori et al., 2002) DDAVP increases intracellular calcium in rat IMCD suspensions to 230% (10 nM) (3 mins) (Pisitkun et al., 2008) DDAVP increases intracellular calcium in isolated perfused rat CCD to 160% (< 1 min) (10 nM) (Siga et al., 1994) AVP increases intracellular calcium in isolated perfused rat CCD to 250% (< 1 min) (10 nM) (Siga et al., 1994) AVP increases intracellular calcium in isolated perfused rat IMCD to 200% (10 nM) (2 mins) (Star et al., 1988) DDAVP increases intracellular calcium in isolated perfused rat IMCD to 170% (10 nM) (2 mins) (Star et al., 1988) AVP increases intracellular calcium in isolated perfused rat IMCD to 110% (0.1 nM) (2 mins) (Star et al., 1988) AVP increases intracellular calcium in isolated perfused rat IMCD to 280% (0.1 nM) (< 1 min) (Yip et al., 2002) AVP increases intracellular calcium in microdissected rat IMCD to 130% (10 nM) (1 min) (Ecelbarger et al., 1996) DDAVP increases intracellular calcium in cultured rat IMCD cells to 120% (10 nM) (1 min) (Ecelbarger et al., 1996) AVP increases intracellular calcium in isolated perfused mouse CCD to NA (10 nM) (---) (Odgaard et al., 2009) AVP increases intracellular calcium in pig LLC-PK1 cells to 1390% (1 μM) (1 min) (Tang et al., 1986) DDAVP increases intracellular calcium in pig LLC-PK1 cells to 280% (1 μM) (1 min) (Tang et al., 1986) AVP does not change intracellular calcium in pig LLC-PK1 cells to 100% (1 nM) (1 min) (Tang et al., 1986) AVP increases intracellular calcium oscillations in isolated perfused mouse mTAL to NA (10 nM) (---) (Odgaard et al., 2009) AVP increases intracellular cAMP in microdissected rat IMCD to 320% (0.1 nM) (40 mins) (Chou et al., 2000) AVP increases intracellular cAMP in microdissected rat cTAL to 610% (100 nM) (0.5 hr) (Imbert et al., 1975) AVP increases intracellular cAMP in microdissected rat CCD to 530% (0.1 nM) (0.5 hr) (Imbert et al., 1975) AVP increases intracellular cAMP in microdissected rat mTAL to 200% (1 nM) (0.5 hr) (Imbert et al., 1975) DDAVP increases intracellular cAMP in mouse mpkCCD to 2110% (1 nM) (0.5 hr) (Kortenoeven et al., 2012) DDAVP increases intracellular cAMP in mouse mpkCCD to 1210% (1 nM) (24 hrs) (Kortenoeven et al., 2012) DDAVP increases intracellular cAMP in mouse mpkCCD to 750% (1 nM) (96 hrs) (Kortenoeven et al., 2012) AVP increases intracellular cAMP in primary cultures of rat IMCD at 2,400 mOsm to 370% (10 nM) (5 mins) (Sato et al. , 1986) AVP increases intracellular cAMP in rat IMCD to 490% (10.0 nM) (2 mins) (Star et al., 1988) AVP increases intracellular cAMP in rat IMCD with IBMX to 300% (0.5 nM) (10 mins) (Star et al., 1988) AVP increases intracellular cAMP in rat IMCD to 200% (10.0 nM) (2 mins) (Star et al., 1988) DDAVP increases intracellular cAMP in rat IMCD to 200% (10.0 nM) (< 1 min) (Star et al., 1988) AVP increases intracellular cAMP in primary cultures of rat IMCD with IBMX to 700% (1 μM) (7 mins) (Teitelabaum et al., 1986) AVP does not change intracellular IP3 in rat IMCD suspensions to 100% (10 nM) (< 1min) (Chou et al., 1998) DDAVP does not change intracellular IP3 in rat IMCD suspensions to 100% (10 nM) (< 1min) (Chou et al., 1998) AVP increases intracellular IP3 in toad A6 cells to 170% (1 μM) (5 mins) (Hayslett et al., 1995) AVP increases intracellular nitric oxide in rat IMCD to 3430% (100 nM) (8 mins) (Mori et al., 2002) AVP does not change NH4+ flux in isolated perfused DOC-treated rat IMCD with chronic acid load to 100% (0.1 nM) (---) (Wall et al. , 1990) AVP increases nucleotide (ATP) secretion in isolated perfused mouse CCD to 2990% (10 nM) (---) (Odgaard et al., 2009) AVP increases nucleotide (ATP) secretion in isolated perfused mouse mTAL to 1970% (10 nM) (---) (Odgaard et al., 2009) AVP increases pH recovery rate in canine MDCK cells after acid load to 130% (1.0 nM) (2 mins) (Oliveria-Souza et al., 2001) DDAVP increases pH recovery rate in canine MDCK cells after acid load to 210% (1.0 nM) (2 mins) (Oliveria-Souza et al., 2004) AVP increases pH recovery rate in canine MDCK cells after acid load to 190% (1.0 nM) (2 mins) (Oliveria-Souza et al., 2004) DDAVP decreases prostaglandin E2 concentration in rat IMCD suspension with 50 µM ATP-γS to 60% (20 ng/hr) (144 hrs) (Sun et al., 2005) AVP increases prostaglandin E2 synthesis in microdissected rabbit CCD with 1 µM AA to 170% (1 nM) (10 mins) (Jaisser et al., 1989) DDAVP increases prostaglandin E2 synthesis in microdissected rabbit CCD with 1 µM AA to 120% (1 nM) (10 mins) (Jaisser et al., 1989) AVP does not change Protein Kinase C activity in rat IMCD suspensions to 100% (10 nM) (< 1min) (Chou et al., 1998) DDAVP does not change Protein Kinase C activity in rat IMCD suspensions to 100% (10 nM) (< 1min) (Chou et al., 1998) AVP does not change ratio of sodium over chloride permeability in isolated perfused rat terminal IMCD to 100% (10.0 nM) (---) (Sands et al., 1988) DDAVP increases snGFR in micropunctured Brattleboro rat to 110% (40 pg/min) (---) (Elalouf et al., 1984) AVP increases sodium absorption in isolated perfused rat IMCD to 920% (100 μU/mL) (1 hr) (Reif et al. , 1986) AVP increases sodium current in toad A6 cells to 980% (1 μM) (1 hr) (Hayslett et al., 1995) AVP increases sodium current in mouse mpkCCD with apical-amphotericin to 260% (10 nM) (1.5 hrs) (Michlig et al. , 2004) AVP does not change sodium permeability in isolated perfused mouse mTAL to 100% (250 μU/mL) (1 hr) (Hebert et al., 1981) AVP does not change transepithelial electrical resistance in isolated perfused rat terminal IMCD to 100% (10.0 nM) (---) (Sands et al., 1988) AVP decreases transepithelial electrical resistance in isolated perfused rat CCD to 90% (100 μU/mL) (< 1 min) (Schafer et al., 1990) AVP decreases transepithelial electrical resistance in primary cultures of rat IMCD to 60% (10 nM) (2 mins) (Mishler et al., 1990) AVP increases transepithelial voltage magnitude in isolated perfused mouse mTAL to 210% (250-1000 μU/mL) (20 mins) (Hall et al., 1980) AVP increases transepithelial voltage magnitude in isolated perfused mouse mTAL to 210% (250 μU/mL) (15 mins) (Hebert et al., 1981) AVP does not change transepithelial voltage magnitude in isolated perfused mouse cTAL to 110% (250 μU/mL) (1 hr) (Hebert et al., 1981) AVP increases transepithelial voltage magnitude in isolated perfused rat CCD to 460% (40-1000 μUnit/mL) (3 hrs) (Reif et al. , 1984) AVP increases transepithelial voltage magnitude in isolated perfused rat IMCD to 460% (100 μU/mL) (1 hr) (Reif et al. , 1986) AVP increases transepithelial voltage magnitude in isolated perfused mouse mTAL to 140% (200 μU/mL) (10 mins) (Sasaki et al., 1980) AVP increases transepithelial voltage magnitude in isolated perfused CCD of DOC-treated rat to 280% (100 μU/mL) (5 mins) (Schafer et al., 1987) AVP increases transepithelial voltage magnitude in isolated perfused rat CCD to 260% (100 μU/mL) (< 1 min) (Schafer et al., 1990) AVP increases transepithelial voltage magnitude in isolated perfused mineralocorticoid-treated rat CCD to 250% (0.1 nM) (0.5 hrs) (Tomita et al. , 1985) AVP increases transepithelial voltage magnitude in isolated perfused CCD of DOC-treated rat to 250% (0.1 nM) (0.5 hr) (Tomita et al. , 1986) AVP increases unidirectional choride36 flux (absorption) in isolated perfused mouse mTAL to 250% (100 μU/mL) (20 mins) (Hall et al., 1980) AVP decreases unidirectional rubidium86 flux (absorption) in isolated perfused CCD of DOC-treated rat to 40% (100 μU/mL) (20 mins) (Schafer et al., 1987) AVP increases unidirectional rubidium86 flux (absorption) in isolated perfused CCD of DOC-treated rat to 260% (100 μU/mL) (20 mins) (Schafer et al., 1987) AVP increases unidirectional sodium22 flux (absorption) in isolated perfused CCD of DOC-treated rat to 170% (100 μU/mL) (20 mins) (Schafer et al., 1987) AVP increases urea permeability in isolated perfused mouse IMCD to 370% (0.1 nM) (---) (Fenton et al., 2004) AVP increases urea permeability in IMCD of isolated rat papilla to 150% (200 μU/mL) (---) (Morgan et al. , 1968) AVP increases urea permeability in canine MDCK-UT-A2 cells to 150% (0.3 nM) (0.5 hr) (Potter et al., 2006) AVP increases urea permeability in canine MDCK-UT-A2 cells to 140% (0.1 nM) (0.5 hr) (Potter et al., 2006) AVP does not change urea permeability in canine MDCK-UT-A1 cells to 100% (10 nM) (0.5 hr) (Potter et al., 2006) AVP increases urea permeability in isolated perfused human CD to 350% (2 μU/mL) (40 mins) (Rocha et al. , 1982) AVP increases urea permeability in isolated perfused rat IMCD to 260% (2 μU/mL) (---) (Rocha et al. , 1982) AVP does not change significantly urea permeability in isolated perfused guinea pig IMCD to 140% (2 μU/mL) (---) (Rocha et al. , 1982) AVP does not change urea permeability in isolated perfused rabbit IMCD to 100% (2 μU/mL) (---) (Rocha et al. , 1982) AVP increases urea permeability in isolated perfused rat IMCD to 400% (10 nM) (0.5 hr) (Sands et al., 1998) AVP increases urea permeability in isolated perfused hypercalcemic rat IMCD to 140% (10 nM) (0.5 hr) (Sands et al., 1998) AVP increases urea permeability in isolated perfused rat IMCD to 320% (0.01 nM) (40 mins) (Star et al., 1988) AVP increases water permeability in isolated perfusesd rat IMCD to 320% (0.1 nM) (---) (Chou et al., 2000) AVP increases water permeability in isolated perfused Brattleboro rat IMCD to 460% (0.1 nM) (---) (Chou et al., 2004) AVP increases water permeability in isolated perfused untreated Brattleboro rat IMCD to 610% (0.2 nM) (0.5 hr) (DiGiovanni et al., 1994) AVP increases water permeability in isolated perfused AVP-treated Brattleboro rat IMCD to 260% (0.2 nM) (0.5 hr) (DiGiovanni et al., 1994) AVP increases water permeability in isolated perfused IMCD from Brattleboro rat to 250% (21 ng/hr) (120 hrs) (DiGiovanni et al., 1994) AVP increases water permeability in isolated perfused rabbit CCD to 320% (250 μU/mL) (20 mins) (Grantham et al., 1966) AVP increases water permeability in isolated perfused rat IMCD to 460% (0.1 nM) (40 mins) (Han et al., 1993) AVP increases water permeability in IMCD of isolated rat papilla to 200% (200 μU/mL) (---) (Morgan et al. , 1968) AVP increases water permeability in isolated perfused rat IMCD to 530% (0.1 nM) (40 mins) (Nielsen et al. , 1995) AVP increases water permeability in isolated perfused rat CCD to 5570% (40-1000 μUnit/mL) (3 hrs) (Reif et al. , 1984) AVP increases water permeability in isolated perfused rat IMCD to 400% (0.1 nM) (0.5 hr) (Sands et al., 1998) AVP does not change water permeability in isolated perfused hypercalcemic rat IMCD to 100% (0.1 nM) (0.5 hr) (Sands et al., 1998) AVP increases water permeability in isolated perfused rabbit CCD to 1390% (2 μU/mL) (1 hr) (Sasaki et al., 1980) AVP does not change water permeability in isolated perfused mouse mTAL to 100% (2 μU/mL) (1 hr) (Sasaki et al., 1980) AVP does not change water permeability in isolated perfused rat mTAL to 100% (2 μU/mL) (1 hr) (Sasaki et al., 1980) AVP increases water permeability in isolated perfused rat IMCD to 320% (0.01 nM) (40 mins) (Star et al., 1988) AVP increases water permeability in isolated perfused rat IMCD to 320% (0.01 nM) (40 mins) (Star et al., 1988)

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