National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Primary Cilium Proteome Database

This database shows proteins identified in primary cilia of mouse IMCD3 cells, compiled from three different proteomic publications:

1. Biochemical isolation using calcium-shock. Ishikawa, H., Thompson, J., Yates III, J. R., & Marshall, W. F. (2012). Proteomic Analysis of Mammalian Primary Cilia. Current Biology, 22, 414-419. PMID: 22326026
2. Proximity labeling using cilia-APEX (NPHP3-APEX). Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gyri, S. P., Nachury, M. V. (2015). Proteomics of Primary Cilia by Proximity Labeling. Developmental Cell, 35(4), 497-512. PMID: 26585297
3. Proximity labeling using cilia-APEX2 (NPHP3-APEX2). May EA, Kalocsay M, D'Auriac IG, Schuster PS, Gygi SP, Nachury MV, Mick DU. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol. 2021;220(5):e202007207. PMID: 33856408

The full mouse IMCD3 transcriptome is viewable here. Database was created by Yash Mehta, Spencer Lewis, Kirby Leo, Vishwanathan Raghuram and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project. The protein descriptor information was compiled using the Automated Bioinformatics Extractor (ABE). Click to download data as spreadsheet. Please cite: Mehta et al., 2022. PMID:34757121.

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Primary Cilium Proteome

Gene Symbol Annotation Ishikawa et al.  Mick et al.  May et al. Descriptor
Abce1 ATP-binding cassette sub-family E member 1 Yes No No Translation
Abraxas2 BRISC complex subunit Abraxas 2 No Yes No Microtubule Cytoskeleton
Acaca acetyl-CoA carboxylase 1 Yes No No Metabolic Enzyme
Actc1 actin, alpha cardiac muscle 1 No Yes No Actin Cytoskeleton
Actn1 alpha-actinin-1  No Yes No Actin Cytoskeleton
Actn4 alpha-actinin-4  No Yes No Actin Cytoskeleton
Adcy6 adenylate cyclase type 6  No Yes No Cyclic AMP Generation
Adpgk ADP-dependent glucokinase   Yes No No Metabolic Enzyme
Adss adenylosuccinate synthetase isozyme 2 No No Yes Metabolic Enzyme
Ahi1 jouberin  No No Yes Cilium Structure
Aldh18a1 delta-1-pyrroline-5-carboxylate synthase  Yes No No Metabolic Enzyme
Anks6 ankyrin repeat and SAM domain-containing protein 6  No No Yes Cilium Structure
Anp32e acidic leucine-rich nuclear phosphoprotein 32 family member E  Yes No No Vesicle Transport
Anxa11 annexin A11 No Yes Yes Vesicle Transport
Anxa3 annexin A3 No No Yes Vesicle Transport
Anxa6 annexin A6  No Yes No Vesicle Transport
Anxa7 annexin A7  No Yes Yes Vesicle Transport
Ap2b1 AP-2 complex subunit beta  Yes No No Vesicle Transport
App amyloid-beta A4 protein   No Yes No Protein Folding
Arf4 ADP-ribosylation factor 4 Yes No No Vesicle Transport
Arf6 ADP-ribosylation factor 6 Yes No No Vesicle Transport
Arfgef1 brefeldin A-inhibited guanine nucleotide-exchange protein 1 Yes No No Small GTPase Binding
Arhgap1 rho GTPase-activating protein 1  No Yes No Small GTPase Binding
Arhgap5 rho GTPase-activating protein 5 Yes No No Small GTPase Binding
Arhgef18 rho guanine nucleotide exchange factor 18  No Yes No Small GTPase Binding
Arl13b ADP-ribosylation factor-like protein 13B Yes Yes Yes GTPase activity
Arl3 ADP-ribosylation factor-like protein 3  Yes Yes Yes GTPase activity
Arl6 ADP-ribosylation factor-like protein 6  No Yes No GTPase activity
Armc9 lisH domain-containing protein ARMC9  No Yes Yes Cilium Structure
Arpc3 actin-related protein 2/3 complex subunit 3 Yes No No Actin Cytoskeleton
Arpp19 cAMP-regulated phosphoprotein 19  No No Yes Protein Phosphatase Regulation
Atp6v1a V-type proton ATPase catalytic subunit A No Yes No Metabolic Enzyme
Axl tyrosine-protein kinase receptor UFO   No Yes No Protein Kinase
Bag3 BAG family molecular chaperone regulator 3 No No Yes Protein Folding
Bag4 BAG family molecular chaperone regulator 4 No No Yes Protein Folding
Bbs1 Bardet-Biedl syndrome 1 protein homolog No No Yes Cilium Structure
Bbs2 Bardet-Biedl syndrome 2 protein homolog No No Yes Cilium Structure
Bbs4 Bardet-Biedl syndrome 4 protein homolog  No No Yes Cilium Structure
Bbs5 Bardet-Biedl syndrome 5 protein homolog  No No Yes Cilium Structure
Bbs7 Bardet-Biedl syndrome 7 protein homolog No No Yes Cilium Structure
Bbs9 protein PTHB1  No No Yes Cilium Structure
Blnk B-cell linker protein  No No Yes Protein Kinase Regulation
Btf3 transcription factor BTF3  Yes No No Transcription Factor
Cab39 calcium-binding protein 39 No No Yes Protein Kinase Regulation 
Calr calreticulin  No Yes No Protein Folding
Calu calumenin  Yes No No Protein Modification
Camk2d calcium/calmodulin-dependent protein kinase type II subunit delta  Yes No No Protein Kinase
Capg macrophage-capping protein No Yes Yes Actin Cytoskeleton
Capn2 calpain-2 catalytic subunit Yes Yes No Mitochondrial Protein
Capzb F-actin-capping protein subunit beta  No Yes No Protein Kinase Regulation 
Cbl E3 ubiquitin-protein ligase CBL No No Yes Ubiquitination
Cc2d2a coiled-coil and C2 domain-containing protein 2A  No No Yes Transition Zone of Primary Cilium
Ccdc181 coiled-coil domain-containing protein 181 No No Yes Microtubule Cytoskeleton
Ccdc47 PAT complex subunit CCDC47  Yes Yes No Protein Folding
Ccdc50 coiled-coil domain-containing protein 50  No No Yes Microtubule Cytoskeleton
Ccdc66 coiled-coil domain-containing protein 66 No Yes Yes Cilium Structure
Cct4 T-complex protein 1 subunit delta Yes No No Protein Folding
Cct5 T-complex protein 1 subunit epsilon  Yes No No Protein Folding
Cct6a T-complex protein 1 subunit zeta Yes No No Protein Folding
Cct8 T-complex protein 1 subunit theta Yes No No Protein Folding
Cd151 CD151 antigen No Yes No Tetraspanin
Cd81 CD81 antigen No Yes Yes Vesicle Transport
Cd82 CD82 antigen No Yes No Tetraspanin
Cd9 CD9 antigen No Yes No Tetraspanin
Cd99l2 CD99 antigen-like protein 2   No Yes No Cell Adhesion
Cdc42 cell division control protein 42 homolog  No Yes No Vesicle Transport
Cdh16 cadherin-16  No Yes No Cell-Cell Adhesion
Cdk1 cyclin-dependent kinase 1 Yes No No Protein Kinase
Cdk20 cyclin-dependent kinase 20 No No Yes Protein Kinase
Cdv3 protein CDV3  No No Yes ?
Cemip2 cell surface hyaluronidase Yes Yes Yes Extracellular Matrix Regulator
Cep104 centrosomal protein of 104 kDa No No Yes Cilium Structure
Cep131 centrosomal protein of 131 kDa Yes Yes Yes Cilium Structure
Cep290 centrosomal protein of 290 kDa No No Yes Cilium Structure
Cep41 centrosomal protein of 41 kDa Yes Yes Yes Cilium Structure
Cep97 centrosomal protein of 97 kDa  No No Yes Cilium Structure
Cfap20 cilia- and flagella-associated protein 20 Yes Yes No Cilium Structure
cfap36 cilia- and flagella-associated protein 36 No No Yes Cilium Structure
Cfap97 cilia- and flagella-associated protein 97 No Yes No Cilium Structure
Chchd2 coiled-coil-helix-coiled-coil-helix domain-containing protein 2  No No Yes Regulation of Transcription
Chd6 chromodomain-helicase-DNA-binding protein 6 No No Yes Helicase Activity
Chmp4b charged multivesicular body protein 4b Yes No Yes Multivesicular Body
Chp1 calcineurin B homologous protein 1 Yes No No Protein Kinase Regulation 
Ciapin1 anamorsin No No Yes Mitochondrial Protein
Ckap2 cytoskeleton-associated protein 2 No Yes Yes Microtubule Cytoskeleton
Ckap2l cytoskeleton-associated protein 2-like No Yes Yes Microtubule Cytoskeleton
Ckap5 cytoskeleton-associated protein 5  No Yes No Microtubule Cytoskeleton
Clasp1 CLIP-associating protein 1  No Yes No Vesicle Transport
Cluap1 clusterin-associated protein 1 Yes No Yes Smoothened/Hedgehog Signaling 
Cnn3 calponin-3 Yes No No Actin Cytoskeleton
Cnp 2',3'-cyclic-nucleotide 3'-phosphodiesterase  Yes No No Microtubule Cytoskeleton
Cog4 conserved oligomeric Golgi complex subunit 4  Yes No No Vesicle Transport
comt catechol O-methyltransferase Yes No No Metabolic Enzyme
Copb2 coatomer subunit beta' Yes No No Vesicle Transport
Coro1b coronin-1B No Yes No Protein Kinase Regulation 
Cpne3 copine-3  No No Yes Mitochondrial Protein
Crk adapter molecule crk  No No Yes Actin Cytoskeleton
Cse1l exportin-2 Yes No No Small GTPase Binding
Csnk1e casein kinase I isoform epsilon  No Yes No Protein Kinase
Cspp1 centrosome and spindle pole associated protein 1  No Yes Yes Microtubule Cytoskeleton
Cstb cystatin-B No Yes No Protease Inhibitor
Ctnna1 catenin alpha-1 No Yes No Actin Cytoskeleton
Cul2 cullin-2 Yes No No Ubiquitination
Cyp51a1 Lanosterol 14-alpha demethylase No Yes No Metabolic Enzyme
Cyrib CYFIP-related Rac1 interactor B  Yes No No Small GTPase Binding
Cys1 cystin-1 Yes Yes Yes Regulation of Transcription
Daam1 disheveled-associated activator of morphogenesis 1  Yes No No Small GTPase Binding
Dcdc2a doublecortin domain-containing protein 2  Yes No No Wnt Signaling
Dctn2 dynactin subunit 2  Yes No No Vesicle Transport
Ddx1 ATP-dependent RNA helicase DDX1 No Yes No Helicase Activity
Ddx21 nucleolar RNA helicase 2 No Yes No Helicase Activity
Dhx30 ATP-dependent RNA helicase DHX30  Yes No No Helicase Activity 
Dhx36 ATP-dependent DNA/RNA helicase DHX36 No No Yes Helicase Activity
Diaph1 protein diaphanous homolog 1  Yes No No Small GTPase Binding
Dnm1l dynamin-1-like protein  Yes No No Vesicle Transport
Dnm2 dynamin-2  Yes No No Cilium Structure
Dpysl2 dihydropyrimidinase-related protein 2  No Yes Yes Vesicle Transport
Drg1 developmentally-regulated GTP-binding protein 1 Yes No No GTPase activity
Drg2 developmentally-regulated GTP-binding protein 2 Yes No No GTPase activity
Dsc2 desmocollin-2  No No Yes Vesicle Transport
Dsg2 desmoglein-2 preproprotein No Yes No Cell-Cell Adhesion
Dvl3 segment polarity protein dishevelled homolog DVL-3  No Yes No Wnt Signaling
Dync1h1 cytoplasmic dynein 1 heavy chain 1 Yes No No Vesicle Transport
Dync1li1 cytoplasmic dynein 1 light intermediate chain 1 Yes No No Microtubule Cytoskeleton
Dync2h1 cytoplasmic dynein 2 heavy chain 1  Yes No Yes Microtubule Cytoskeleton
Dync2i1 cytoplasmic dynein 2 intermediate chain 1 No Yes No Microtubule Cytoskeleton
Dync2li1 cytoplasmic dynein 2 light intermediate chain 1 Yes No Yes Cilium Structure
Dyrk2 dual specificity tyrosine-phosphorylation-regulated kinase 2 No No Yes Protein Kinase
Edc4 enhancer of mRNA-decapping protein 4  Yes No No RNA Bindiing
Eef1d elongation factor 1-delta  Yes No No Translation
Efcab7 EF-hand calcium-binding domain-containing protein 7 Yes No Yes Regulation of Transcription
Eif2a eukaryotic translation initiation factor 2A No Yes Yes Translation
Eif2d eukaryotic translation initiation factor 2D  No No Yes Translation
Eif2s2 eukaryotic translation initiation factor 2 subunit 2 Yes No No Translation
Eif3b eukaryotic translation initiation factor 3 subunit B Yes No No Translation
Eif3l eukaryotic translation initiation factor 3 subunit L Yes No No Translation
Eif4b eukaryotic translation initiation factor 4B No Yes Yes Translation
Eif4g1 eukaryotic translation initiation factor 4 gamma 1  Yes No No Translation
Eif4h eukaryotic translation initiation factor 4H  Yes No Yes Translation
Eif5a eukaryotic translation initiation factor 5A-1 No Yes No Translation
Eif5b eukaryotic translation initiation factor 5B Yes No No Translation
Elp4 elongator complex protein 4 No Yes No Lysine Acetyltransferase
Enkd1 enkurin domain-containing protein 1 No No Yes Microtubule Cytoskeleton
Env MLV-related proviral Env polyprotein No Yes No ?
Epb41l2 band 4.1-like protein 2  Yes No No Actin Cytoskeleton
Epb41l3 band 4.1-like protein 3  No Yes No Actin Cytoskeleton
Eps15l1 epidermal growth factor receptor substrate 15-like 1  Yes No No Vesicle Transport
Eps8l2 epidermal growth factor receptor kinase substrate 8-like protein 2 No Yes No Cilium Structure
Erbin erbin  Yes No No Regulation of Transcription
Etfb electron transfer flavoprotein subunit beta Yes No No Mitochondrial Protein
Evc ellis-van Creveld syndrome protein homolog No Yes Yes Smoothened/Hedgehog Signaling 
Evc2 limbin  Yes Yes Yes Smoothened/Hedgehog Signaling 
Ezr ezrin No Yes No Actin Cytoskeleton
Fam114a2 protein FAM114A2  Yes No No ?
Fam179b TOG array regulator of axonemal microtubules protein 1 No No Yes Microtubule Cytoskeleton
Fkbp1a peptidyl-prolyl cis-trans isomerase FKBP1A  No No Yes Protein Phosphatase Regulation
Fkbp5 peptidyl-prolyl cis-trans isomerase FKBP5 No Yes No Metabolic Enzyme
Fkbp8 peptidyl-prolyl cis-trans isomerase FKBP8  No Yes No Metabolic Enzyme
Flii protein flightless-1 homolog  Yes No No Actin Cytoskeleton
Fxyd5 FXYD domain-containing ion transport regulator 5   No Yes No Ion Transport
G3bp1 ras GTPase-activating protein-binding protein 1 Yes No No Helicase Activity
Gart trifunctional purine biosynthetic protein adenosine-3 Yes No No Metabolic Enzyme
Gbf1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1  Yes No No Vesicle Transport
Gdi2 rab GDP dissociation inhibitor beta No Yes No Vesicle Transport
Get3 ATPase GET3  Yes No No Endoplasmic Reticulum
Glis3 zinc finger protein GLIS3  No Yes No Transcription Factor
Glod4 glyoxalase domain-containing protein 4  No Yes No Mitochondrial Protein
Glrx3 glutaredoxin-3  No Yes Yes Protein Kinase Regulation 
Gnas heterotrimeric G-protein stimulatory alpha subunit Yes No No Cyclic AMP Generation
Gpc1 glypican-1  No Yes No Extracellular Matrix Regulator
Gpi glucose-6-phosphate isomerase No Yes No Metabolic Enzyme
Gpr161 G-protein coupled receptor 161  No No Yes GPCR
Gsto1 glutathione S-transferase omega-1 No No Yes Metabolic Enzyme
Gtl3 cilia and flagella associated protein 20 No No Yes Cilium Structure
Hars histidine--tRNA ligase, cytoplasmic Yes No No Translation
Hgs hepatocyte growth factor-regulated tyrosine kinase substrate  No No Yes Vesicle Transport
Hnrnpk heterogeneous nuclear ribonucleoprotein K  Yes No No RNA Bindiing
Hnrnpll heterogeneous nuclear ribonucleoprotein L-like No Yes No RNA Bindiing
Hspa1l heat shock 70 kDa protein 1-like Yes No No Protein Folding
Hspa4 heat shock 70 kDa protein 4 Yes No No Protein Folding
Hspb1 heat shock protein beta-1 Yes No No Protein Folding
Hspb11 intraflagellar transport protein 25 homolog Yes No No Cilium Structure
Hsph1 heat shock protein 105 kDa  Yes No No Protein Folding
Ick serine/threonine-protein kinase ICK No No Yes Protein Kinase
Ide insulin-degrading enzyme Yes Yes No Metabolic Enzyme
Idh1 isocitrate dehydrogenase [NADP] cytoplasmic Yes No No Metabolic Enzyme
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 Yes No No RNA Bindiing
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 Yes No No RNA Bindiing
Ift122 intraflagellar transport protein 122 homolog  Yes Yes Yes Cilium Structure
Ift140 intraflagellar transport protein 140 homolog Yes No Yes Cilium Structure
Ift172 intraflagellar transport protein 172 homolog Yes Yes Yes Cilium Structure
Ift20 intraflagellar transport protein 20 homolog Yes No No Cilium Structure
Ift22 intraflagellar transport protein 22 homolog Yes No Yes Cilium Structure
Ift27 intraflagellar transport protein 27 homolog Yes No No Cilium Structure
Ift43 intraflagellar transport protein 43 homolog  No No Yes Cilium Structure
Ift46 intraflagellar transport protein 46 homolog Yes No Yes Cilium Structure
Ift52 intraflagellar transport protein 52 homolog Yes Yes Yes Cilium Structure
Ift57 intraflagellar transport protein 57 homolog Yes Yes Yes Cilium Structure
Ift74 intraflagellar transport protein 74 homolog  Yes Yes Yes Cilium Structure
Ift80 intraflagellar transport protein 80 homolog Yes No Yes Cilium Structure
Ift81 intraflagellar transport protein 81 homolog  Yes Yes Yes Cilium Structure
Ift88 intraflagellar transport protein 88 homolog Yes Yes Yes Cilium Structure
Igbp1 immunoglobulin-binding protein 1 No No Yes Protein Phosphatase Regulation
Impdh2 inosine-5'-monophosphate dehydrogenase 2  No Yes No Metabolic Enzyme
Inpp5e phosphatidylinositol polyphosphate 5-phosphatase type IV  Yes Yes Yes Lipid Phosphatase
Invs inversin  Yes No Yes Microtubule Cytoskeleton
Ipo5 importin-5  Yes No No Nuclear Transport
Ipo7 importin-7  Yes No No Nuclear Transport
Iqce IQ domain-containing protein E  No Yes Yes Regulation of Transcription
Islr immunoglobulin superfamily containing leucine-rich repeat protein  No Yes No ?
Ist1 IST1 homolog  No No Yes Vesicle Transport
Isyna1 inositol-3-phosphate synthase 1 No Yes No Metabolic Enzyme
Jpt2 jupiter microtubule associated homolog 2 No Yes Yes Microtubule Cytoskeleton
Kcnab2 voltage-gated potassium channel subunit beta-2  No No Yes Microtubule Cytoskeleton
Kiaa1430 cilia- and flagella-associated protein 97 Yes Yes Yes Cilium Structure
Kif1b kinesin-like protein KIF1B  No Yes No Vesicle Transport
Kif22 kinesin-like protein KIF22 No Yes No Microtubule Cytoskeleton
Kif2a kinesin-like protein KIF2A  No Yes Yes Microtubule Cytoskeleton
Kif3a kinesin-like protein KIF3A  Yes Yes Yes Microtubule Cytoskeleton
Kif3b kinesin-like protein KIF3B Yes Yes Yes Microtubule Cytoskeleton
Kif3c kinesin-like protein KIF3C No No Yes Vesicle Transport
Kif7 kinesin-like protein KIF7  No No Yes Microtubule Cytoskeleton
Kifap3 kinesin-associated protein 3 isoform KAP3A Yes Yes Yes Microtubule Cytoskeleton
Kpna2 importin subunit alpha-1 Yes No No Nuclear Transport
Lamb1 laminin subunit beta-1  Yes No No Cell Adhesion
Lancl2 lanC-like protein 2 No Yes No Regulation of Transcription
Lasp1 LIM and SH3 domain protein 1 No No Yes Actin Cytoskeleton
Lca5 lebercilin  Yes Yes Yes Cilium Structure
Ldhb L-lactate dehydrogenase B chain  No Yes No Metabolic Enzyme
Lgals3 galectin-3 No Yes Yes Lectin
Lpp lipoma-preferred partner homolog  No No Yes Cell-Cell Adhesion
Lrrc40 leucine-rich repeat-containing protein 40  Yes No No ?
Lrrc59 leucine-rich repeat-containing protein 59 Yes No No Mitochondrial Protein
Lrrc8b volume-regulated anion channel subunit LRRC8B No No Yes Volume-Regulated Anion Channel
Lrrc8e volume-regulated anion channel subunit LRRC8E No No Yes Volume-Regulated Anion Channel
Lztfl1 leucine zipper transcription factor-like protein 1 No No Yes Transcription Factor
Macf1 microtubule-actin cross-linking factor 1  Yes No No Actin Cytoskeleton 
Map1s microtubule-associated protein 1S Yes No No Microtubule Cytoskeleton
Map4 microtubule-associated protein 4  No Yes Yes Microtubule Cytoskeleton
Map7d1 MAP7 domain-containing protein 1  No No Yes Microtubule Cytoskeleton
Mapre1 microtubule-associated protein RP/EB family member 1 No Yes Yes Cilium Structure
Mapre3 microtubule-associated protein RP/EB family member 3  No No Yes Protein Kinase Regulation 
Mcam cell surface glycoprotein MUC18   No Yes No Mucin
Mcm4 DNA replication licensing factor MCM4 Yes No No Helicase Activity
Mdm1 nuclear protein MDM1  No No Yes Microtubule Cytoskeleton
Mtcl1 microtubule cross-linking factor 1  No No Yes Microtubule Cytoskeleton
Mtnd4l NADH-ubiquinone oxidoreductase chain 4L No Yes No Metabolic Enzyme
Mttp microsomal triglyceride transfer protein large subunit   No Yes No Vesicle Transport
Mycbp2 E3 ubiquitin-protein ligase MYCBP2 No Yes No Ubiquitination
Myo1c unconventional myosin-Ic  No Yes No Actin Cytoskeleton
N4bp1 NEDD4-binding protein 1 No No Yes Ubiquitination
Naca nascent polypeptide-associated complex subunit alpha  Yes No No Regulation of Transcription
Napg gamma-soluble NSF attachment protein No No Yes Vesicle Transport
Ncl nucleolin Yes No No Regulation of Transcription
Ncln nicalin  Yes No No Endoplasmic Reticulum
Nedd4l E3 ubiquitin-protein ligase NEDD4-like  No Yes No Ubiquitination
Nek8 serine/threonine-protein kinase Nek8 Yes No Yes Protein Kinase
Nme1 nucleoside diphosphate kinase A No Yes No Metabolic Enzyme
Nme7 nucleoside diphosphate kinase 7  Yes Yes Yes Metabolic Enzyme
Nphp1 nephrocystin-1  No No Yes Cilium Structure
Nphp3 nephrocystin-3  Yes No Yes Cilium Structure
Nrd1 nardilysin   Yes No No Metabolic Enzyme
Nsfl1c NSFL1 cofactor p47  No No Yes Vesicle Transport
Nudcd1 nudC domain-containing protein 1  Yes No No ?
Ogdh 2-oxoglutarate dehydrogenase, mitochondrial   Yes No No Metabolic Enzyme
Osbpl3 oxysterol-binding protein-related protein 3  Yes No No Phospholipid Binding
Oscp1 protein OSCP1  No No Yes Organic Ion Transport
P4ha1 prolyl 4-hydroxylase subunit alpha-1   No Yes No Metabolic Enzyme
Pa2g4 proliferation-associated protein 2G4 Yes No No Regulation of Transcription
Pak2 serine/threonine-protein kinase PAK 2 Yes No No Protein Kinase
Palld palladin  No No Yes Actin Cytoskeleton
Pawr PRKC apoptosis WT1 regulator protein No No Yes Protein Phosphatase Regulation
Pax8 paired box protein Pax-8 No Yes No Transcription Factor
Pbk lymphokine-activated killer T-cell-originated protein kinase No Yes No Protein Kinase
Pdap1 28 kDa heat- and acid-stable phosphoprotein Yes Yes Yes ?
Pdia3 protein disulfide-isomerase A3  Yes No No Mitochondrial Protein
Pdlim5 PDZ and LIM domain protein 5 isoform ENH3a No No Yes Actin Cytoskeleton
Pef1 peflin No Yes Yes Vesicle Transport
Pin1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1  Yes No No Regulation of Transcription
Pkd2 polycystin-2 No Yes No Vesicle Transport
Plin3 perilipin-3 No No Yes Vesicle Transport
Plscr1 phospholipid scramblase 1 No No Yes Regulation of Transcription
Pola2 DNA polymerase alpha subunit B  No Yes Yes Metabolic Enzyme
Ppp1r2 protein phosphatase inhibitor 2 No No Yes Protein Phosphatase Regulation
Ppp2ca serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Yes No No S/T Protein Phosphatase
Ppp2r1b serine/threonine-protein phosphatase 2A regulatory subunit A beta isoform  Yes No No Protein Phosphatase Regulation
Ppp6r3 serine/threonine-protein phosphatase 6 regulatory subunit 3  No Yes No Protein Phosphatase Regulation
Prdx3 thioredoxin-dependent peroxide reductase, mitochondrial  Yes No No Metabolic Enzyme
Prdx4 peroxiredoxin-4   Yes No No Metabolic Enzyme
Prkab2 5'-AMP-activated protein kinase subunit beta-2 No Yes No Protein Kinase Regulation 
Prkar1a cAMP-dependent protein kinase type I-alpha regulatory subunit No Yes Yes Protein Kinase Regulation 
Prmt5 protein arginine N-methyltransferase 5  Yes No No Regulation of Transcription
Prnp major prion protein  No Yes No Protein Folding
Prom1 prominin-1 isoform s8  Yes Yes No Cholesterol Binding
Pskh1 serine/threonine-protein kinase H1 No No Yes Protein Kinase
Psmb5 proteasome subunit beta type-5 Yes No No Protein Degradation
Psmc1 26S proteasome regulatory subunit 4 Yes No No Protein Degradation
Psmd5 26S proteasome non-ATPase regulatory subunit 5  Yes No No Protein Degradation
Psrc1 proline/serine-rich coiled-coil protein 1 No No Yes Microtubule Cytoskeleton
Ptges3 prostaglandin E synthase 3 Yes Yes No Metabolic Enzyme
Ptgr2 prostaglandin reductase 2  No No Yes Mitochondrial Protein
Ptgs2 prostaglandin G/H synthase 2  No Yes No Metabolic Enzyme
Ptpn13 tyrosine-protein phosphatase non-receptor type 13 Yes No No Protein Phosphatase Regulation
Qdpr dihydropteridine reductase No No Yes Metabolic Enzyme
Rab10 ras-related protein Rab-10 Yes No No Vesicle Transport
Rab11b ras-related protein Rab-11B Yes No No Vesicle Transport
Rab23 ras-related protein Rab-23 Yes No No Vesicle Transport
Rab28 ras-related protein Rab-28  No No Yes Vesicle Transport
Rab7a ras-related protein Rab-7a No Yes No Vesicle Transport
Rab8a ras-related protein Rab-8A Yes No No Vesicle Transport
Rabl6 rab-like protein 6 Yes No No Vesicle Transport
Rad23a UV excision repair protein RAD23 homolog A  No No Yes Regulation of Transcription
Rad23b UV excision repair protein RAD23 homolog B No No Yes Regulation of Transcription
Ran GTP-binding nuclear protein Ran Yes No No GTPase activity
Ranbp1 ran-specific GTPase-activating protein Yes No No Small GTPase Binding
Rangap1 ran GTPase-activating protein 1  Yes Yes No Small GTPase Binding
Rbm3 RNA-binding protein 3  No No Yes RNA Bindiing
Ripk1 receptor-interacting serine/threonine-protein kinase 1 No No Yes Protein Kinase
Rita1 RBPJ-interacting and tubulin-associated protein 1 No No Yes Microtubule Cytoskeleton
Rnf34 E3 ubiquitin-protein ligase RNF34 No No Yes Ubiquitination
RO60 60 kDa SS-A/Ro ribonucleoprotein No Yes No RNA Bindiing
Rpgr X-linked retinitis pigmentosa GTPase regulator  No No Yes Cilium Structure
Rpgrip1l protein fantom No No Yes Protein Degradation
Rpl12 60S ribosomal protein L12 Yes No No Translation
Rpl18 60S ribosomal protein L18 Yes No No Translation
Rpl21 60S ribosomal protein L21 Yes No No Translation
Rpl4 60S ribosomal protein L4 Yes No No Translation
Rpl7 60S ribosomal protein L7 Yes No No Translation
Rpl9 60S ribosomal protein L9 Yes No No Translation
Rplp2 60S acidic ribosomal protein P2  Yes No No Translation
Rps12 40S ribosomal protein S12 Yes No No Translation
Rps14 40S ribosomal protein S14 Yes No No Translation
Rpsa 40S ribosomal protein SA Yes No No Translation
Rrm1 ribonucleoside-diphosphate reductase large subunit No Yes No Metabolic Enzyme
Ruvbl2 ruvB-like 2 Yes No No Regulation of Transcription
Sars serine--tRNA ligase, cytoplasmic  Yes No No Translation
Sec23a protein transport protein Sec23A Yes Yes No Vesicle Transport
Sec23b protein transport protein Sec23B  Yes No No Vesicle Transport
Sec24b protein transport protein Sec24B Yes No No Vesicle Transport
Sept11 Septin-11 No Yes Yes Transition Zone of Primary Cilium
Sept2 Septin-2 Yes Yes No Transition Zone of Primary Cilium
Sept7 Septin-7 No Yes Yes Transition Zone of Primary Cilium
Sept9 Septin-9 Yes No Yes Transition Zone of Primary Cilium
Serbp1 plasminogen activator inhibitor 1 RNA-binding protein  Yes No No RNA Bindiing
Sh3gl1 endophilin-A2  No Yes No Vesicle Transport
Sh3glb1 endophilin-B1  No No Yes Vesicle Transport
Ska1 spindle and kinetochore-associated protein 1 No Yes No Microtubule Cytoskeleton
Ska2 spindle and kinetochore-associated protein 2 No Yes No Microtubule Cytoskeleton
Ska3 spindle and kinetochore-associated protein 3 No Yes Yes Microtubule Cytoskeleton
Slc2a1 solute carrier family 2, facilitated glucose transporter member 1 Yes No No Solute Carrier Protein
Slc39a10 zinc transporter ZIP10  No Yes No Solute Carrier Protein
Slc44a1 choline transporter-like protein 1  No Yes No Solute Carrier Protein
Slk STE20-like serine/threonine-protein kinase  No Yes No Protein Kinase
Smad2 mothers against decapentaplegic homolog 2  No Yes No Transcription Factor
Snap29 synaptosomal-associated protein 29 No No Yes Vesicle Transport
Sntb2 beta-2-syntrophin  Yes No No Vesicle Transport
Snx9 sorting nexin-9 No No Yes Vesicle Transport
Spg20 spartin  No No Yes Mitochondrial Protein
Sra1 steroid receptor RNA activator 1  No No Yes Microtubule Cytoskeleton
Sri sorcin  No Yes Yes Vesicle Transport
Stat3 signal transducer and activator of transcription 3  No Yes No Transcription Factor
Stip1 stress-induced-phosphoprotein 1 No Yes No Protein Folding
Stk10 serine/threonine-protein kinase 10  Yes No No Protein Kinase
Stk11 serine/threonine-protein kinase STK11 No No Yes Protein Kinase
Stradb STE20-related kinase adapter protein beta No Yes Yes Protein Kinase
Sufu suppressor of fused homolog  No Yes Yes Smoothened/Hedgehog Signaling 
Surf4 surfeit locus protein 4 Yes No No Golgi Structure
Syncrip heterogeneous nuclear ribonucleoprotein Q  Yes No No RNA Bindiing
Taf15 TATA-binding protein-associated factor 2N No No Yes Regulation of Transcription
Tagln2 transgelin-2 No Yes Yes Actin Cytoskeleton
Tars1 Threonine--tRNA ligase 1, cytoplasmic No Yes No Translation
Tbc1d32 protein broad-minded Yes No Yes Smoothened/Hedgehog Signaling 
Tchp trichoplein keratin filament-binding protein No No Yes Cilium Structure
Tctex1d2 tctex1 domain-containing protein 2 No No Yes Microtubule Cytoskeleton
Thop1 thimet oligopeptidase No Yes No Mitochondrial Protein
Tigar fructose-2,6-bisphosphatase TIGAR No Yes No Mitochondrial Protein
Tmem70 transmembrane protein 70, mitochondrial  No Yes No Mitochondrial Protein
Togaram1 TOG array regulator of axonemal microtubules protein 1  No Yes No Microtubule Cytoskeleton
Tom1 target of Myb protein 1  No Yes Yes Vesicle Transport
Tom1l2 TOM1-like protein 2  No Yes No Vesicle Transport
Tpd52 tumor protein D52  Yes No Yes ?
Tpi1 triosephosphate isomerase Yes No No Metabolic Enzyme
Tpm3 tropomyosin alpha-3 chain isoform Tpm3.12st No Yes No Actin Cytoskeleton
Tpt1 translationally-controlled tumor protein No No Yes Microtubule Cytoskeleton
Traf3ip1 TRAF3-interacting protein 1 Yes No Yes Cilium Structure
Tsg101 tumor susceptibility gene 101 protein  No No Yes Multivesicular body
Ttc21b tetratricopeptide repeat protein 21B  Yes Yes Yes Smoothened/Hedgehog Signaling 
Ttc23 tetratricopeptide repeat protein 23  No No Yes Smoothened/Hedgehog Signaling 
Ttc26 intraflagellar transport protein 56 Yes Yes Yes Smoothened/Hedgehog Signaling 
Ttc30a1 tetratricopeptide repeat protein 30A1 No No Yes Cilium Structure
Ttc30b tetratricopeptide repeat protein 30B Yes No Yes Cilium Structure
Ttc8 tetratricopeptide repeat protein 8  No No Yes Cilium Structure
Tuba1a tubulin alpha-1A chain No Yes No Microtubule Cytoskeleton
Tuba1b tubulin alpha-1B chain Yes No No Microtubule Cytoskeleton
Tuba1c tubulin alpha-1C chain Yes No No Microtubule Cytoskeleton
Tuba4a tubulin alpha-4A chain  Yes No No Microtubule Cytoskeleton
Tubb2a tubulin beta-2A chain Yes No No Microtubule Cytoskeleton
Tubb2b tubulin beta-2B chain Yes No No Microtubule Cytoskeleton
Tubb2c tubulin, beta 2C Yes No No Microtubule Cytoskeleton
Tubb3 tubulin beta-3 chain Yes No No Microtubule Cytoskeleton
Tubb5 tubulin beta-5 chain Yes No No Microtubule Cytoskeleton
Tubb6 tubulin beta-6 chain Yes No No Microtubule Cytoskeleton
Txnl1 thioredoxin-like protein 1 No Yes No Protein Degradation
Uba1 ubiquitin-like modifier-activating enzyme 1  No Yes No Ubiquitination
Uba6 ubiquitin-like modifier-activating enzyme 6 No Yes No Ubiquitination
Ube4b ubiquitin conjugation factor E4 B Yes No No Ubiquitination
Ubr4 E3 ubiquitin-protein ligase UBR4 Yes No No Ubiquitination
Unc119b protein unc-119 homolog B No Yes No Cilium Structure
Usp14 ubiquitin carboxyl-terminal hydrolase 14  Yes No No Ubiquitination
Vcl vinculin No Yes No Actin Cytoskeleton
Vcp transitional endoplasmic reticulum ATPase No Yes No Ubiquitination
Vps37b vacuolar protein sorting-associated protein 37B No No Yes Multivesicular body
Vps37c vacuolar protein sorting-associated protein 37C  No No Yes Multivesicular body
Vwa5a von Willebrand factor A domain-containing protein 5A No Yes No ?
Wbp2 WW domain-binding protein 2  No Yes Yes Regulation of Transcription
Wdr11 WD repeat-containing protein 11 Yes No No Smoothened/Hedgehog Signaling 
Wdr19 WD repeat-containing protein 19  Yes No Yes GPCR Targeting to Cilium
Wdr34 WD repeat-containing protein 34 Yes No No Microtubule Cytoskeleton
Wdr35 WD repeat-containing protein 35  Yes Yes Yes GPCR Targeting to Cilium
Wdr60 WD repeat-containing protein 60  Yes No Yes Microtubule Cytoskeleton
Xpo5 exportin-5 Yes No No Nuclear Transport
Xpo7 exportin-7  Yes No No Nuclear Transport
Ythdf3 YTH domain-containing family protein 3  No Yes Yes RNA Bindiing
Ywhae 14-3-3 protein epsilon No No Yes Protein Binding
Ywhaz 14-3-3 protein zeta/delta  Yes Yes Yes Protein Binding
Zc2hc1a zinc finger C2HC domain-containing protein 1A No No Yes Zinc finger protein
Znf330 zinc finger protein 330 No No Yes Zinc finger protein

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Gene Symbol Annotation Ishikawa et al.  Mick et al.  May et al. Descriptor

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