National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


EGF Responsive Phosphorylation Sites in Native Rat IMCD Cells

Epidermal Growth Factor (EGF) Signaling Network: Undirected graph depicting the mapping of proteins containing altered phosphorylation sites to specific cellular functions or structures (gray nodes). The red and blue nodes indicate specific phosphorylation sites altered in response to 1 microM EGF (red, increased, blue, decreased). Network was constructed from the full phosphoproteomic data set using Gene Ontology terms and Pubmed entries. Cytoscape was used for visualization.

Database was created by Nipun Jayatissa, Joe Chou and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

For questions and concerns please contact: knepperm@nhlbi.nih.gov.

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Phosphoproteomic Network