Below are the lysine acetyltransferases found in mammals and where they are expressed along the rat nephron. Lysine acetyltransferases must bind acetyl-Coenzyme A and have a catalytic domain. BLAST searches with conserved catalytic domains were completed to identify putative novel lysine acetyltransferases. Proteins that may have acetyltransferase activity, but lack experimental evidence for intrinsic activity are listed as putative lysine acetyltransferases.
This database provides median RPKM values for the transcriptome of 14 separate renal tubule segments in untreated male Sprague-Dawley rats (200-250 g BW). The number of replicates is shown in parentheses. The rat RNA-Seq analysis of microdissected rat kidney tubule segments was published by: Lee JW, Chou CL, and Knepper MA. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol 2015 Mar 27. pii: ASN.2014111067 PMID: 25817355
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To see expression of all transcripts along the rat nephron click here .
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Reference: paper under review
This website was created by Kelly Hyndman and Mark Knepper. Contact us with questions or comments: knep@helix.nih.gov or hyndmank@uab.edu.
| UniProt | Protein Name | Gene | S1 | S2 | S3 | SDL | LDLOM | LDLIM | tAL | mTAL | cTAL | DCT | CNT | CCD | OMCD | IMCD |
| Symbol | (7) | (7) | (7) | (10) | (9) | (4) | (7) | (7) | (7) | (9) | (6) | (11) | (7) | (8) | ||
| Q9WTK2 | chromodomain Y-like protein | Cdyl | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 1.3 | 0.0 | 3.8 |
| O08785 | circadian locomoter output cycles protein kaput | Clock | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| P45481 | CREB-binding protein | Crebbp | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 | 7.0 | 2.4 | 0.0 | 1.3 | 2.6 | 0.9 | 2.9 | 0.6 | 0.2 |
| Q8BMQ2 | general transcription factor 3C polypeptide 4 | Gtf3c4 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 4.3 | 0.2 | 0.0 | 0.0 | 0.0 | 0.6 | 0.5 | 0.0 | 0.0 |
| Q8BY71 | histone acetyltransferase type B catalytic subunit | Hat1 | 0.3 | 1.0 | 0.2 | 3.2 | 0.2 | 8.0 | 0.9 | 1.8 | 8.0 | 5.2 | 6.3 | 34.1 | 0.0 | 3.0 |
| Q9JHD2 | histone acetyltransferase KAT2A | Kat2a | 0.1 | 0.2 | 0.0 | 0.0 | 0.0 | 8.2 | 0.3 | 0.0 | 2.0 | 1.3 | 1.5 | 1.4 | 0.0 | 10.0 |
| Q8CHK4 | histone acetyltransferase KAT5 | Kat5 | 5.7 | 11.4 | 0.2 | 5.7 | 0.1 | 40.5 | 9.8 | 1.4 | 10.6 | 22.8 | 7.0 | 23.9 | 0.2 | 13.7 |
| Q8BZ21 | histone acetyltransferase KAT6A | Kat6a | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 1.8 | 1.9 | 0.0 | 0.7 | 0.0 | 0.1 | 0.1 | 0.0 | 0.6 |
| Q5SVQ0 | histone acetyltransferase KAT7 | Kat7 | 0.1 | 7.0 | 1.0 | 27.6 | 29.2 | 15.4 | 8.8 | 0.1 | 8.1 | 5.2 | 9.6 | 16.0 | 0.8 | 31.8 |
| Q9D1P2 | histone acetyltransferase KAT8 | Kat8 | 14.3 | 69.1 | 71.0 | 42.6 | 21.7 | 32.5 | 23.1 | 12.4 | 19.9 | 19.8 | 11.9 | 25.1 | 7.2 | 46.3 |
| P70365 | nuclear receptor coactivator 1 | Ncoa1 | 1.6 | 0.5 | 0.0 | 3.3 | 4.3 | 7.8 | 5.3 | 0.1 | 3.5 | 6.0 | 3.3 | 10.4 | 4.0 | 2.9 |
| Q80UV9 | transcription initiation factor TFIID subunit 1 | Taf1 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 6.4 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.0 | 1.8 |
| Q8QZT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acat1 | 70.2 | 58.2 | 60.5 | 38.6 | 88.3 | 25.6 | 60.4 | 164.3 | 77.4 | 114.0 | 53.1 | 129.8 | 95.6 | 29.8 |
| Q8K341 | alpha-tubulin N-acetyltransferase 1 | Atat1 | 4.8 | 2.5 | 8.5 | 6.7 | 11.2 | 6.9 | 11.1 | 5.7 | 12.9 | 24.9 | 10.4 | 26.1 | 2.1 | 11.2 |
| Q8K224 | RNA cytidine acetyltransferase | Nat10 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.8 | 0.4 | 0.3 | 0.3 | 0.0 | 0.4 |
| Putative lysine acetylatransferases | ||||||||||||||||
| Q9DBU2 | N-alpha-acetyltransferase 60 isoform 1 | Naa60 | 9.0 | 18.6 | 6.8 | 1.0 | 0.1 | 22.9 | 12.8 | 0.7 | 12.8 | 28.5 | 30.1 | 27.8 | 9.3 | 20.1 |
| Q9EQQ9 | Protein O-GlcNAcase | Mgea5 | 4.7 | 2.7 | 0.0 | 0.3 | 8.7 | 25.0 | 29.7 | 0.3 | 1.3 | 5.1 | 12.7 | 9.5 | 6.2 | 15.5 |
| E9QA25 | cat eye syndrome critical region protein 2 | Cecr2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 |
| O55102 | Biogenesis of lysosome-related organelles complex 1 subunit 1 | Bloc1s1 | 52.3 | 28.6 | 116.5 | 8.6 | 15.5 | 8.5 | 15.7 | 45.2 | 70.9 | 59.6 | 43.5 | 55.7 | 82.7 | 18.8 |
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