National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


De-ubiquitination Enzymes (DUBs)

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules.

Database was created by Zhe Xue, Yue Zhao, and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

The database includes 122 genes. Click to download processed data as spreadsheet.

To search, use browser's Find command (Ctrl-F)

Gene Symbol Protein Name Subcellular Location   Specificity Calculated MW Species UniProtKB
ATXN3 ataxin-3 isoform 2  Nucleus matrix  Ubiquitin 3179 Homo sapiens P54252
ATXN3L putative ataxin-3-like protein  Nucleus  Ubiquitin 40616 Homo sapiens Q9H3M9
BAP1 ubiquitin carboxyl-terminal hydrolase BAP1  Nucleus, Cytoplasm  Ubiquitin 80231 Homo sapiens Q92560
BRCC3 lys-63-specific deubiquitinase BRCC36  Nucleus, Cytoplasm, Cytoskeleton, Spindle pole  Ubiquitin 33106 Homo sapiens P46736
COPS5 COP9 signalosome complex subunit 5 isoform 2  Cytoplasm, Nucleus, Perinuclear region, Cytoplasmic vesicle, Secretory vesicle Nedd8 37448 Homo sapiens Q92905
COPS6 COP9 signalosome complex subunit 6  Nucleus, Cytoplasm Nedd8 36032 Homo sapiens Q7L5N1
CYLD ubiquitin carboxyl-terminal hydrolase CYLD isoform c  Cytoplasm,Perinuclear region, Cytoskeleton, Peripheral membrane protein,  Centrosome Ubiquitin 106914 Homo sapiens Q9NQC7
DESI1 desumoylating isopeptidase 1 isoform X1 Cytoplasm, Nucleus SUMO 22877 Homo sapiens Q6ICB0
DESI2 desumoylating isopeptidase 2 isoform X4 Cytoplasm SUMO 16926 Homo sapiens Q9BSY9
EIF3F eukaryotic translation initiation factor 3 subunit F  Cytoplasm  Ubiquitin 37433 Homo sapiens O00303
EIF3H eukaryotic translation initiation factor 3 subunit H  Cytoplasm  Ubiquitin 39799 Homo sapiens O15372
JOSD1 josephin-1  Cell membrane, Cytoplasm   Ubiquitin 23067 Homo sapiens Q15040
JOSD2 josephin-2  Cytoplasm, Cytosol  Ubiquitin 15968 Homo sapiens Q8TAC2
MPND MPN domain-containing protein Nucleus (predicted) Ubiquitin 54029 Homo sapiens Q8N594
MYSM1 histone H2A deubiquitinase MYSM1  Nucleus  Ubiquitin 94902 Homo sapiens Q5VVJ2
OTUB1 ubiquitin thioesterase OTUB1  Cytoplasm  Ubiquitin 31153 Homo sapiens Q96FW1
OTUB2 ubiquitin thioesterase OTUB2 isoform 1 Nucleus Ubiquitin 27082 Homo sapiens Q96DC9
OTUD1 OTU domain-containing protein 1 Cytosol (predicted) Ubiquitin 50932 Homo sapiens Q5VV17
OTUD3 OTU domain-containing protein 3 Cytosol, Cytoskeleton, Nucleus (predicted) Ubiquitin 44993 Homo sapiens Q5T2D3
OTUD4 OTU domain-containing protein 4 isoform 1 Cytosol (predicted) Ubiquitin 116951 Homo sapiens Q01804
OTUD5 OTU domain-containing protein 5 isoform 3 Cytosol Ubiquitin 39054 Homo sapiens Q96G74
OTUD6A OTU domain-containing protein 6A ? Ubiquitin 33169 Homo sapiens Q7L8S5
OTUD6B OTU domain-containing protein 6B Cytosol, Golgi apparatus, Nucleus   (predicted) Ubiquitin 21678 Homo sapiens Q8N6M0
OTUD7A OTU domain-containing protein 7A  Cytoplasm, Nucleus  Ubiquitin 100546 Homo sapiens Q8TE49
OTUD7B OTU domain-containing protein 7B  Cytoplasm, Nucleus, Shuttles be Cytoplasm and the Nucleus Ubiquitin 92395 Homo sapiens Q6GQQ9
OTULIN ubiquitin thioesterase otulin  Cytoplasm  Ubiquitin 40132 Homo sapiens Q96BN8
PAN2 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform 3  Cytoplasm  Ubiquitin 135150 Homo sapiens Q504Q3
PARP11 poly [ADP-ribose] polymerase 11  Nucleus, nuclear pore complex  Ubiquitin 30081 Homo sapiens Q9NR21
PRPF8 pre-mRNA-processing-splicing factor 8  Nucleus speckle  Ubiquitin 273471 Homo sapiens Q6P2Q9
PSMD14 26S proteasome non-ATPase regulatory subunit 14 Cytosol, Nucleus, Extracellular exosome, Proteasome complex Ubiquitin 34446 Homo sapiens O00487
PSMD7 26S proteasome non-ATPase regulatory subunit 7 Cytosol, Nucleus, Extracellular exosome, Proteasome complex Ubiquitin 36894 Homo sapiens P51665
SENP1 sentrin-specific protease 1 isoform X10 Nucleus, Cytoplasm SUMO 49546 Homo sapiens Q9P0U3
SENP2 sentrin-specific protease 2 isoform X3 Nucleus, Cytoplasm SUMO 49793 Homo sapiens Q9HC62
SENP3 sentrin-specific protease 3 Nucleus, Nucleolus SUMO 64879 Homo sapiens Q9H4L4
SENP5 sentrin-specific protease 5 isoform X5 Nucleus, Nucleolus SUMO 81179 Homo sapiens Q96HI0
SENP6 sentrin-specific protease 6 isoform X7 Nucleus  SUMO 113298 Homo sapiens Q9GZR1
SENP7 sentrin-specific protease 7 isoform 6 Nucleus, Cytosol SUMO 19139 Homo sapiens Q9BQF6
SENP8 sentrin-specific protease 8 isoform X2 Nucleus Nedd8 23976 Homo sapiens Q96LD8
STAMBP STAM-binding protein  Nucleus, Membrane; Peripheral membrane protein, Cytoplasm, Early endosome Ubiquitin 47946 Homo sapiens O95630
STAMBPL1 AMSH-like protease Plasma membrane, Endosome (predicted) Ubiquitin 49652 Homo sapiens Q96FJ0
UCHL1 ubiquitin carboxyl-terminal hydrolase isozyme L1  Cytoplasm, Endoplasmic reticulum membrane, Lipid-anchor  Ubiquitin 24693 Homo sapiens P09936
UCHL3 ubiquitin carboxyl-terminal hydrolase isozyme L3  Cytoplasm Ubiquitin 21814 Homo sapiens P15374
Uchl4 ubiquitin carboxyl-terminal hydrolase isozyme L4  Cytoplasm  Ubiquitin 26319 Mus musculus P58321
UCHL5 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2  Cytoplasm, Nucleus   Ubiquitin 35948 Homo sapiens Q9Y5K5
USP1 ubiquitin carboxyl-terminal hydrolase 1  Nucleus  Ubiquitin 88076 Homo sapiens O94782
USP10 ubiquitin carboxyl-terminal hydrolase 10 isoform 2  Cytoplasm, Nucleus, Early endosome   Ubiquitin 87403 Homo sapiens Q14694
USP11 ubiquitin carboxyl-terminal hydrolase 11  Nucleus, Cytoplasm  Ubiquitin 109686 Homo sapiens P51784
USP12 ubiquitin carboxyl-terminal hydrolase 12 ? Ubiquitin 42727 Homo sapiens O75317
USP13 ubiquitin carboxyl-terminal hydrolase 13 lysosome, vacuole, Cytosol, Nucleus (predicted) Ubiquitin 97196 Homo sapiens Q92995
USP14 ubiquitin carboxyl-terminal hydrolase 14 isoform 2  Cytoplasm, Cell membrane, Peripheral membrane protein  Ubiquitin 52255 Homo sapiens P54578
USP15 ubiquitin carboxyl-terminal hydrolase 15 isoform 2  Cytoplasm, Nucleus  Ubiquitin 26963 Homo sapiens Q9Y4E8
USP16 ubiquitin carboxyl-terminal hydrolase 16  Nucleus Ubiquitin 93439 Homo sapiens Q9Y5T5
USP17L10 ubiquitin carboxyl-terminal hydrolase 17-like protein 10  Nucleus, Endoplasmic reticulum  Ubiquitin 59755 Homo sapiens C9JJH3
USP17L11 ubiquitin carboxyl-terminal hydrolase 17-like protein 11  Nucleus, Endoplasmic reticulum  Ubiquitin 59499 Homo sapiens C9JVI0
USP17L12 ubiquitin carboxyl-terminal hydrolase 17-like protein 12  Nucleus, Endoplasmic reticulum  Ubiquitin 59556 Homo sapiens C9JPN9
USP17L13 ubiquitin carboxyl-terminal hydrolase 17-like protein 13  Nucleus, Endoplasmic reticulum  Ubiquitin 59563 Homo sapiens C9JLJ4
USP17L15 ubiquitin carboxyl-terminal hydrolase 17-like protein 15  Nucleus, Endoplasmic reticulum  Ubiquitin 63256 Homo sapiens C9J2P7
USP17L17 ubiquitin carboxyl-terminal hydrolase 17-like protein 17  Nucleus, Endoplasmic reticulum  Ubiquitin 59496 Homo sapiens D6RBQ6
USP17L18 ubiquitin carboxyl-terminal hydrolase 17-like protein 18  Nucleus, Endoplasmic reticulum  Ubiquitin 59526 Homo sapiens D6R9N7
USP17L19 ubiquitin carboxyl-terminal hydrolase 17-like protein 19  Nucleus, Endoplasmic reticulum  Ubiquitin 59527 Homo sapiens D6RCP7
USP17L20 ubiquitin carboxyl-terminal hydrolase 17-like protein 20  Nucleus, Endoplasmic reticulum  Ubiquitin 59495 Homo sapiens D6RJB6
USP17L21 ubiquitin carboxyl-terminal hydrolase 17-like protein 21  Nucleus, Endoplasmic reticulum  Ubiquitin 59528 Homo sapiens D6R901
USP17L22 ubiquitin carboxyl-terminal hydrolase 17-like protein 22  Nucleus, Endoplasmic reticulum  Ubiquitin 59540 Homo sapiens D6RA61
USP17L3 ubiquitin carboxyl-terminal hydrolase 17-like protein 3  Nucleus, Endoplasmic reticulum  Ubiquitin 59405 Homo sapiens A6NCW0
USP17L4 inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4  Nucleus, Endoplasmic reticulum  Ubiquitin 59505 Homo sapiens A6NCW7
USP17L5 ubiquitin carboxyl-terminal hydrolase 17-like protein 5  Nucleus, Endoplasmic reticulum  Ubiquitin 59552 Homo sapiens A8MUK1
USP17L7 inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7  Nucleus, Endoplasmic reticulum  Ubiquitin 59620 Homo sapiens P0C7H9
USP17L8 inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8  Nucleus, Endoplasmic reticulum  Ubiquitin 59504 Homo sapiens P0C7I0
USP17La ubiquitin carboxyl-terminal hydrolase 17-like protein A ? Ubiquitin 58942 Mus musculus Q61068
Usp17lb deubiquitinating enzyme 1a ? Ubiquitin 51983 Mus musculus  E9Q9U0
Usp17lc deubiquitinating enzyme 2 ? Ubiquitin 61353 Mus musculus G5E8I7
Usp17ld deubiquitinating enzyme 2a ? Ubiquitin 61320 Mus musculus Q923V2
USP17Le ubiquitin carboxyl-terminal hydrolase 17-like protein E  Nucleus, Endoplasmic reticulum  Ubiquitin 59997 Mus musculus Q7M764
USP18 ubl carboxyl-terminal hydrolase 18 Cytoplasm, Nucleus  Ubiquitin 42880 Homo sapiens Q9UMW8
USP19 ubiquitin carboxyl-terminal hydrolase 19 isoform 5  Endoplasmic reticulum membrane, Single-pass membrane protein  Ubiquitin 150528 Homo sapiens O94966
USP2 ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69  Cytoplasm, Perinuclear region, Nucleus   Ubiquitin 41551 Homo sapiens O75604
USP20 ubiquitin carboxyl-terminal hydrolase 20  Cytoplasm, Perinuclear region, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome  Ubiquitin 101872 Homo sapiens Q9Y2K6
USP21 ubiquitin carboxyl-terminal hydrolase 21  Cytoplasm, Nucleus   Ubiquitin 60991 Homo sapiens Q9UK80
USP22 ubiquitin carboxyl-terminal hydrolase 22  Nucleus Ubiquitin 59830 Homo sapiens Q9UPT9
USP24 ubiquitin carboxyl-terminal hydrolase 24 Cytoplasm Ubiquitin 294236 Homo sapiens Q9UPU5
USP25 ubiquitin carboxyl-terminal hydrolase 25  Cytoplasm, Nucleus  Ubiquitin 129832 Homo sapiens Q9UHP3
USP26 ubiquitin carboxyl-terminal hydrolase 26  Nucleus  Ubiquitin 103916 Homo sapiens Q9BXU7
USP27X ubiquitin carboxyl-terminal hydrolase 27 ? Ubiquitin 49500 Homo sapiens A6NNY8
USP28 ubiquitin carboxyl-terminal hydrolase 28  Nucleus, Nucleoplasm  Ubiquitin 122361 Homo sapiens Q96RU2
USP29 ubiquitin carboxyl-terminal hydrolase 29 Nucleus (predicted) Ubiquitin 104025 Homo sapiens Q9HBJ7
USP3 ubiquitin carboxyl-terminal hydrolase 3 isoform 2  Nucleus  Ubiquitin 53612 Homo sapiens Q9Y6I4
USP30 ubiquitin carboxyl-terminal hydrolase 30  Mitochondrion outer membrane  Ubiquitin 58372 Homo sapiens Q70CQ3
USP31 ubiquitin carboxyl-terminal hydrolase 31 Nucleus, Cytosol Ubiquitin 146521 Homo sapiens Q70CQ4
USP32 ubiquitin carboxyl-terminal hydrolase 32  Membrane; Lipid-anchor, Golgi apparatus  Ubiquitin 181525 Homo sapiens Q8NFA0
USP33 ubiquitin carboxyl-terminal hydrolase 33 isoform 2  Cytoplasm, Perinuclear region, Cytoskeleton, Microtubule
            organizing center, Centrosome 		 Ubiquitin 103152 Homo sapiens Q8TEY7
USP34 ubiquitin carboxyl-terminal hydrolase 34 Cytosol, Nucleus, Plasma membrane, Cytoskeleton, Extracellular Ubiquitin 404104 Homo sapiens Q70CQ2
USP35 ubiquitin carboxyl-terminal hydrolase 35 Nucleus (predicted) Ubiquitin 113274 Homo sapiens Q9P2H5
USP36 ubiquitin carboxyl-terminal hydrolase 36  Nucleus, Nucleolus  Ubiquitin 122777 Homo sapiens Q9P275
USP37 ubiquitin carboxyl-terminal hydrolase 37 isoform 2 Nucleus, Cytoskeleton Ubiquitin 110013 Homo sapiens Q86T82
USP38 ubiquitin carboxyl-terminal hydrolase 38 Cytosol, Nucleus, Golgi apparatus (predicted)  Ubiquitin 113026 Homo sapiens Q8NB14
USP39 U4/U6.U5 tri-snRNP-associated protein 2  Nucleus  Ubiquitin 53379 Homo sapiens Q53GS9
USP4 ubiquitin carboxyl-terminal hydrolase 4 isoform 2  Cytoplasm, Nucleus  Ubiquitin 35530 Homo sapiens Q13107
USP40 ubiquitin carboxyl-terminal hydrolase 40 isoform 1 Cytoplasm, Nucleus, Cytosol, Peroxisome,
Endoplasmic reticulum, Extracellular, Plasma membrane		 Ubiquitin 141428 Homo sapiens Q9NVE5
USP41 PREDICTED: putative ubiquitin carboxyl-terminal hydrolase 41 isoform X1 Nucleus (predicted) Ubiquitin 42740 Homo sapiens Q3LFD5
USP42 ubiquitin carboxyl-terminal hydrolase 42 Nucleus (predicted) Ubiquitin 144204 Homo sapiens Q9H9J4
USP43 ubiquitin carboxyl-terminal hydrolase 43 isoform 2 Nucleus (predicted) Ubiquitin 122163 Homo sapiens Q70EL4
USP44 ubiquitin carboxyl-terminal hydrolase 44 isoform 1  Nucleus  Ubiquitin 81054 Homo sapiens Q9H0E7
USP45 ubiquitin carboxyl-terminal hydrolase 45 isoform 2 Cytoplasm, Nucleus, Cytosol,
Extracellular		 Ubiquitin 91603 Homo sapiens Q70EL2
USP46 ubiquitin carboxyl-terminal hydrolase 46 Lysosome, Vacuole (predicted) Ubiquitin 40981 Homo sapiens P62068
USP47 ubiquitin carboxyl-terminal hydrolase 47 isoform 1  Cytoplasm  Ubiquitin 154567 Homo sapiens Q96K76
USP48 ubiquitin carboxyl-terminal hydrolase 48  Cytoplasm, Nucleus Ubiquitin 118902 Homo sapiens Q86UV5
USP49 ubiquitin carboxyl-terminal hydrolase 49  Nucleus Ubiquitin 79067 Homo sapiens Q70CQ1
USP5 ubiquitin carboxyl-terminal hydrolase 5 isoform 2 Lysosome, Vacuole, Cytosol (predicted) Ubiquitin 95656 Homo sapiens P45974
USP50 putative ubiquitin carboxyl-terminal hydrolase 50 Nucleus (predicted) Ubiquitin 38252 Homo sapiens Q70EL3
USP51 ubiquitin carboxyl-terminal hydrolase 51 Nucleus (predicted) Ubiquitin 79625 Homo sapiens Q70EK9
USP53 inactive ubiquitin carboxyl-terminal hydrolase 53 Golgi apparatus, Nucleus (predicted) Ubiquitin 120676 Homo sapiens Q70EK8
USP54 inactive ubiquitin carboxyl-terminal hydrolase 54 Mitochondrion (predicted) Ubiquitin 180367 Homo sapiens Q70EL1
USP6NL USP6 N-terminal-like protein isoform b  Golgi apparatus, Cytoplasmic vesicle Ubiquitin 95866 Homo sapiens Q92738
USP7 ubiquitin carboxyl-terminal hydrolase 7  Nucleus, Cytoplasm, PML body  Ubiquitin 121744 Homo sapiens Q93009
USP8 ubiquitin carboxyl-terminal hydrolase 8 isoform 1  Cytoplasm, Nucleus, Endosome membrane, Cell membrane, Peripheral membrane protein  Ubiquitin 127393 Homo sapiens P40818
USP9X probable ubiquitin carboxyl-terminal hydrolase FAF-X  Cytoplasm, Cytosol, Plasma membrane, Endosome, Lysosome, Vacuole  Ubiquitin 290333 Homo sapiens Q93008
USP9Y ubiquitin specific peptidase 9, Y chromosome  Cytoplasm  Ubiquitin 290947 Homo sapiens O00507
USPL1 SUMO-specific isopeptidase USPL1 isoform E  Nucleus, Cajal body  Ubiquitin 83963 Homo sapiens Q5W0Q7
USPL1 SUMO-specific isopeptidase USPL1 isoform X5 Nucleus, Cajal Body SUMO 100392 Homo sapiens Q5W0Q7
VCPIP1 deubiquitinating protein VCIP135  Endoplasmic reticulum, Golgi apparatus, Golgi stack, Endoplasmic reticulum Ubiquitin 134190 Homo sapiens Q96JH7
YOD1 ubiquitin thioesterase OTU1 Endoplasmic reticulum unfolded protein response Ubiquitin 33848 Homo sapiens Q5VVQ6
ZRANB1 ubiquitin thioesterase Zranb1  Cytoplasm, Nucleus Ubiquitin 80836 Homo sapiens Q9UGI0

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  Gene Symbol Protein Name Subcellular Location Specificity Calculated MW Species UniProtKB  

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