National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Phosphoproteomic Data: Response to Vasopressin

mpkCCD Phosphoproteome: Response to Vasopressin (Datta et al., 2021)
Rat IMCD Phosphoproteome: Steady State Response to Vasopressin (Deshpande et al., 2019)
Consensus Vasopressin-Regulated Phosphorylation Sites in Collecting Duct
Vasopressin-Regulated Phosphorylation Sites Mapped to Cell-Level Actions of Vasopressin

Rat IMCD Phosphoproteome: Time Course of Response to Vasopressin (TMT) (Leo et al., 2022)
Rat IMCD Phosphoproteome: Time Course of Response to Vasopressin (iTRAQ) (Hoffert et al., 2012)

Rat Medullary Thick Ascending Limb Phosphoproteome: Response to PTH/AVP/Glucagon/Calcitonin (Gunaratne et al., 2010)


Phosphoproteomic Data: Effects of CRISPR Deletion of Specific Protein Kinases

Phosphoproteome: PKA Double Knockout in mpkCCD (Isobe et al., 2017)
Phosphoproteome: PKA Catalytic Alpha Knockout in mpkCCD (Raghuram et al., 2020)
Phosphoproteome: PKA Catalytic Beta Knockout in mpkCCD (Raghuram et al., 2020)
Phosphoproteome: Myosin Light Chain Kinase Knockout in mpkCCD (Isobe et al., 2020)



Direct Substrates of Specific Protein Kinases

Protein Kinase A Substrates



Legacy Phosphoproteomic Data

IMCD Phosphoproteome Database (Bansal et al., JASN, 2010)

Rat IMCD Non-Tryptic Phosphopeptides (Hyndman et al., Phsiol. Genomics, 2018)

Mouse mpkCCD Phosphoproteome Database (Rinschen et al., PNAS, 2010)

Collecting Duct Phosphoproteome Database (Hoffert et al., PNAS, 2006)

Inner Medullary Collecting Duct Phosphotyrosinome (Zhao et al., Am.J.Physiol., 2012)

IMCD Kinase Substrate Database (Bradford et al., Am.J.Physiol., 2014)

Renal Cortical Membrane Phosphoproteome Database (Feric et al., Am.J.Physiol., 2011)

Collaborative Phosphoproteomic Data

IMCD Phosphoproteome with Acute Lithium Treatment (Trepiccione et al., Kidney Int., 2014)

Mouse Glomerular Phosphoproteomic Database

Rat Glomerular Phosphoproteomic Database

Bovine Glomerular Phosphoproteomic Database

Cultured Mouse Podocyte Phosphoproteomic Database
mpkDCT Cell Phosphoproteome Database
Phosphoproteome Profiling of Response of HEK293 Cells to High NaCl


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Updated November 20, 2022 The Kidney Systems Biology Project website was created by members of the Epithealial Systems Biology Laboratory (Mark Knepper, Chief). Contact us with questions or comments: knep@helix.nih.gov
Database updated: March 28, 2016.


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