National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Phosphoproteomic Data: Response to Vasopressin

mpkCCD Phosphoproteome: Response to Vasopressin (Datta et al., 2021)
Rat IMCD Phosphoproteome: Steady State Response to Vasopressin (Deshpande et al., 2019)
Consensus Vasopressin-Regulated Phosphorylation Sites in Collecting Duct
Vasopressin-Regulated Phosphorylation Sites Mapped to Cell-Level Actions of Vasopressin

Rat IMCD Phosphoproteome: Time Course of Response to Vasopressin (TMT) (Leo et al., 2022)
Rat IMCD Phosphoproteome: Time Course of Response to Vasopressin (iTRAQ) (Hoffert et al., 2012)

Rat Medullary Thick Ascending Limb Phosphoproteome: Response to PTH/AVP/Glucagon/Calcitonin (Gunaratne et al., 2010)


Phosphoproteomic Data: Effects of CRISPR Deletion of Specific Protein Kinases

Phosphoproteome: PKA Double Knockout in mpkCCD (Isobe et al., 2017)
Phosphoproteome: PKA Catalytic Alpha Knockout in mpkCCD (Raghuram et al., 2020)
Phosphoproteome: PKA Catalytic Beta Knockout in mpkCCD (Raghuram et al., 2020)
Phosphoproteome: Myosin Light Chain Kinase Knockout in mpkCCD (Isobe et al., 2020)
Phosphoproteome: CAMK2-delta in mpkCCD (Park et al., 2023)


Phosphoproteomic Data: Response to Epidermal Growth Factor (EGF)

Epidermal Growth Factor Response in Rat Inner Medullary Collecting Duct
Epidermal Growth Factor (EGF) Signaling Network in Rat IMCD


Direct Substrates of Specific Protein Kinases

Protein Kinase A Substrates
Protein Kinase Substrate Preference Logos (Poll et al.)
Protein Kinase Substrate Preference Logos (Kinase Family Tree)

Legacy Phosphoproteomic Data

IMCD Phosphoproteome Database (Bansal et al., JASN, 2010)

Rat IMCD Non-Tryptic Phosphopeptides (Hyndman et al., Phsiol. Genomics, 2018)

Mouse mpkCCD Phosphoproteome Database (Rinschen et al., PNAS, 2010)

Collecting Duct Phosphoproteome Database (Hoffert et al., PNAS, 2006)

Inner Medullary Collecting Duct Phosphotyrosinome (Zhao et al., Am.J.Physiol., 2012)

IMCD Kinase Substrate Database (Bradford et al., Am.J.Physiol., 2014)

Renal Cortical Membrane Phosphoproteome Database (Feric et al., Am.J.Physiol., 2011)

Collaborative Phosphoproteomic Data

IMCD Phosphoproteome with Acute Lithium Treatment (Trepiccione et al., Kidney Int., 2014)

Mouse Glomerular Phosphoproteomic Database

Rat Glomerular Phosphoproteomic Database

Bovine Glomerular Phosphoproteomic Database



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Updated February 23, 2026. The Kidney Systems Biology Project website was created by members of the Epithealial Systems Biology Laboratory (Mark Knepper, Chief). Contact us with questions or comments: knep@helix.nih.gov


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