Kinase data obtained from Sugiyama et al. (PMID: 31324866) Hover over the Sugiyama ID for each kinase to show the amino acid preferences flanking the post-translational modified site as identified by PTMLogo . All logos were generated from a minimum of 30 amino acid sequences, using Chi-squared filtering alpha = 0.0001. Exact number of reference sequences used for each kinase shown below. PTMLogo published by Saethang et al. 2019, PMID: 31318409. This database was created by Brian Poll, Kirby Leo, and Mark A. Knepper in the Epithelial Systems Biology Laboratory at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project. Please contact Mark Knepper with any comments or questions.

The database includes 384 protein kinases. Click to download a complete pdf of all kinase motifs.

Supplemental Spreadsheet 1: Phosphoproteomic data curated from Sugiyama et al. 2019. Kinase sequence data used to create these sequence motifs was curated from the original publication (PMID: 31324866).

Methods: Protein kinases were incubated in vitro with dephosphorylated protein mixtures followed by protein mass spectrometry to identify phosphorylation events as described in Sugiyama et al. (PMID: 31324866). See the original paper for details.

Brackets indicate kinase mutated at the residues indicated. Slashes indicate combined kinase subunits. Amino acids are color coded based on their properties. L, I, M, V, A - green. K, R, H - blue, Q, N - purple, D, E - red, F, W, Y, P - dark grey, S, T - light grey, C - pink, G - orange. B represents the N-terminus and J represents the C-terminus.

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To view kinase sequence motif, hover cursor over kinase Sugiyama ID.

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