National Heart, Lung, and Blood Institute Epithelial Systems Biology Laboratory

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Basophil B-lymphocyte Collecting Duct Connecting Tubule Dendritic Cell Distal Convoluted Tubule Endothelial Cell Eosinophil Erythrocyte Fibroblast Granular Cell of Afferent Arteriole Interstitial Cell Loop of Henle Macrophage Macula Densa Mast Cell Megakaryocyte Mesangial Cell Monocyte Neuronal Cell Pericyte Plasma Cell Podocyte Polymorphonuclear Leukocyte Proximal Tubule Smooth Muscle Cell T-lymphocyte Transitional Epithelium

Cell Type Selective Markers: RNA-seq Analysis of Mouse Whole Kidney

This database provides mean TPM values for the cell type selective markers expressed in mouse whole kidney (WK) samples. The number of replicates is n=3. Make note that certain genes are listed as markers for multiple cell types. The markers were selected from the literature and sources are listed in the supplementary data for the publication. Reference: Clark JZ, Chen L, Chou CL, Jung HJ, Lee JW, Knepper MA. Representation and relative abundance of cell-type selective markers in whole-kidney RNA-Seq data. Kidney Int. 2019; 95:787-796 PMID: 30826016.

Brief Method: cDNA libraries were constructed for paired-end sequencing and sequenced on Illumina HiSeq3000 platform. Reads were mapped to mouse Ensembl Genome by STAR and transcript abundances were calculated in the units of transcripts per million (TPM) using RSEM (https://github.com/deweylab/RSEM).

Key: Gene symbols marked with an α superscript are listed as markers in multiple cell types. WK TPM values with a β superscript signify non-proximal tubule cell type selective markers with rat proximal tubule RPKM values >10 in at least one proximal tubule subsegment.

This website was created by Jevin Z. Clark, Lihe Chen, and Mark Knepper. Contact us with questions or comments: knep@helix.nih.gov. To search, use browser's search modality, usually Control-F.

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Basophil Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Basophil Ccr3α chemokine (C-C motif) receptor 3 0.00 >17742
Basophil Cd33 Cd33 Antigen 0.59 14450
Basophil Cd44α Cd44 Antigen 0.44 15176
Basophil Cd69 Cd69 Antigen 0.22 16835
Basophil Il3ra interleukin 3 receptor, alpha chain 0.45 15117

B-lymphocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
B-lymphocyte Cd79a B-cell antigen receptor complex-associated protein alpha1 0.3 15995
B-lymphocyte Cd79b B-cell antigen receptor complex-associated protein beta1 1.1 13149
B-lymphocyte Cd19 B-cell differentiation antigen1 0.1 >17742
B-lymphocyte (follicular) Cd22 B-cell receptor 0.2 17615
B-lymphocyte (follicular) Cd38α ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 8.5 8095
B-lymphocyte (follicular) Fcer2a Low affinity immunoglobulin epsilon Fc receptor 0.0 >17742
B-lymphocyte (follicular) Pax5α B-cell-specific transcription factor 0.0 >17742
B-lymphocyte (follicular) Ptprcα receptor-type tyrosine-protein phosphatase C 3.3 10651
B-lymphocyte (memory) Cd38α ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 8.5 8095
B-lymphocyte (memory) Cd80 Activation B7-1 antigen 0.0 >17742
B-lymphocyte (memory) Cd84 SLAM family member 5 0.5 14789
B-lymphocyte (memory) Cd86 Activation B7-2 antigen 2.0 11865
B-lymphocyte (memory) Nt5eα 5'-nucleotidase 101.2 1588
B-lymphocyte (memory) Pax5α B-cell-specific transcription factor 0.0 >17742
B-lymphocyte (memory) Ptprcα receptor-type tyrosine-protein phosphatase C 3.3 10651
B-lymphocyte (memory) Spib Transcription factor SPI-B 0.1 >17742

Collecting Duct Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Collecting Duct Principal Cells Acer2 alkaline ceramidase 2 9.4 7791
Collecting Duct Principal Cells Aqp2 aquaporin 2 464.1 317
Collecting Duct Principal Cells Aqp3 aquaporin 3 139.8 1170
Collecting Duct Principal Cells Aqp4 aquaporin 4 13.2 6776
Collecting Duct Principal Cells Avpr2 arginine vasopressin receptor 2 29.3 4300
Collecting Duct Principal Cells Fxyd4 FXYD domain-containing ion transport regulator 4  158.8 1004
Collecting Duct Principal Cells Fzd1 frizzled class receptor 1 17.8 5845
Collecting Duct Principal Cells Gata3α GATA binding protein 3 6.3 8952
Collecting Duct Principal Cells Lgals3α lectin, galactose binding, soluble 3 78.6β 1998
Collecting Duct Principal Cells Ptges prostaglandin E synthase 26.3 4633
Collecting Duct Principal Cells Stc1 stanniocalcin 1 3.3 10674
Collecting Duct Principal Cells Tmem45b transmembrane protein 45b 46.5 3083
Collecting Duct Principal Cells Tspan1 tetraspanin 1 55.5 2683
Intercalated A Cells Aqp6 aquaporin 6 3.9 10211
Intercalated A Cells Dmrt2 doublesex and mab-3 related transcription factor 2 2.3 11516
Intercalated A Cells P2ry14 purinergic receptor P2Y, G-protein coupled, 14 2.6 11240
Intercalated A Cells Slc4a1 solute carrier family 4 (anion exchanger), member 1 17.4 5905
Intercalated B Cells Ap1s3 adaptor-related protein complex AP-1, sigma 3 0.2 16678
Intercalated B Cells Insrr insulin receptor-related receptor  7.6 8407
Intercalated B Cells Slc26a4 solute carrier family 26, member 4 39.6 3484
Inner Medullary Collecting Duct S100a4α S100 calcium binding protein A4 6.5β 8850
Inner Medullary Collecting Duct Akr1b8 aldo-keto reductase family 1, member B8 3.3 10655
Inner Medullary Collecting Duct Gpha2 glycoprotein hormone alpha 2 0.1 >17742
Inner Medullary Collecting Duct Plekhb1 pleckstrin homology domain containing, family B(evectins) member 1   22.0 5196
Inner Medullary Collecting Duct Ccl2 chemokine (C-C motif) ligand 2  2.5 11329
Inner Medullary Collecting Duct Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 6.2 8972
Inner Medullary Collecting Duct Ccl7 chemokine (C-C motif) ligand 7 0.4 15433
Inner Medullary Collecting Duct Slfn2 schlafen 2   7.4 8458
Inner Medullary Collecting Duct Tm6sf1 transmembrane 6 superfamily member 1 7.1 8596
Inner Medullary Collecting Duct Fam20a family with sequence similarity 20, member A 1.8 12121
Inner Medullary Collecting Duct Slc14a2α solute carrier family 14 (urea transporter), member 2, long isoform 20.1 5484
Inner Medullary Collecting Duct Elf5 E74-like factor 5   0.7 14119

Connecting Tubule Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Connecting Tubule Calb1 calbindin 1 316.1 499
Connecting Tubule Ccl20 chemokine (C-C motif) ligand 20 0.0 >17742
Connecting Tubule Defb9 defensin beta 9  0.0 >17742
Connecting Tubule Fam89a family with sequence similarity 89, member A 0.9 13655
Connecting Tubule Stap1 signal transducing adaptor family member 1 2.8 11120
Connecting Tubule Trpv5 transient receptor potential cation channel, subfamily V, member 5 8.2 8184

Dendritic Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Dendritic cells Adgre1α adhesion G protein-coupled receptor E1 2.7 11123
Dendritic cells Ccl17 chemokine (C-C motif) ligand 17 0.7 14222
Dendritic cells Cd14α CD14 antigen 5.3 9436
Dendritic cells Cd207 langerin 0.1 >17742
Dendritic cells Cd209a Dendritic cell-specific ICAM-3-grabbing non-integrin 3.7 10391
Dendritic cells Cd8aα CD8 antigen, alpha chain 1.3 12713
Dendritic cells Cx3cr1α chemokine (C-X3-C motif) receptor 1 1.2 12968
Dendritic cells H2-Ab1α histocompatibility 2, class II antigen A, beta 1 210.7 772
Dendritic cells H2-Eb1α histocompatibility 2, class II antigen E beta 94.1 1706
Dendritic cells Itgae Integrin alpha E, epithelia-associated 0.6 14563
Dendritic cells Itgamα integrin alpha-M 0.8 13826
Dendritic cells Itgaxα integrin alpha-X precursor 0.7 14216
Dendritic cells Ly75 lymphocyte antigen 75 precursor 0.5 14761
Dendritic cells Pdcd1lg2 Programmed cell death 1 ligand 2 0.0 >17742
Dendritic cells Ptprcα receptor-type tyrosine-protein phosphatase C 3.3 10651
Dendritic cells Sirpa signal-regulatory protein alpha 31.4 4119

Distal Convoluted Tubule Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Distal convoluted tubule Cdc42ep3 CDC42 effector protein (Rho GTPase binding) 3 9.7 7708
Distal convoluted tubule Clec4a3 C-type lectin domain family 4, member a3 2.7 11162
Distal convoluted tubule Fetub fetuin beta 1.3 12833
Distal convoluted tubule Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 1.6 12290
Distal convoluted tubule Kcng1 potassium voltage-gated channel, subfamily G, member 1 2.4 11450
Distal convoluted tubule Mlana melan-A 0.0 >17742
Distal convoluted tubule Pcolce procollagen C-endopeptidase enhancer protein 77.7 2024
Distal convoluted tubule Plekho1 pleckstrin homology domain containing, family O member1 5.2 9479
Distal convoluted tubule Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.2 16618
Distal convoluted tubule Slc12a3 solute carrier family 12, member 3 179.1 892

Endothelial Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Endothelial Cell Adgrl4 adhesion G protein-coupled receptor L4 23.8 4948
Endothelial Cell Emcn endomucin  86.2β 1835
Endothelial Cell Eng endoglin  19.3 5601
Endothelial Cell Pecam1α platelet/endothelial cell adhesion molecule 1 16.8 6021
Endothelial Cell Plac8 placenta-specific 8 19.9 5510
Endothelial Cell Plvapα plasmalemma vesicle associated protein 134.5β 1216
Endothelial Cell Tekα endothelial-specific receptor tyrosine kinase 19.3 5600
Endothelial Cell Tspan8 tetraspanin 8  49.2 2946
Endothelial Cell Kdr kinase insert domain protein receptor 18.4 5736
Endothelial Cell Ets1 E26 avian leukemia oncogene 1, 5' domain 7.5 8453
Endothelial Cell (Fenestrated) Plvapα plasmalemma vesicle associated protein 134.5β 1216
Endothelial Cell (Fenestrated) Pecam1α platelet/endothelial cell adhesion molecule 1 16.8 6021
Endothelial Cell (Fenestrated) Cd34α CD34 antigen  20.3 5458
Endothelial Cell (Lymphatic) Cd34α CD34 antigen  20.3 5458
Endothelial Cell (Lymphatic) Pdpn podoplanin  2.1 11734
Endothelial Cell (Lymphatic) Pecam1α platelet/endothelial cell adhesion molecule 1 16.8 6021
Endothelial Cell (Lymphatic) Prox1 prospero homeobox 1 2.0 11888
Endothelial Cell (Lymphatic) Vwf Von Willebrand factor 0.8 13736

Eosinophil Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Eosinophil Ccl11 C-C motif chemokine 11; Eotaxin 0.5 14929
Eosinophil Ccl5 chemokine (C-C motif) ligand 5 4.2 10018
Eosinophil Ccr3α Probable C-C chemokine receptor type 3 0.0 >17742
Eosinophil Csf2 Granulocyte-macrophage colony-stimulating factor 0.0 >17742
Eosinophil Epx eosinophil peroxidase 0.0 >17742
Eosinophil Il5ra Interleukin-5 receptor subunit alpha 3.1 10786
Eosinophil Ear2 eosinophil-associated, ribonuclease A family, member 2 0.1 >17742

Erythrocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Erythrocyte Alas2 aminolevulinic acid synthase 2, erythroid  5.1 9517
Erythrocyte Cd36 CD36 antigen  578.8 250
Erythrocyte Cd44α CD44 antigen  0.4 15176
Erythrocyte Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 120.5 1347
Erythrocyte Cd55 CD55 molecule, decay accelerating factor for complement  20.8 5365
Erythrocyte cd59a CD59a antigen  63.7 2412
Erythrocyte Edrf1 erythroid differentiation regulatory factor 1 11.8 7125
Erythrocyte Epb41 erythrocyte membrane protein band 4.1 58.3 2579
Erythrocyte Epb41l2 erythrocyte membrane protein band 4.1 like 2 5.6 9285
Erythrocyte Gypa glycophorin A  0.0 >17742
Erythrocyte Gypc glycophorin C  1.7 12199
Erythrocyte Kel Kell blood group  0.0 >17742
Erythrocyte Kit KIT proto-oncogene receptor tyrosine kinase 5.9 9121
Erythrocyte Klf1 Kruppel-like factor 1 (erythroid) 1.8 12088
Erythrocyte Rhag Rhesus blood group-associated A glycoprotein 0.0 >17742
Erythrocyte Thrb thyroid hormone receptor beta 10.0 7626

Fibroblast Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Fibroblast Col1A1 collagen, type I, alpha 1 2.3 11542
Fibroblast Nt5eα 5' nucleotidase, ecto 101.2 1588
Fibroblast Pdgfrbα platelet derived growth factor receptor, beta polypeptide 7.8 8347
Fibroblast S100a4α S100 calcium binding protein A4 6.5β 8850
Myofibroblast Acta2α actin, alpha 2, smooth muscle, aorta 40.5 3418

Granular Cell of Afferent Arteriole Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Granular cell of afferent arteriole Adrb1 adrenergic receptor, beta 1 0.8 13927
Granular cell of afferent arteriole Ren1 renin 1 structural 111.3 1454
Granular cell of afferent arteriole Agtr1a angiotensin II receptor, type 1a 44.1 3204

Interstitial Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Interstitial Cells (Cortical)  Foxd1 forkhead box D1 0.5 15075
Interstitial Cells (Cortical)  Nt5eα 5' nucleotidase, ecto 101.2 1588
Interstitial Cells (Cortical)  Epo erythropoietin 0.1 >17742
Interstitial Cells (Medullary)  Ptgs2 prostaglandin-endoperoxide synthase 2 0.3 16278

Loop of Henle Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Short Loop Descending Limb Rgs5 regulator of G-protein signaling 5  6.5 8839
Short Loop Descending Limb Cox4i2 cytochrome c oxidase subunit IV isoform 2 0.5 14742
Short Loop Descending Limb Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 6348.0 9
Short Loop Descending Limb Parvb parvin, beta  0.6 14273
Short Loop Descending Limb Sh3rf2 SH3 domain containing ring finger 2  0.1 >17742
Short Loop Descending Limb Hey2 hairy/enhancer-of-split related with YRPW motif 2  0.4 15453
Long Descending Limb (Outer Medulla) Nkain4 Na+/K+ transporting ATPase interacting 4  0.7 14045
Long Descending Limb (Outer Medulla) Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) 1.3 12846
Long Descending Limb (Inner Medulla) Cxcl1 chemokine (C-X-C motif) ligand 1  5.6 9254
Long Descending Limb (Inner Medulla) Gem GTP binding protein (gene overexpressed in skeletal muscle)  9.5 7750
Long Descending Limb (Inner Medulla) Fga fibrinogen alpha chain  22.6 5102
Long Descending Limb (Inner Medulla) Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)  18.9 5663
Long Descending Limb (Inner Medulla) Thbs1 thrombospondin 1  10.4 7508
Long Descending Limb (Inner Medulla) Enc1 ectodermal-neural cortex 1  0.2 17023
Long Descending Limb (Inner Medulla) Spsb1 splA/ryanodine receptor domain and SOCS box containing 1  2.6 11273
Long Descending Limb (Inner Medulla) Arid5a AT rich interactive domain 5A (MRF1-like) 2.4 11424
Long Descending Limb (Inner Medulla) Cd40 CD40 antigen  1.9 11898
Long Descending Limb (Inner Medulla) Slc14a2α solute carrier family 14 (urea transporter), member 2, short isoform 20.1 5484
Thin Ascending Limb Nrgn neurogranin  0.6 14454
Thin Ascending Limb Rnf182 ring finger protein 182  0.1 >17742
Thin Ascending Limb Pcsk9 proprotein convertase subtilisin/kexin type 9  3.0 10865
Thin Ascending Limb Dram1 DNA-damage regulated autophagy modulator 1  4.9 9636
Thin Ascending Limb Mir24-2 microRNA 24-2  0.0 >17742
Thin Ascending Limb Arc activity regulated cytoskeletal-associated protein  2.8 11050
Thin Ascending Limb Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6  15.1 6357
Thin Ascending Limb Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 20.2 5469
Thin Ascending Limb Calcrl calcitonin receptor-like  9.3 7820
Thin Ascending Limb Clcnka chloride channel, voltage-sensitive Ka  60.4 2511
Thick Ascending Limb Umod uromodulin  1980.9 59
Thick Ascending Limb Slc12a1 solute carrier family 12, member 1  333.8 470
Thick Ascending Limb Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3  7.9 8309
Thick Ascending Limb Kcnt1 potassium channel, subfamily T, member 1  3.4 10640
Thick Ascending Limb Ptgs2 prostaglandin-endoperoxide synthase 2  0.3 16278
Thick Ascending Limb Irx2 Iroquois related homeobox 2 (Drosophila) 10.5 7480
Thick Ascending Limb Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B  88.9 1786
Thick Ascending Limb Lipg lipase, endothelial  0.4 15541
Thick Ascending Limb Tnni1 troponin I, skeletal, slow 1  0.1 >17742
Thick Ascending Limb Lrrc66 leucine rich repeat containing 66  10.6 7455
Thick Ascending Limb Igf1 insulin-like growth factor 1  5.7 9214

Macrophage Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Macrophage Adgre1α adhesion G protein-coupled receptor E1 2.7 11123
Macrophage Cd163 scavenger receptor cysteine-rich type 1 protein M130 isoform 1 precursor 0.3 16337
Macrophage Cd200 OX-2 membrane glycoprotein 61.3 2482
Macrophage Cd200r1 Cell surface glycoprotein CD200 receptor 1 0.1 >17742
Macrophage Cd68 macrosialin precursor 4.9 9629
Macrophage Csf1rα macrophage colony-stimulating factor 1 receptor 21.1β 5326
Macrophage Gata6 GATA 6 0.5 15009
Macrophage H2-Ab1α histocompatibility 2, class II antigen A, beta 1  210.7 772
Macrophage H2-Eb1α histocompatibility 2, class II antigen E beta 94.1 1706
Macrophage Il4raα interleukin-4 receptor subunit alpha precursor 7.7 8373
Macrophage Itgamα integrin alpha-M 0.8 13825
Macrophage Itgaxα integrin alpha-X precursor 0.7 14216
Macrophage Lgals3α galectin-3 78.6β 1998
Macrophage Ly6c1α lymphocyte antigen 6C1 248.5 643
Macrophage Pparg peroxisome proliferator activated receptor gamma  2.2 11621
Macrophage Siglecf sialic acid binding Ig-like lectin F  0.0 >17742

Macula Densa Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Macula Densa Ptgs2 prostaglandin-endoperoxide synthase 2 0.3 16278
Macula Densa Nos1 nitric oxide synthase 1, neuronal 0.1 >17742
Macula Densa Oxtr oxytocin receptor 0.2 17702

Mast Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Mast cell Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide 0.0 >17742
Mast cell Mcemp1 mast cell expressed membrane protein 1 0.5 14671
Mast cell Milr1 mast cell immunoglobulin like receptor 1 0.5 15119

Megakaryocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Megakaryocyte Cxcr4 chemokine (C-X-C motif)receptor 4  0.3 16398
Megakaryocyte Gp5 glycoprotein 5 (platelet) 0.0 >17742
Megakaryocyte Cxcr1 chemokine (C-X-C motif) receptor 1< 0.0 >17742
Megakaryocyte Cxcr2 chemokine (C-X-C motif) receptor 2 0.3 16371
Megakaryocyte Itga2b integrin alpha 2b  7.3 8518
Megakaryocyte Slamf1 signaling lymphocytic activation molecule family member 1 0.1 >17742
Megakaryocyte Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide 0.3 16395
Megakaryocyte Matk megakaryocyte-associated tyrosine kinase 0.6 14406

Mesangial Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Mesangial Cell Arid5b AT rich interactive domain 5B (MRF1-like) 5.4 9355
Mesangial Cell Ccr7 chemokine (C-C motif) receptor 7  0.3 16501
Mesangial Cell Fn1 fibronectin 1  4.2 10000
Mesangial Cell Gata3α GATA binding protein 3  6.3 8952
Mesangial Cell Itga8 integrin alpha 8  3.2 10747
Mesangial Cell Pawr PRKC, apoptosis, WT1, regulator  57.3 2627
Mesangial Cell Pdgfrbα platelet derived growth factor receptor, beta polypeptide  7.8 8347
Mesangial Cell Ptn pleiotrophin  2.1 11778
Mesangial Cell Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 16.0 6175
Mesangial Cell Tbx18α T-box18  0.0 >17742
Mesangial Cell Tekα endothelial-specific receptor tyrosine kinase  19.3 5600
Mesangial Cell Thy1 thymus cell antigen 1, theta  0.0 >17742

Monocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Monocyte Adgre1α adhesion G protein-coupled receptor E1 2.7 11123
Monocyte Ccr2 C-C chemokine receptor type 2 2.7 11124
Monocyte Cd14α Monocyte differentiation antigen CD14 5.3 9436
Monocyte Cd44α Cd44 Antigen 0.4 15176
Monocyte Csf1rα macrophage colony-stimulating factor 1 receptor 21.1β 5326
Monocyte Cx3cr1α CX3C chemokine receptor 1 1.2 12968
Monocyte Fcgr2b low affinity immunoglobulin gamma Fc region receptor II-b 47.2 3040
Monocyte Fcgr3α low affinity immunoglobulin gamma Fc region receptor III 6.9 8659
Monocyte Itgal integrin alpha-L isoform 0.7 14058
Monocyte Itgamα integrin alpha-M 0.8 13825
Monocyte Ly6c1α lymphocyte antigen 6C1 248.5 643
Monocyte Ly6c2 lymphocyte antigen 6C2 2.0 11847
Monocyte Ly6g lymphocyte antigen 6G 0.0 >17742
Monocyte Pecam1α platelet endothelial cell adhesion molecule 16.8 6021
Monocyte Ptprcα receptor-type tyrosine-protein phosphatase C 3.3 10651
Monocyte Sell L-selectin (lymphocyte selectin) 0.8 13836
Monocyte Spn leukosialin (sialophorin) 0.4 15256

Neuronal Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Neuronal Cell (Axon Only) Bdnf brain derived neurotrophic factor  3.1 10783
Neuronal Cell (Axon Only) Map2 microtubule-associated protein 2 2.9β 11014
Neuronal Cell (Axon Only) Nefl neurofilament, light polypeptide  0.6 14543
Neuronal Cell (Axon Only) Nes nestin  2.9 10938
Neuronal Cell (Axon Only) Ngf nerve growth factor  3.8 10288
Neuronal Cell (Axon Only) Slc18a2 solute carrier family 18 (vesicular monoamine), member 2  1.1 13132
Neuronal Cell (Axon Only) Stx1a syntaxin 1A (brain) 0.5 14797
Neuronal Cell (Axon Only) Vamp1 vesicle-associated membrane protein 1  6.2 8974

Pericyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Pericyte Acta2α actin, alpha 2, smooth muscle, aorta  40.5 3418
Pericyte Alpl alkaline phosphatase, liver/bone/kidney  336.1 463
Pericyte Angpt2 angiopoietin 2  6.7β 8766
Pericyte Cspg4 chondroitin sulfate proteoglycan 4  2.5 11356
Pericyte Mcam melanoma cell adhesion molecule  5.3 9396
Pericyte Mfge8 milk fat globule-EGF factor 8 protein  77.5 2027
Pericyte Nt5eα 5' nucleotidase, ecto  101.2 1588
Pericyte Tbx18α T-box18  0.0 >17742
Pericyte Tekα endothelial-specific receptor tyrosine kinase  19.3 5600

Plasma Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Plasma Cell Sdc1 syndecan 1 6.1 9046
Plasma Cell Irf4 Interferon response factor 4 0.1 >17742
Plasma Cell Cd38α CD38 antigen  8.5 8095
Plasma Cell Prdm1 PR domain containing 1, with ZNF domain 0.8 13905
Plasma Cell Cd93 CD93 antigen  2.8 11056
Plasma Cell Cd27 CD27 antigen  2.8 11118

Podocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Podocyte Nphs1 nephrin 1.9 11910
Podocyte Nphs2 podocin 53.3 2768
Podocyte Wt1 Wilm's tumor protein homolog 2.0 11837
Podocyte Cd2ap CD2-associated protein 10.2 7557
Podocyte podxl podocalyxin-like 27.4 4508

Polymorphonuclear Leukocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Polymorphonuclear Leukocyte Asb2 ankyrin repeat and SOCS box-containing 2 1.0 13279
Polymorphonuclear Leukocyte Itgb2 integrin beta 2 2.7 11141
Polymorphonuclear Leukocyte Csf3r colony stimulating factor 3 receptor (granulocyte) 0.2 16597
Polymorphonuclear Leukocyte Pram1 PML-RAR alpha-regulated adaptor molecule 1 0.0 >17742
Polymorphonuclear Leukocyte Adgre1α adhesion G protein-coupled receptor E1 2.7 11123

Proximal Tubule Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Proximal (General) Gsta2 glutathione S-transferase, alpha 2 (Yc2) 205.2 794
Proximal (General) Agxt2 alanine-glyoxylate aminotransferase 2  56.7 2644
Proximal (General) Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1  1729.3 75
Proximal (General) Cryl1 crystallin, lambda 1  472.1 310
Proximal (General) Glyat glycine-N-acyltransferase  591.4 243
Proximal (General) Sord sorbitol dehydrogenase  1183.3 98
Proximal (General) Pdzk1 PDZ domain containing 1  1049.9 116
Proximal (General) Upb1 ureidopropionase, beta  93.0 1726
Proximal (General) Sod3 superoxide dismutase 3, extracellular  301.8 519
Proximal (General) Hnf4a hepatic nuclear factor 4, alpha  143.0 1139
Proximal (S1) Nme4 NME/NM23 nucleoside diphosphate kinase 4  19.1 5631
Proximal (S1) Apoe apolipoprotein E  309.4 508
Proximal (S1) Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2  621.2 230
Proximal (S2) Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1  48.7 2973
Proximal (S2) Slco1a6 solute carrier organic anion transporter family, member 1a6  230.1 690
Proximal (S2) Hgd homogentisate 1, 2-dioxygenase  439.3 339
Proximal (S2) Slc17a3 solute carrier family 17 (sodium phosphate), member 3  726.1 182
Proximal (S2) Osgin1 oxidative stress induced growth inhibitor 1  88.1 1806
Proximal (S2) Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1  354.1 437
Proximal (S2) Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2  432.8 345
Proximal (S2) Kap kidney androgen regulated protein  29805.4 2
Proximal (S2) Haao 3-hydroxyanthranilate 3,4-dioxygenase  363.3 425
Proximal (S2) Slc7a13 solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 773.1 167
Proximal (S2) Ppic peptidylprolyl isomerase C  162.4 989
Proximal (S3) Tff3 trefoil factor 3, intestinal  0.0 >17742
Proximal (S3) Gng13 guanine nucleotide binding protein (G protein), gamma 13  0.1 >17742
Proximal (S3) Slc23a3 solute carrier family 23 (nucleobase transporters), member 3  9.1 7871
Proximal (S3) Gc group specific component  32.3 4025
Proximal (S3) Cacng5 calcium channel, voltage-dependent, gamma subunit 5  0.0 >17742
Proximal (S3) Tgfbi transforming growth factor, beta induced  5.9 9090
Proximal (S3) Slc22a13 solute carrier family 22 (organic cation transporter), member 13 85.7 1845
Proximal (S3) Rbp4 retinol binding protein 4, plasma  2.4 11418

Smooth Muscle Cell Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Smooth Muscle Cell Acta2α actin, alpha 2, smooth muscle, aorta  40.5 3418
Smooth Muscle Cell Cnn1 calponin 1  1.9 11979
Smooth Muscle Cell Myh11 myosin, heavy polypeptide 11, smooth muscle 3.4 10631
Smooth Muscle Cell Smtn smoothelin  37.5β 3634
Smooth Muscle Cell Tagln transgelin  27.9 4450

T-lymphocyte Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
T-lymphocyte (helper) Cd4α T-cell surface glycoprotein CD4 0.5 14893
T-lymphocyte (helper) Cd40lg T-cell antigen Gp39 0.4 15364
T-lymphocyte (helper) Il4raα interleukin 4 receptor, alpha  7.7 8373
T-lymphocyte (natural killer) Cd4α T-cell surface glycoprotein CD4 0.5 14893
T-lymphocyte (natural killer) Cd8aα CD8 antigen, alpha chain  1.3 12713
T-lymphocyte (natural killer) Fcgr3α Low affinity immunoglobulin gamma Fc region receptor III 6.9 8659
T-lymphocyte (natural killer) Gzma Autocrine thymic lymphoma granzyme-like serine protease 0.2 17165
T-lymphocyte (natural killer) Klrb1c Killer cell lectin-like receptor subfamily B member 1C 0.1 >17742
T-lymphocyte (natural killer) Ncam1 Neural cell adhesion molecule 1 1.5 12393
T-lymphocyte (regulatory) Cd4α T-cell surface glycoprotein CD4 0.5 14893
T-lymphocyte (regulatory) Foxp3 Forkhead box protein P3 0.2 16600
T-lymphocyte (regulatory) Il2ra Interleukin-2 receptor subunit alpha 0.0 >17742

Transitional Epithelium Markers

Cell Type Gene Symbol Annotation Mean TPM
(n=3 mice)
 Rank
Transitional Epithelium Upk1a uroplakin 1A  7.4 8472
Transitional Epithelium Upk1b uroplakin 1B  4.4 9924
Transitional Epithelium Upk2 uroplakin 2  2.9 11019
Transitional Epithelium Upk3a uroplakin 3A  11.0 7320
Transitional Epithelium Upk3b uroplakin 3B  1.6 12335



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