ESBL Epithelial Systems Biology Laboratory, NHLBI

Entry Page to PKA Network

Source: Isobe K, Jung HJ, Yang CR, Claxton J, Sandoval P, Burg MB, Raghuram V, Knepper MA. Systems-level identification of PKA-dependent signaling in epithelial cells. Proc Natl Acad Sci U S A. 2017; 114: E8875-E8884. PMID: 28973931

(Network is divided up into multiple subnetworks based on physiological responses regulated. Click on individual Physiological Responses to reveal subnetworks with documentation.)

Calcium mobilization Actin Dynamics MAP Kinase Inhibition Inhibition of apoptosis Altered aquaporin-2 phosphorylation PKA Increases Aquaporin-2 Exocytosis PKA Decreases Aquaporin-2 Endocytosis and Degradation PKA Decreases Aquaporin-2 Endocytosis and Degradation PKA Increases Transcription of Aquaporin-2 Gene

*Basophilic phosphorylation sites with decreased phospho-occupancy in PKA double knockout cells (both PKA catalytic subunit genes deleted in mouse mpkCCD cells by CRISPR-Cas9)

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