National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Cell Cycle-Associated Genes (KEGG)

The gene list on this page consists of all genes in the KEGG "Cell cycle - Homo sapiens (human)" pathway.

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

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Cell Cycle Genes (KEGG)

Gene symbol Annotation UniProt No.
ABL1  ABL proto-oncogene 1, non-receptor tyrosine kinase  P00519.4
ANAPC1  anaphase promoting complex subunit 1  Q9H1A4.1
ANAPC10  anaphase promoting complex subunit 10  Q9UM13.1
ANAPC11  anaphase promoting complex subunit 11  Q9NYG5.1
ANAPC13  anaphase promoting complex subunit 13  Q9BS18.1
ANAPC2  anaphase promoting complex subunit 2  Q9UJX6.1
ANAPC4  anaphase promoting complex subunit 4  Q9UJX5.2
ANAPC5  anaphase promoting complex subunit 5  Q9UJX4.2
ANAPC7  anaphase promoting complex subunit 7  Q9UJX3.5
ATM  ATM serine/threonine kinase  Q13315.4
ATR  ATR serine/threonine kinase  Q13535.3
BUB1  BUB1 mitotic checkpoint serine/threonine kinase  O43683.1
BUB1B  BUB1 mitotic checkpoint serine/threonine kinase B  O60566.3
BUB3  BUB3, mitotic checkpoint protein  O43684.1
CCNA1  cyclin A1  P78396.1
CCNA2  cyclin A2  P20248.2
CCNB1  cyclin B1  P14635.1
CCNB2  cyclin B2  O95067.1
CCNB3  cyclin B3  Q8WWL7.2
CCND1  cyclin D1  P24385.1
CCND2  cyclin D2  P30279.1
CCND3  cyclin D3  P30281.2
CCNE1  cyclin E1  P24864.2
CCNE2  cyclin E2  O96020.1
CCNH  cyclin H  P51946.1
CDC14A  cell division cycle 14A  Q9UNH5.1
CDC14B  cell division cycle 14B  O60729.1
CDC16  cell division cycle 16  Q13042.2
CDC20  cell division cycle 20  Q12834.2
CDC23  cell division cycle 23  Q9UJX2.3
CDC25A  cell division cycle 25A  P30304.2
CDC25B  cell division cycle 25B  P30305.2
CDC25C  cell division cycle 25C  P30307.2
CDC26  cell division cycle 26  Q8NHZ8.1
CDC27  cell division cycle 27  P30260.2
CDC45  cell division cycle 45  O75419.1
CDC6  cell division cycle 6  Q99741.1
CDC7  cell division cycle 7  O00311.1
CDK1  cyclin dependent kinase 1  P06493.3
CDK2  cyclin dependent kinase 2  P24941.2
CDK4  cyclin dependent kinase 4  P11802.2
CDK6  cyclin dependent kinase 6  Q00534.1
CDK7  cyclin dependent kinase 7  P50613.1
CDKN1A  cyclin dependent kinase inhibitor 1A  P38936.3
CDKN1B  cyclin dependent kinase inhibitor 1B  P46527.1
CDKN1C  cyclin dependent kinase inhibitor 1C  P49918.1
CDKN2A  cyclin dependent kinase inhibitor 2A  Q8N726.2
CDKN2B  cyclin dependent kinase inhibitor 2B  P42772.1
CDKN2C  cyclin dependent kinase inhibitor 2C  P42773.1
CDKN2D  cyclin dependent kinase inhibitor 2D  P55273.1
CHEK1  checkpoint kinase 1  O14757.2
CHEK2  checkpoint kinase 2  O96017.1
CREBBP  CREB binding protein  Q92793.3
CUL1  cullin 1  Q13616.2
DBF4  DBF4 zinc finger  Q9UBU7.1
E2F1  E2F transcription factor 1  Q01094.1
E2F2  E2F transcription factor 2  Q14209.1
E2F3  E2F transcription factor 3  O00716.1
E2F4  E2F transcription factor 4  Q16254.2
E2F5  E2F transcription factor 5  Q15329.1
EP300  E1A binding protein p300  Q09472.2
ESPL1  extra spindle pole bodies like 1, separase  Q14674.3
FZR1  fizzy and cell division cycle 20 related 1  Q9UM11.2
GADD45A  growth arrest and DNA damage inducible alpha  P24522.1
GADD45B  growth arrest and DNA damage inducible beta  O75293.1
GADD45G  growth arrest and DNA damage inducible gamma  O95257.1
GSK3B  glycogen synthase kinase 3 beta  P49841.2
HDAC1  histone deacetylase 1  Q13547.1
HDAC2  histone deacetylase 2  Q92769.2
MAD1L1  MAD1 mitotic arrest deficient like 1  Q9Y6D9.2
MAD2L1  mitotic arrest deficient 2 like 1  Q13257.1
MAD2L2  mitotic arrest deficient 2 like 2  Q9UI95.2
MCM2  minichromosome maintenance complex component 2  P49736.4
MCM3  minichromosome maintenance complex component 3  P25205.3
MCM4  minichromosome maintenance complex component 4  P33991.5
MCM5  minichromosome maintenance complex component 5  P33992.5
MCM6  minichromosome maintenance complex component 6  Q14566.1
MCM7  minichromosome maintenance complex component 7  P33993.4
MDM2  MDM2 proto-oncogene  Q00987.1
MYC  MYC proto-oncogene, bHLH transcription factor  P01106.1
ORC1  origin recognition complex subunit 1  Q13415.2
ORC2  origin recognition complex subunit 2  Q13416.2
ORC3  origin recognition complex subunit 3  Q9UBD5.1
ORC4  origin recognition complex subunit 4  O43929.2
ORC5  origin recognition complex subunit 5  O43913.1
ORC6  origin recognition complex subunit 6  Q9Y5N6.1
PCNA  proliferating cell nuclear antigen  P12004.1
PKMYT1  protein kinase, membrane associated tyrosine/threonine 1  Q99640.1
PLK1  polo like kinase 1  P53350.1
PRKDC  protein kinase, DNA-activated, catalytic polypeptide  P78527.3
PTTG1  pituitary tumor-transforming 1  O95997.1
PTTG2  pituitary tumor-transforming 2  Q9NZH5.2
RAD21  RAD21 cohesin complex component  O60216.2
RB1  RB transcriptional corepressor 1  P06400.2
RBL1  RB transcriptional corepressor like 1  P28749.3
RBL2  RB transcriptional corepressor like 2  Q08999.3
RBX1  ring-box 1  P62877.1
SFN  stratifin  P31947.1
SKP1  S-phase kinase associated protein 1  P63208.2
SKP2  S-phase kinase associated protein 2  Q13309.2
SMAD2  SMAD family member 2  Q15796.1
SMAD3  SMAD family member 3  P84022.1
SMAD4  SMAD family member 4  Q13485.1
SMC1A  structural maintenance of chromosomes 1A  Q14683.2
SMC1B  structural maintenance of chromosomes 1B  Q8NDV3.2
SMC3  structural maintenance of chromosomes 3  Q9UQE7.2
STAG1  stromal antigen 1  Q8WVM7.3
STAG2  stromal antigen 2  Q8N3U4.3
TFDP1  transcription factor Dp-1  Q14186.1
TFDP2  transcription factor Dp-2  Q14188.2
TGFB1  transforming growth factor beta 1  P01137.2
TGFB2  transforming growth factor beta 2  P61812.1
TGFB3  transforming growth factor beta 3  P10600.1
TP53  tumor protein p53  P04637.4
TTK  TTK protein kinase  P33981.2
WEE1  WEE1 G2 checkpoint kinase  P30291.2
WEE2  WEE1 homolog 2  P0C1S8.2
YWHAB  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  P31946.3
YWHAE  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  P62258.1
YWHAG  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma  P61981.2
YWHAH  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta  Q04917.4
YWHAQ  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta  P27348.1
YWHAZ  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  P63104.1
ZBTB17  zinc finger and BTB domain containing 17  Q13105.3

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Gene symbol Annotation UniProt No.