National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


EMT Signature Genes - Downregulated

Curated from: Gröger CJ, Grubinger M, Waldhör T, Vierlinger K, Mikulits W. Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression. PLoS One. 2012;7(12):e51136. PubMed PMID: 23251436

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

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Gene Symbol Protein Name Uniprot Number
Ablim1 actin-binding LIM protein 1  Q8K4G5
Adrb2 beta-2 adrenergic receptor P18762
Agr2 anterior gradient protein 2 homolog  O88312
Aldh1a3 aldehyde dehydrogenase family 1 member A3 Q9JHW9
Ank3 ankyrin-3  G5E8K5
Bik bcl-2-interacting killer O70337
C10orf10 chromosome 10 open reading frame 10 Q8K2F3
Ca2 carbonic anhydrase 2 P00920
Cd24 signal transducer CD24 P24807
Cdh1 cadherin-1 preproprotein P09803
Cds1 phosphatidate cytidylyltransferase 1 P98191
Ctsl2 cathepsin L2 O60911
Cxadr coxsackievirus and adenovirus receptor homolog P97792
Cxcl16 C-X-C motif chemokine 16  Q8BSU2
Dsg3 desmoglein-3 preproprotein O35902
Elf3 ETS-related transcription factor Elf-3  Q3UPW2
Epcam epithelial cell adhesion molecule  Q99JW5
Epha1 ephrin type-A receptor 1  Q60750
Fam169a soluble lamin-associated protein of 75 kDa Q5XG69
Fgfr2 fibroblast growth factor receptor 2  P21803
Fgfr3 fibroblast growth factor receptor 3  Q61851
Fst follistatin FST288  P47931
Fxyd3 FXYD domain-containing ion transport regulator 3  Q61835
Gjb3 gap junction beta-3 protein P28231
Gpx3 glutathione peroxidase 3  P46412
Ifi30 gamma-interferon-inducible lysosomal thiol reductase  Q9ESY9
Il18 interleukin-18  P70380
Jup junction plakoglobin Q02257
Klk10 kallikrein-10 null
Klk7 kallikrein-7 preproprotein Q91VE3
Krt15 keratin, type I cytoskeletal 15 Q61414
Krt17 keratin, type I cytoskeletal 17 Q9QWL7
Lad1 ladinin-1 P57016
Lsr lipolysis-stimulated lipoprotein receptor  Q99KG5
Map7 ensconsin  O88735
Mbp myelin basic protein  P04370
Mpzl2 myelin protein zero-like protein 2  O70255
Mtus1 microtubule-associated tumor suppressor 1 homolog  Q5HZI1
Ocln occludin  Q61146
Ovol2 transcription factor Ovo-like 2  Q8CIV7
Pkp2 plakophilin-2 Q3TIY5
Pls1 plastin-1 Q3V0K9
Plxnb1 plexin-B1  Q8CJH3
Ppl periplakin Q9R269
Prrg4 transmembrane gamma-carboxyglutamic acid protein 4  Q8BGN6
Prss8 prostasin  Q9ESD1
Rapgef5 rap guanine nucleotide exchange factor 5  Q8C0Q9
Rhod rho-related GTP-binding protein RhoD  P97348
S100P S100 calcium binding protein P P25815
Serpinb1 leukocyte elastase inhibitor Q9D154
Slc27a2 very long-chain acyl-CoA synthetase O35488
Slc7a5 large neutral amino acids transporter small subunit 1 Q9Z127
Slpi antileukoproteinase  P97430
Smpdl3b acid sphingomyelinase-like phosphodiesterase 3b  P58242
Sorl1 sortilin-related receptor  O88307
Spint1 kunitz-type protease inhibitor 1  Q9R097
St6galnac2 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 P70277
Syk tyrosine-protein kinase SYK P48025
Tmem30b cell cycle control protein 50B Q8BHG3
Tpd52l1 tumor protein D53  O54818
Tspan1 tetraspanin-1 Q99J59
Zhx2 zinc fingers and homeoboxes protein 2 Q8C0C0
Znf165 zinc finger protein 165 P49910

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Gene Symbol Protein Name Uniprot Number