National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


EMT Signature Genes - Upregulated

Curated from: Gröger CJ, Grubinger M, Waldhör T, Vierlinger K, Mikulits W. Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression. PLoS One. 2012;7(12):e51136. PubMed PMID: 23251436

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

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Gene Symbol Protein Name UniProt Number
12br tropomyosin alpha-1 chain  P58771
Abca1 phospholipid-transporting ATPase ABCA1 P41233
Adam12 disintegrin and metalloproteinase domain-containing protein 12 preproprotein Q61824
C5orf13 chromosome 5 open reading frame 13 Q9P187
Cdh11 cadherin-11 preproprotein P55288
Cdh2 cadherin-2 preproprotein P15116
Cdk14 cyclin-dependent kinase 14  O35495
Cdkn2c cyclin-dependent kinase 4 inhibitor C Q60772
Col1a1 collagen alpha-1(I) chain preproprotein P11087
Col3a1 collagen alpha-1(III) chain preproprotein P08121
Col5a1 collagen alpha-1(V) chain  O88207
Col6a1 collagen alpha-1(VI) chain  Q04857
Col6a3 collagen alpha-3(VI) chain  J3QQ16 
Ctgf connective tissue growth factor P29268
Cyp1b1 cytochrome P450 1B1  Q64429
Dcn decorin preproprotein P28654
Dlc1 rho GTPase-activating protein 7  Q9R0Z9
Eml1 echinoderm microtubule-associated protein-like 1  Q05BC3
Emp3 epithelial membrane protein 3 O35912
Fbln1 fibulin-1  Q08879
Fbln5 fibulin-5  Q9WVH9
Fbn1 fibrillin-1 preproprotein Q61554
Fgf2 fibroblast growth factor 2 P15655
Fgfr1 fibroblast growth factor receptor 1  P16092
Fn1 fibronectin  P11276
Fstl1 follistatin-related protein 1  Q62356
Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 Q6P9S7
Has2 hyaluronan synthase 2 P70312
Igfbp3 insulin-like growth factor-binding protein 3  P47878
Il1r1 interleukin-1 receptor type 1  P13504
Lamc2 laminin subunit gamma-2  Q61092
Lox protein-lysine 6-oxidase preproprotein P28301
Ltbp1 latent-transforming growth factor beta-binding protein 1  Q8CG19
Ltbp2 latent-transforming growth factor beta-binding protein 2  O08999
Lum lumican P51885
Map1b microtubule-associated protein 1B P14873
Mme neprilysin Q61391
Mmp2 72 kDa type IV collagenase preproprotein P33434
Myl9 myosin regulatory light polypeptide 9 Q9CQ19
Nid2 nidogen-2  O88322
Nr2f1 COUP transcription factor 1  Q60632
Nrp1 neuropilin-1  P97333
Plat tissue-type plasminogen activator preproprotein P11214
Pmp22 peripheral myelin protein 22  P16646
Ppap2b phosphatidic acid phosphatase type 2B Q99JY8
Prkca protein kinase C alpha type P20444
Ptger2 prostaglandin E2 receptor EP2 subtype Q62053
Ptx3 pentraxin-related protein PTX3  P48759
Reck reversion-inducing cysteine-rich protein with Kazal motifs  Q9Z0J1
Rgs4 regulator of G-protein signaling 4 O08899
Serpine1 plasminogen activator inhibitor 1  P22777
Serpine2 glia-derived nexin  Q07235
Slc22a4 solute carrier family 22 member 4  Q9Z306
Spock1 testican-1  Q62288
Srgn serglycin  P13609
Sulf1 extracellular sulfatase Sulf-1 Q8K007
Syne1 nesprin-1  Q6ZWR6
Syt11 synaptotagmin-11 Q9R0N3
Tagln transgelin P37804
Tfpi tissue factor pathway inhibitor  O54819
Tgm2 protein-glutamine gamma-glutamyltransferase 2 P21981
Tmem158 transmembrane protein 158  Q6F5E0
Tnfaip6 tumor necrosis factor-inducible gene 6 protein  O08859
Tuba1a tubulin alpha-1A chain P68369
Vcan versican core protein  Q62059
Vim vimentin P20152
Wnt5a protein Wnt-5a  P22725
Zeb1 zinc finger E-box-binding homeobox 1  Q64318

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Gene Symbol Protein Name UniProt Number