National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Glucocorticoid-Induced Genes

Compendium of glucocorticoid-induced genes curated from three sources:
1. Wang et al. Proc Natl Acad Sci U S A. 2004; 101: 15603-8, PMID: 15501915.
2. Phuc Le et al. PLoS Genet. 2005; 1: e16, PMID: 16110340.
3. Reddy et al, Genome Res. 2009; 19: 2163-71, PMID: 19801529.

Database was created by Molly Bingham, Angela Mak, and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

To search, use browser's Find command (Ctrl-F)

Gene Symbol Annotation UniProt Number Source
Abca1 phospholipid-transporting ATPase ABCA1 P41233 Phuc Le et al., 2005
Abhd2 monoacylglycerol lipase ABHD2 Q9QXM0 Wang et al., 2004
Abi1 abl interactor 1 Q8CBW3 Phuc Le et al., 2005
Adgrf4 adhesion G protein-coupled receptor F4  Q9D2L6 Wang et al., 2004
Adh1 alcohol dehydrogenase 1 P00329 Phuc Le et al., 2005
Adm adrenomedullin  P97297 Phuc Le et al., 2005
Ahnak neuroblast differentiation-associated protein AHNAK Q09666 Reddy et al., 2009
Akap13 A-kinase anchor protein 13 E9Q394 Wang et al., 2004
Alox5ap arachidonate 5-lipoxygenase-activating protein P20292 Reddy et al., 2009
Angptl4 angiopoietin-related protein 4  Q9Z1P8 Wang et al., 2004; Reddy et al., 2009
Ankrd1 ankyrin repeat domain-containing protein 1 Q9CR42 Wang et al., 2004
Apoa2 apolipoprotein A-II preproprotein P09813 Phuc Le et al., 2005
Arrdc2 arrestin domain-containing protein 2 Q8TBH0 Reddy et al., 2009
As3mt arsenite methyltransferase Q91WU5 Phuc Le et al., 2005
Atp6ap1 V-type proton ATPase subunit S1   Q9R1Q9 Phuc Le et al., 2005
B2m beta-2-microglobulin  P01887 Phuc Le et al., 2005
B3gnt5 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Q8BGY6 Wang et al., 2004
Bag3 BAG family molecular chaperone regulator 3 O95817 Reddy et al., 2009
Bcl6 B-cell lymphoma 6 protein  P41182 Reddy et al., 2009
Bdkrb2 B2 bradykinin receptor P30411 Reddy et al., 2009
Birc2 baculoviral IAP repeat-containing protein 2 Q62210 Wang et al., 2004
Birc3 baculoviral IAP repeat-containing protein 3 Q13489 Reddy et al., 2009
Brd2 bromodomain-containing protein 2 Q7JJ13 Phuc Le et al., 2005
Cat catalase P24270 Phuc Le et al., 2005
Cavin2 caveolae-associated protein 2 Q63918 Wang et al., 2004; Reddy et al., 2009
Ccl20 C-C motif chemokine 20   O89093 Wang et al., 2004
Cdc42ep3 cdc42 effector protein 3 Q9CQC5 Wang et al., 2004
Cdkn1c cyclin-dependent kinase inhibitor 1C  P49919 Wang et al., 2004
Cebpb CCAAT/enhancer-binding protein beta isoform c P17676 Reddy et al., 2009
Cebpd CCAAT/enhancer-binding protein delta P49716 Reddy et al., 2009
Chic2 cysteine-rich hydrophobic domain-containing protein 2 Q9D9G3 Phuc Le et al., 2005
Cidec cell death activator CIDE-3  Q96AQ7 Reddy et al., 2009
Ckb creatine kinase B-type  P12277 Reddy et al., 2009
Cks1b cyclin-dependent kinases regulatory subunit 1 P61025 Phuc Le et al., 2005
Comt catechol O-methyltransferase O88587 Phuc Le et al., 2005
Cpeb4 cytoplasmic polyadenylation element-binding protein 4  Q7TN98 Wang et al., 2004
Dbi acyl-CoA-binding protein  P31786 Phuc Le et al., 2005
Ddx5 probable ATP-dependent RNA helicase DDX5 Q61656 Phuc Le et al., 2005
Degs1 sphingolipid delta(4)-desaturase DES1  O09005 Phuc Le et al., 2005
Dnajc15 dnaJ homolog subfamily C member 15 Q78YY6 Wang et al., 2004
Dner delta and Notch-like epidermal growth factor-related receptor  Q8JZM4 Wang et al., 2004
Dusp1 dual specificity protein phosphatase 1 P28562 Reddy et al., 2009
Edn1 endothelin-1  preproprotein P05305 Reddy et al., 2009
Edn2 endothelin-2 preproprotein P22389 Wang et al., 2004; Reddy et al., 2009
Ell2 RNA polymerase II elongation factor ELL2 O00472 Reddy et al., 2009
Entpd2 ectonucleoside triphosphate diphosphohydrolase 2  Q9Y5L3 Reddy et al., 2009
Epb41l4b band 4.1-like protein 4B  Q9JMC8 Wang et al., 2004; Phuc Le et al., 2005
Ern1 serine/threonine-protein kinase/endoribonuclease IRE1  O75460 Reddy et al., 2009
Etnk2 ethanolamine kinase 2 A7MCT6 Wang et al., 2004
Fgd4 FYVE, RhoGEF and PH domain-containing protein 4  Q91ZT5 Wang et al., 2004
Fkbp5 peptidyl-prolyl cis-trans isomerase FKBP5 Q64378 Wang et al., 2004
Fnta farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q61239 Phuc Le et al., 2005
Fosl2 fos-related antigen 2 P15408 Reddy et al., 2009
Fzd2 frizzled-2  Q14332 Reddy et al., 2009
Gadd45b growth arrest and DNA damage-inducible protein GADD45 beta P22339 Wang et al., 2004
Gas1 growth arrest-specific protein 1 Q01721 Phuc Le et al., 2005
Gdf15 growth/differentiation factor 15 preproprotein Q99988 Reddy et al., 2009
Gnmt glycine N-methyltransferase  Q9QXF8 Phuc Le et al., 2005
Gpr153 probable G-protein coupled receptor 153  Q8K0Z9 Wang et al., 2004
Hgd homogentisate 1,2-dioxygenase O09173 Phuc Le et al., 2005
Hmgcs2 hydroxymethylglutaryl-CoA synthase, mitochondrial  P54869 Phuc Le et al., 2005
Hsd17b12 very-long-chain 3-oxoacyl-CoA reductase O70503 Phuc Le et al., 2005
Hsd3b4 NADPH-dependent 3-keto-steroid reductase Hsd3b4 Q61767 Phuc Le et al., 2005
Hsp90ab1 heat shock protein HSP 90-beta P11499 Phuc Le et al., 2005
Id3 DNA-binding protein inhibitor ID-3 Q02535 Reddy et al., 2009
Idh1 isocitrate dehydrogenase [NADP] cytoplasmic O88844 Phuc Le et al., 2005
Ier2 immediate early response gene 2 protein P17950 Phuc Le et al., 2005
Igfbp1 insulin-like growth factor-binding protein 1  P47876 Phuc Le et al., 2005; Reddy et al., 2009
Il6St interleukin-6 receptor subunit beta isoform 7 P40189 Reddy et al., 2009
Ip6k3 inositol hexakisphosphate kinase 3 Q8BWD2 Wang et al., 2004
Irs2 insulin receptor substrate 2 P81122 Wang et al., 2004
Itpkc inositol-trisphosphate 3-kinase C Q96DU7 Reddy et al., 2009
Klf5 Krueppel-like factor 5  Q13887 Reddy et al., 2009
Klf9 Krueppel-like factor 9 Q13886 Reddy et al., 2009
Lipc hepatic triacylglycerol lipase  P27656 Phuc Le et al., 2005
Lrrc8a volume-regulated anion channel subunit LRRC8A Q8IWT6 Wang et al., 2004; Reddy et al., 2009
Lrrfip1 leucine-rich repeat flightless-interacting protein 1  Q3UZ39 Wang et al., 2004
Mest mesoderm-specific transcript protein   Q07646 Phuc Le et al., 2005
Mfge8 lactadherin   P21956 Wang et al., 2004
Mgam maltase-glucoamylase, intestinal  O43451 Wang et al., 2004
Midn midnolin  Q504T8 Reddy et al., 2009
Mknk2 MAP kinase-interacting serine/threonine-protein kinase 2 Q8CDB0 Phuc Le et al., 2005
Msrb1 methionine-R-sulfoxide reductase B1 Q9JLC3 Phuc Le et al., 2005
Mt1X metallothionein-1X P80297 Reddy et al., 2009
Mt2a metallothionein-2 P02795 Reddy et al., 2009
Mtch2 mitochondrial carrier homolog 2  Q791V5 Phuc Le et al., 2005
Nfkbia NF-kappa-B inhibitor alpha P25963 Reddy et al., 2009
Nol3 nucleolar protein 3 isoform E O60936 Reddy et al., 2009
Oat ornithine aminotransferase, mitochondrial  P29758 Phuc Le et al., 2005
Otulinl Inactive ubiquitin thioesterase Q3PVT5 Reddy et al., 2009
Pard6b partitioning defective 6 homolog beta Q9BYG5 Reddy et al., 2009
Pck1 phosphoenolpyruvate carboxykinase, cytosolic [GTP] Q9Z2V4 Phuc Le et al., 2005
Per1 period circadian protein homolog 1 O15534 Reddy et al., 2009
Per2 period circadian protein homolog 2 O15055 Reddy et al., 2009
Plin2 perilipin-2  P43883 Phuc Le et al., 2005
Pou5f1 POU domain, class 5, transcription factor 1  P20263 Wang et al., 2004
Ppp1r14c protein phosphatase 1 regulatory subunit 14C Q8R4S0 Wang et al., 2004
Ppp1r15b protein phosphatase 1 regulatory subunit 15B Q5SWA1 Reddy et al., 2009
Prrg4 transmembrane gamma-carboxyglutamic acid protein 4  Q8BGN6 Wang et al., 2004
Psma6 proteasome subunit alpha type-6 Q9QUM9 Phuc Le et al., 2005
Ptp4a2 protein tyrosine phosphatase type IVA 2 O70274 Phuc Le et al., 2005
Pxn paxillin  P49023 Reddy et al., 2009
Rab11a ras-related protein Rab-11A P62492 Phuc Le et al., 2005
Rabggtb geranylgeranyl transferase type-2 subunit beta  P53612 Phuc Le et al., 2005
Rassf9 ras association domain-containing protein 9 O75901 Reddy et al., 2009
Rgs2 regulator of G-protein signaling 2 O08849 Wang et al., 2004
Rhob rho-related GTP-binding protein RhoB P62745 Reddy et al., 2009
Rhobtb2 rho-related BTB domain-containing protein 2  Q9BYZ6 Reddy et al., 2009
Rnf10 RING finger protein 10  Q3UIW5 Phuc Le et al., 2005
Rnf11 RING finger protein 11 Q9QYK7 Phuc Le et al., 2005
Rrad GTP-binding protein RAD P55042 Reddy et al., 2009
S100p protein S100-P P25815 Wang et al., 2004
Scnn1a amiloride-sensitive sodium channel subunit alpha  Q61180 Wang et al., 2004
Sec14l1 SEC14-like protein 1  A8Y5H7 Wang et al., 2004
Serinc3 serine incorporator 3  Q9QZI9 Phuc Le et al., 2005
Serpina1a alpha-1-antitrypsin 1-1   P07758 Phuc Le et al., 2005
Slc19a2 thiamine transporter 1  Q9EQN9 Wang et al., 2004; Reddy et al., 2009
Slc22a5 solute carrier family 22 member 5  O76082 Reddy et al., 2009
Slc26a2 sulfate transporter Q62273 Wang et al., 2004
Snai2 zinc finger protein SNAI2 P97469 Wang et al., 2004
Spink13 serine protease inhibitor Kazal-type 13  Q3UTS8 Wang et al., 2004
Spry1 protein sprouty homolog 1 Q9QXV9 Wang et al., 2004
Srgn serglycin  P13609 Wang et al., 2004; Reddy et al., 2009
Stom stomatin P54116 Wang et al., 2004; Reddy et al., 2009
Stub1 E3 ubiquitin-protein ligase CHIP Q9WUD1 Phuc Le et al., 2005
Tfcp2l1 transcription factor CP2-like protein 1 Q9NZI6 Reddy et al., 2009
Tgfbr3 transforming growth factor beta receptor type 3  O88393 Wang et al., 2004
Thbd thrombomodulin  P15306 Wang et al., 2004; Reddy et al., 2009
Thbs1 thrombospondin-1  P07996 Reddy et al., 2009
Tigd2 tigger transposable element-derived protein 2 Q4W5G0 Reddy et al., 2009
Tiparp protein mono-ADP-ribosyltransferase TIPARP Q7Z3E1 Reddy et al., 2009
Tnfaip3 tumor necrosis factor alpha-induced protein 3  Q60769 Wang et al., 2004; Reddy et al., 2009
Tns4 tensin-4  Q8BZ33 Wang et al., 2004
Tpst2 protein-tyrosine sulfotransferase 2  O88856 Phuc Le et al., 2005
Tsc22d3 TSC22 domain family protein 3 (GILZ) Q9Z2S7 Wang et al., 2004
Txn1 thioredoxin P10639 Phuc Le et al., 2005
Ugcg ceramide glucosyltransferase O88693 Phuc Le et al., 2005
Uox uricase P25688 Phuc Le et al., 2005
Wnt5a protein Wnt-5a   P22725 Phuc Le et al., 2005
Ywhae 14-3-3 protein epsilon P62259 Phuc Le et al., 2005
Zc3h12a endoribonuclease ZC3H12A  Q5D1E8 Reddy et al., 2009
Zfand5 AN1-type zinc finger protein 5 O76080 Reddy et al., 2009
Zfp36 mRNA decay activator protein ZFP36 P26651 Reddy et al., 2009
Znf281 zinc finger protein 281  Q9Y2X9 Reddy et al., 2009
Znf57 zinc finger protein 57  Q68EA5 Reddy et al., 2009

To search, use browser's Find command (Cntrl F)

Gene Symbol Annotation UniProt Number Source

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