The gene list on this page consists of all genes in the KEGG "Insulin Signaling Pathway and KEGG "ErbB Signaling Pathway".
Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.
| Gene Symbol | Annotation | UniProt Number |
| Abl1 | tyrosine-protein kinase ABL1 | P00520 |
| Abl2 | tyrosine-protein kinase ABL2 | Q4JIM5 |
| Acaca | acetyl-CoA carboxylase alpha | Q5SWU9 |
| Acacb | acetyl-CoA carboxylase beta | E9Q4Z2 |
| Akt1 | AKT serine/threonine kinase 1 | P31750 |
| Akt2 | AKT serine/threonine kinase 2 | Q60823 |
| Akt3 | AKT serine/threonine kinase 3 | Q9WUA6 |
| Araf | A-Raf proto-oncogene, serine/threonine kinase | P04627 |
| Areg | amphiregulin | P31955 |
| Bad | BCL2 associated agonist of cell death | Q61337 |
| Braf | B-Raf proto-oncogene, serine/threonine kinase | P28028 |
| Btc | betacellulin preproprotein | Q05928 |
| Bub1b-Pak6 | BUB1B-PAK6 readthrough | H3BTB9 |
| Calm1 | calmodulin 1 | P0DP26 |
| Calm2 | calmodulin 2 | P0DP27 |
| Calm3 | calmodulin 3 | P0DP28 |
| Calml3 | calmodulin like 3 | Q9D6P8 |
| Calml4 | calmodulin like 4 | Q91WQ9 |
| Camk2a | calcium/calmodulin-dependent protein kinase type II subunit alpha | P11798 |
| Camk2b | calcium/calmodulin-dependent protein kinase type II subunit beta | P28652 |
| Camk2d | calcium/calmodulin-dependent protein kinase type II subunit delta | Q6PHZ2 |
| Camk2g | calcium/calmodulin-dependent protein kinase type II subunit gamma | Q923T9 |
| Cbl | Cbl proto-oncogene | P22682 |
| Cblb | Cbl proto-oncogene B | Q3TTA7 |
| Cblc | Cbl proto-oncogene C | Q80XL1 |
| Cdkn1a | cyclin-dependent kinase inhibitor 1 | P39689 |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | P46414 |
| Crk | CRK proto-oncogene, adaptor protein | Q64010 |
| Crkl | CRK like proto-oncogene, adaptor protein | P47941 |
| Egf | pro-epidermal growth factor | P01132 |
| Egfr | epidermal growth factor receptor | Q01279 |
| Eif4e | eukaryotic translation initiation factor 4E | P63073 |
| Eif4e1b | eukaryotic translation initiation factor 4E family member 1B | Q3UTA9 |
| Eif4e2 | eukaryotic translation initiation factor 4E family member 2 | Q8BMB3 |
| Eif4ebp1 | eukaryotic translation initiation factor 4E binding protein 1 | Q60876 |
| Elk1 | ELK1, ETS transcription factor | P41969 |
| Erbb2 | receptor tyrosine-protein kinase erbB-2 | P70424 |
| Erbb3 | receptor tyrosine-protein kinase erbB-3 | Q61526 |
| Erbb4 | receptor tyrosine-protein kinase erbB-4 | Q61527 |
| Ereg | proepiregulin preproprotein | Q61521 |
| Exoc7 | exocyst complex component 7 | O35250 |
| Fasn | fatty acid synthase | P19096 |
| Fbp1 | fructose-bisphosphatase 1 | Q9QXD6 |
| Fbp2 | fructose-bisphosphatase 2 | P70695 |
| Flot1 | flotillin 1 | O08917 |
| Flot2 | flotillin 2 | Q60634 |
| Foxo1 | forkhead box O1 | Q9R1E0 |
| G6pc | glucose-6-phosphatase catalytic subunit | P35576 |
| G6pc2 | glucose-6-phosphatase catalytic subunit 2 | Q9Z186 |
| G6pc3 | glucose-6-phosphatase catalytic subunit 3 | Q6NSQ9 |
| Gab1 | GRB2-associated-binding protein 1 | Q9QYY0 |
| Gck | glucokinase | P52792 |
| Grb2 | growth factor receptor bound protein 2 | Q60631 |
| Gsk3b | glycogen synthase kinase 3 beta | Q9WV60 |
| Gys1 | glycogen synthase 1 | Q9Z1E4 |
| Gys2 | glycogen synthase 2 | Q8VCB3 |
| Hbegf | proheparin-binding EGF-like growth factor | Q06186 |
| Hk1 | hexokinase 1 | P17710 |
| Hk2 | hexokinase 2 | O08528 |
| Hk3 | hexokinase 3 | Q3TRM8 |
| Hkdc1 | hexokinase domain containing 1 | Q91W97 |
| Hras | HRas proto-oncogene, GTPase | Q61411 |
| Ikbkb | inhibitor of nuclear factor kappa B kinase subunit beta | O88351 |
| Inpp5k | inositol polyphosphate-5-phosphatase K | Q8C5L6 |
| Inppl1 | inositol polyphosphate phosphatase like 1 | Q6P549 |
| Insr | insulin receptor | P15208 |
| Irs1 | insulin receptor substrate 1 | P35569 |
| Irs2 | insulin receptor substrate 2 | P81122 |
| Irs4 | insulin receptor substrate 4 | Q9Z0Y7 |
| Jun | transcription factor Jun | P05627 |
| Kras | KRAS proto-oncogene, GTPase | P32883 |
| Lipe | lipase E, hormone sensitive type | P54310 |
| Map2k1 | mitogen-activated protein kinase kinase 1 | P31938 |
| Map2k2 | mitogen-activated protein kinase kinase 2 | Q63932 |
| Map2k4 | dual specificity mitogen-activated protein kinase kinase 4 | P47809 |
| Map2k7 | dual specificity mitogen-activated protein kinase kinase 7 | Q8CE90 |
| Mapk1 | mitogen-activated protein kinase 1 | P63085 |
| Mapk10 | mitogen-activated protein kinase 10 | Q61831 |
| Mapk3 | mitogen-activated protein kinase 3 | Q63844 |
| Mapk8 | mitogen-activated protein kinase 8 | Q91Y86 |
| Mapk9 | mitogen-activated protein kinase 9 | Q9WTU6 |
| Mknk1 | MAP kinase interacting serine/threonine kinase 1 | O08605 |
| Mknk2 | MAP kinase interacting serine/threonine kinase 2 | Q8CDB0 |
| Mtor | mechanistic target of rapamycin | Q9JLN9 |
| Myc | myc proto-oncogene protein | P01108 |
| Nck1 | cytoplasmic protein NCK1 | Q99M51 |
| Nck2 | cytoplasmic protein NCK2 | O55033 |
| Nras | NRAS proto-oncogene, GTPase | P08556 |
| Nrg1 | pro-neuregulin-1, membrane-bound | B0YIS1 |
| Nrg2 | pro-neuregulin-2, membrane-bound | P56974 |
| Nrg3 | pro-neuregulin-3, membrane-bound | O35181 |
| Nrg4 | pro-neuregulin-4, membrane-bound | Q9WTX4 |
| Pak1 | serine/threonine-protein kinase PAK 1 | O88643 |
| Pak2 | serine/threonine-protein kinase PAK 2 | Q8CIN4 |
| Pak3 | serine/threonine-protein kinase PAK 3 | Q61036 |
| Pak4 | serine/threonine-protein kinase PAK 4 | Q8BTW9 |
| Pak5 | serine/threonine-protein kinase PAK 5 | Q8C015 |
| Pak6 | serine/threonine-protein kinase PAK 6 | Q3ULB5 |
| Pck1 | phosphoenolpyruvate carboxykinase 1 | Q9Z2V4 |
| Pck2 | phosphoenolpyruvate carboxykinase 2, mitochondrial | Q8BH04 |
| Pde3b | phosphodiesterase 3B | Q61409 |
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | Q9Z2A0 |
| Phka1 | phosphorylase kinase regulatory subunit alpha 1 | P18826 |
| Phka2 | phosphorylase kinase regulatory subunit alpha 2 | Q8BWJ3 |
| Phkb | phosphorylase kinase regulatory subunit beta | Q7TSH2 |
| Phkg1 | phosphorylase kinase catalytic subunit gamma 1 | P07934 |
| Phkg2 | phosphorylase kinase catalytic subunit gamma 2 | Q9DB30 |
| Pik3ca | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | P42337 |
| Pik3cb | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | Q8BTI9 |
| Pik3cd | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | O35904 |
| Pik3r1 | phosphoinositide-3-kinase regulatory subunit 1 | P26450 |
| Pik3r2 | phosphoinositide-3-kinase regulatory subunit 2 | O08908 |
| Pik3r3 | phosphoinositide-3-kinase regulatory subunit 3 | Q64143 |
| Pklr | pyruvate kinase, liver and RBC | P53657 |
| Plcg1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Q62077 |
| Plcg2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | Q8CIH5 |
| Ppargc1a | PPARG coactivator 1 alpha | O70343 |
| Ppp1ca | protein phosphatase 1 catalytic subunit alpha | P62137 |
| Ppp1cb | protein phosphatase 1 catalytic subunit beta | P62141 |
| Ppp1cc | protein phosphatase 1 catalytic subunit gamma | P63087 |
| Ppp1r3a | protein phosphatase 1 regulatory subunit 3A | Q99MR9 |
| Ppp1r3b | protein phosphatase 1 regulatory subunit 3B | Q8C767 |
| Ppp1r3c | protein phosphatase 1 regulatory subunit 3C | Q7TMB3 |
| Ppp1r3d | protein phosphatase 1 regulatory subunit 3D | Q6DK02 |
| Ppp1r3e | protein phosphatase 1 regulatory subunit 3E | Q8BRJ4 |
| Ppp1r3f | protein phosphatase 1 regulatory subunit 3F | Q9JIG4 |
| Prkaa1 | protein kinase AMP-activated catalytic subunit alpha 1 | Q5EG47 |
| Prkaa2 | protein kinase AMP-activated catalytic subunit alpha 2 | Q8BRK8 |
| Prkab1 | protein kinase AMP-activated non-catalytic subunit beta 1 | Q9R078 |
| Prkab2 | protein kinase AMP-activated non-catalytic subunit beta 2 | Q6PAM0 |
| Prkaca | protein kinase cAMP-activated catalytic subunit alpha | P05132 |
| Prkacb | protein kinase cAMP-activated catalytic subunit beta | P68181 |
| Prkag1 | protein kinase AMP-activated non-catalytic subunit gamma 1 | O54950 |
| Prkag2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | Q91WG5 |
| Prkag3 | protein kinase AMP-activated non-catalytic subunit gamma 3 | Q8BGM7 |
| Prkar1a | protein kinase cAMP-dependent type I regulatory subunit alpha | Q9DBC7 |
| Prkar1b | protein kinase cAMP-dependent type I regulatory subunit beta | P12849 |
| Prkar2a | protein kinase cAMP-dependent type II regulatory subunit alpha | P12367 |
| Prkar2b | protein kinase cAMP-dependent type II regulatory subunit beta | P31324 |
| Prkca | protein kinase C alpha type | P20444 |
| Prkcb | protein kinase C beta type | P68404 |
| Prkcg | protein kinase C gamma type | P63318 |
| Prkci | protein kinase C iota | Q62074 |
| Prkcz | protein kinase C zeta | Q02956 |
| Ptk2 | focal adhesion kinase 1 | P34152 |
| Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | P35821 |
| Ptprf | protein tyrosine phosphatase, receptor type F | A2A8L5 |
| Pygb | glycogen phosphorylase B | Q8CI94 |
| Pygl | glycogen phosphorylase L | Q9ET01 |
| Pygm | glycogen phosphorylase, muscle associated | Q9WUB3 |
| Raf1 | Raf-1 proto-oncogene, serine/threonine kinase | Q99N57 |
| Rapgef1 | Rap guanine nucleotide exchange factor 1 | Q13905 |
| Rheb | Ras homolog enriched in brain | Q921J2 |
| Rhoq | ras homolog family member Q | Q8R527 |
| Rps6 | ribosomal protein S6 | P62754 |
| Rps6kb1 | ribosomal protein S6 kinase B1 | Q8BSK8 |
| Rps6kb2 | ribosomal protein S6 kinase B2 | Q9Z1M4 |
| Rptor | regulatory associated protein of MTOR complex 1 | Q8K4Q0 |
| Sh2b2 | SH2B adaptor protein 2 | Q9JID9 |
| Shc1 | SHC adaptor protein 1 | P98083 |
| Shc2 | SHC adaptor protein 2 | Q8BMC3 |
| Shc3 | SHC adaptor protein 3 | Q61120 |
| Shc4 | SHC adaptor protein 4 | Q6S5L9 |
| Slc2a4 | solute carrier family 2 member 4 | P14142 |
| Socs1 | suppressor of cytokine signaling 1 | O35716 |
| Socs2 | suppressor of cytokine signaling 2 | O35717 |
| Socs3 | suppressor of cytokine signaling 3 | O35718 |
| Socs4 | suppressor of cytokine signaling 4 | Q91ZA6 |
| Sorbs1 | sorbin and SH3 domain containing 1 | Q62417 |
| Sos1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | Q62245 |
| Sos2 | SOS Ras/Rho guanine nucleotide exchange factor 2 | Q02384 |
| Src | proto-oncogene tyrosine-protein kinase Src | P05480 |
| Srebf1 | sterol regulatory element binding transcription factor 1 | Q9WTN3 |
| Stat5a | signal transducer and activator of transcription 5A | P42230 |
| Stat5b | signal transducer and activator of transcription 5B | P42232 |
| Tgfa | protransforming growth factor alpha | P48030 |
| Trip10 | thyroid hormone receptor interactor 10 | Q8CJ53 |
| Tsc1 | tuberous sclerosis 1 | Q9EP53 |
| Tsc2 | tuberous sclerosis 2 | Q61037 |
| Gene Symbol | Annotation | UniProt Number |
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