National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Mammalian Immediate Early Genes

A list of immediate early genes from Tullai JW, Schaffer ME, Mullenbrock S, Sholder G, Kasif S, Cooper GM. Immediate-early and delayed primary response genes are distinct in function and genomic architecture. J Biol Chem. 2007;282:23981-95. PMID: 17575275. Authors employed global expression profiling to analyze the temporal program of transcriptional alterations induced by growth factor stimulation of human T98G human glioblastoma cells cells.

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

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Gene Symbol Annotation UniProt Number
Atf3 cyclic AMP-dependent transcription factor ATF-3 Q60765.1
Bhlhe40 Class E basic helix-loop-helix protein 40 O35185.1
Ccl2 C-C motif chemokine ligand 2 P10148.1
Ccn1 cysteine rich angiogenic inducer 61  P18406.1
Ccn2 connective tissue growth factor P29268.3
Ccnl1 cyclin L1  Q52KE7.1
Cebpd CCAAT/enhancer-binding protein delta Q00322.2
Csrnp1 cysteine and serine rich nuclear protein 1 P59054.1
Cxcl3 C-X-C motif chemokine ligand 3 Q6W5C0.1
Dusp1 dual specificity phosphatase 1  P28563.1
Dusp5 dual specificity phosphatase 5 Q16690.2
Dusp6 dual specificity phosphatase 6 Q9DBB1.1
Egr1 early growth response 1 P08046.2
Egr3 early growth response 3 P43300.2
F3 coagulation factor III, tissue factor (F3), transcript variant 1 P20352.2
Flg Human profilaggrin mRNA P11088.1
Fos Fos proto-oncogene, AP-1 transcription factor subunit P01101.1
Fosb FosB proto-oncogene, AP-1 transcription factor subunit P13346.1
Gadd45b growth arrest and DNA damage inducible beta  P22339.1
Gbp1 guanylate binding protein 1 Q01514.1
Gem GTP binding protein overexpressed in skeletal muscle P55041.2
Hbegf heparin binding EGF like growth factor  Q06186.1
Ier3 immediate early response 3 P46694.2
Il6 interleukin 6  P08505.1
Jun Jun proto-oncogene, AP-1 transcription factor subunit P05627.3
Junb JunB proto-oncogene, AP-1 transcription factor subunit P09450.1
Klf10 Kruppel like factor 10  O89091.1
Klf6 Kruppel like factor 6 O08584.3
Klhl21 kelch like family member 21 Q3U410.1
Ldlr low density lipoprotein receptor  P35951.2
Mcl1 myeloid cell leukemia sequence 1 P97287.3
Nfkbia NFKB inhibitor alpha  Q9Z1E3.2
Nfkbiz NFKB inhibitor zeta  Q9EST8.1
Nr2c2 mitogen induced nuclear orphan receptor  P49117.1
Nr4a1 nuclear receptor subfamily 4 group A member 1 P12813.1
Nr4a2 nuclear receptor subfamily 4 group A member 2 Q06219.1
Plau plasminogen activator, urokinase  P06869.1
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 Q9JM54.1
Rcan1 regulator of calcineurin 1  Q9JHG6.2
Sgk1 serum/glucocorticoid regulated kinase 1 Q9WVC6.1
Slc2a3 solute carrier family 2 member 3 P32037.1
Srf serum response factor  Q9JM73.1
Tnfaip3 TNF alpha induced protein 3  Q60769.2
Trib1 tribbles pseudokinase 1 Q8K4K4.2
Tsc22d1 TSC22 domain family protein 1 P62500.2
Zfp36 ZFP36 ring finger protein  P22893.1

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Gene Symbol Annotation UniProt Number

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