Compendium of transcripts downregulated by deletion of protein kinase A (PMID: 28973931) using RNA-seq in mpkCCD cells.
Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.
| Gene Symbol | Protein Name | Log2 Ratio (KO/Ctrl) | UniProt Number |
| Aqp2 | aquaporin-2 | -6.41 | P56402 |
| Pde4b | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | -4.77 | Q6IQY6 |
| Gsdmc2 | gasdermin-C2 | -3.97 | Q2KHK6 |
| Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | -3.73 | P05132 |
| Zhx2 | zinc fingers and homeoboxes protein 2 | -3.70 | Q8C0C0 |
| Adh1 | alcohol dehydrogenase 1 | -3.10 | P00329 |
| Gsdmc4 | gasdermin-C4 | -2.25 | Q3TR54 |
| Tmprss4 | transmembrane protease serine 4 | -2.25 | Q8VCA5 |
| Cd55 | complement decay-accelerating factor, GPI-anchored preproprotein | -2.11 | Q61475 |
| Fcgbp | IgGFc-binding protein | -1.98 | E9Q0B5 |
| Prom1 | prominin-1 isoform s8 | -1.98 | O54990 |
| Inmt | indolethylamine N-methyltransferase | -1.92 | P40936 |
| Ros1 | proto-oncogene tyrosine-protein kinase ROS | -1.84 | Q78DX7 |
| Baiap2l2 | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 | -1.82 | Q80Y61 |
| AU021092 | UPF0764 protein C16orf89 homolog | -1.73 | Q3UST5 |
| Chst13 | carbohydrate sulfotransferase 13 | -1.69 | Q8NET6 |
| Ly6e | lymphocyte antigen 6E | -1.63 | Q64253 |
| Aldh3b2 | aldehyde dehydrogenase family 3 member B2 | -1.62 | E9Q3E1 |
| Epas1 | endothelial PAS domain-containing protein 1 | -1.55 | P97481 |
| Cyfip2 | cytoplasmic FMR1-interacting protein 2 | -1.53 | Q5SQX6 |
| Aqp5 | aquaporin-5 | -1.51 | Q9WTY4 |
| Mgat3 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | -1.49 | Q10470 |
| Sema4a | semaphorin-4A | -1.45 | Q62178 |
| Clic3 | chloride intracellular channel protein 3 | -1.41 | Q9D7P7 |
| Fry | protein furry homolog | -1.39 | E9Q8I9 |
| Sh2d4b | SH2 domain-containing protein 4B | -1.39 | A6X942 |
| Plpp3 | phospholipid phosphatase 3 | -1.38 | Q99JY8 |
| Mapre2 | microtubule-associated protein RP/EB family member 2 | -1.37 | Q8R001 |
| G6pc3 | glucose-6-phosphatase 3 | -1.37 | Q6NSQ9 |
| Upk1a | uroplakin-1a | -1.35 | Q9D132 |
| Eya2 | eyes absent homolog 2 | -1.35 | O08575 |
| Top1mt | DNA topoisomerase I, mitochondrial | -1.35 | Q8R4U6 |
| Hid1 | protein HID1 | -1.35 | Q8R1F6 |
| Gsta4 | glutathione S-transferase A4 | -1.30 | P24472 |
| Tmem45b | transmembrane protein 45B | -1.29 | Q8VCZ2 |
| Ipcef1 | interactor protein for cytohesin exchange factors 1 | -1.26 | Q5DU31 |
| Abcc3 | ATP-binding cassette sub-family C member 3 | -1.26 | B2RX12 |
| Akr1b3 | aldo-keto reductase family 1 member B1 | -1.22 | Q5U415 |
| Phyhipl | phytanoyl-CoA hydroxylase-interacting protein-like | -1.22 | Q8BGT8 |
| Rab15 | ras-related protein Rab-15 | -1.19 | Q8K386 |
| Muc4 | mucin-4 | -1.17 | Q8JZM8 |
| Timp3 | metalloproteinase inhibitor 3 | -1.15 | P39876 |
| Bcl2l14 | apoptosis facilitator Bcl-2-like protein 14 | -1.14 | Q9CPT0 |
| Tgm1 | protein-glutamine gamma-glutamyltransferase K | -1.14 | Q9JLF6 |
| Upk3b | uroplakin-3b | -1.11 | Q80YF6 |
| Bcat1 | branched-chain-amino-acid aminotransferase, cytosolic | -1.11 | P24288 |
| Dnm3 | dynamin-3 | -1.09 | Q8BZ98 |
| Slc4a11 | solute carrier family 4 member 11 | -1.08 | A2AJN7 |
| Mettl7a1 | methyltransferase-like protein 7A | -1.08 | Q8C6B0 |
| Gstt2 | glutathione S-transferase theta-2 | -1.08 | Q61133 |
| Tmem213 | transmembrane protein 213 | -1.08 | Q08EA8 |
| Dock5 | dedicator of cytokinesis protein 5 | -1.07 | B2RY04 |
| Crabp2 | cellular retinoic acid-binding protein 2 | -1.05 | P22935 |
| Eepd1 | endonuclease/exonuclease/phosphatase family domain-containing protein 1 | -1.04 | Q3TGW2 |
| Hs3st1 | heparan sulfate glucosamine 3-O-sulfotransferase 1 | -1.03 | O35310 |
| Gas1 | growth arrest-specific protein 1 | -1.03 | Q01721 |
| Clec2d | C-type lectin domain family 2 member D | -1.01 | Q91V08 |
| Kank4 | KN motif and ankyrin repeat domain-containing protein 4 | -1.01 | Q6P9J5 |
| Abcc4 | ATP-binding cassette sub-family C member 4 | -0.95 | E9Q236 |
| Napsa | napsin-A | -0.95 | O09043 |
| Lrrc26 | leucine-rich repeat-containing protein 26 | -0.94 | Q91W20 |
| Trim2 | tripartite motif-containing protein 2 | -0.93 | Q9ESN6 |
| Npr3 | atrial natriuretic peptide receptor 3 | -0.92 | P70180 |
| Nadk2 | NAD kinase 2, mitochondrial | -0.89 | Q8C5H8 |
| Tpd52l1 | tumor protein D53 | -0.88 | O54818 |
| Arhgdib | rho GDP-dissociation inhibitor 2 | -0.88 | Q61599 |
| Oxr1 | oxidation resistance protein 1 | -0.88 | Q4KMM3 |
| Lgals3 | galectin-3 | -0.88 | P16110 |
| Rai14 | ankycorbin | -0.87 | Q9EP71 |
| Ccser1 | serine-rich coiled-coil domain-containing protein 1 | -0.87 | Q8C0C4 |
| Tcn2 | transcobalamin-2 | -0.86 | O88968 |
| Osgin1 | oxidative stress-induced growth inhibitor 1 | -0.86 | Q8VC10 |
| Ghr | growth hormone receptor | -0.86 | P16882 |
| Tspan14 | tetraspanin-14 | -0.85 | Q8QZY6 |
| 9130008F23Rik | uncharacterized protein C6orf141 homolog | -0.85 | A0A6P5RBI2 |
| Fgf1 | fibroblast growth factor 1 | -0.85 | P61148 |
| Fam65a | protein FAM65A isoform X6 | -0.85 | Q68FE6 |
| Gadd45a | growth arrest and DNA damage-inducible protein GADD45 alpha | -0.83 | P48316 |
| Slc6a9 | sodium- and chloride-dependent glycine transporter 1 | -0.83 | P28571 |
| Runx1 | runt-related transcription factor 1 | -0.83 | Q03347 |
| Muc20 | mucin-20 isoform a | -0.80 | Q8BUE7 |
| Gstm2 | glutathione S-transferase Mu 2 | -0.79 | P15626 |
| Sat1 | diamine acetyltransferase 1 | -0.79 | P48026 |
| Arap1 | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 | -0.79 | Q4LDD4 |
| Klf5 | Krueppel-like factor 5 | -0.77 | Q9Z0Z7 |
| Slc46a1 | proton-coupled folate transporter | -0.75 | Q6PEM8 |
| Pabpc1 | polyadenylate-binding protein 1 | -0.75 | P29341 |
| Gstt3 | glutathione S-transferase theta-3 | -0.74 | Q99L20 |
| Bcar3 | breast cancer anti-estrogen resistance protein 3 homolog | -0.74 | Q9QZK2 |
| Foxk1 | forkhead box protein K1 | -0.73 | P42128 |
| Sned1 | sushi, nidogen and EGF-like domain-containing protein 1 | -0.72 | Q70E20 |
| Slc25a37 | mitoferrin-1 | -0.71 | Q920G8 |
| Bid | BH3-interacting domain death agonist | -0.71 | P70444 |
| Laptm4b | lysosomal-associated transmembrane protein 4B | -0.71 | Q91XQ6 |
| Cldn8 | claudin-8 | -0.71 | Q9Z260 |
| Asns | asparagine synthetase [glutamine-hydrolyzing] | -0.70 | Q61024 |
| Scmh1 | polycomb protein SCMH1 | -0.70 | Q8K214 |
| Dap | death-associated protein 1 | -0.70 | Q91XC8 |
| Spry2 | protein sprouty homolog 2 | -0.70 | Q9QXV8 |
| Mgat4a | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | -0.68 | Q812G0 |
| Tars | threonine--tRNA ligase 1, cytoplasmic | -0.68 | Q9D0R2 |
| Capg | macrophage-capping protein | -0.66 | P24452 |
| Dcaf11 | DDB1- and CUL4-associated factor 11 | -0.66 | Q91VU6 |
| Dhrs4 | dehydrogenase/reductase SDR family member 4 | -0.66 | Q99LB2 |
| Cbr2 | carbonyl reductase [NADPH] 2 | -0.65 | P08074 |
| Slc37a1 | glucose-6-phosphate exchanger SLC37A1 | -0.65 | Q8R070 |
| Pck2 | phosphoenolpyruvate carboxykinase [GTP], mitochondrial | -0.65 | Q8BH04 |
| H6pd | GDH/6PGL endoplasmic bifunctional protein | -0.65 | Q8R1C3 |
| Vopp1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.65 | O89051 |
| Itm2b | integral membrane protein 2B | -0.63 | Q8BH06 |
| Il17re | interleukin-17 receptor E | -0.63 | Q9Z329 |
| Itpr2 | inositol 1,4,5-trisphosphate receptor type 2 | -0.63 | P35456 |
| Plaur | urokinase plasminogen activator surface receptor | -0.62 | Q8R3R8 |
| Gabarapl1 | gamma-aminobutyric acid receptor-associated protein-like 1 | -0.61 | Q9DBB1 |
| Dusp6 | dual specificity protein phosphatase 6 | -0.60 | Q8C7B8 |
| Zswim4 | zinc finger SWIM domain-containing protein 4 | -0.59 | Q6J9G1 |
| Styk1 | tyrosine-protein kinase STYK1 | -0.58 | Q8K4L3 |
| Svil | supervillin | -0.58 | Q8BJZ3 |
| Tmbim1 | protein lifeguard 3 | -0.57 | O88554 |
| Rpph1 | ribonuclease P RNA component H1 | -0.56 | Q9D823 |
| Rpl37 | 60S ribosomal protein L37 | -0.56 | Q9CQH0 |
| Pdzk1ip1 | PDZK1-interacting protein 1 | -0.55 | Q8K0Q5 |
| Arhgap18 | rho GTPase-activating protein 18 | -0.55 | Q9EST8 |
| Nfkbiz | NF-kappa-B inhibitor zeta | -0.55 | Q9QXS1 |
| Plec | plectin | -0.55 | O35375 |
| Nrp2 | neuropilin-2 | -0.54 | Q8BYZ7 |
| Elmo3 | engulfment and cell motility protein 3 | -0.53 | Q91XA2 |
| Golm1 | Golgi membrane protein 1 | -0.51 | Q80TP3 |
| Ubr5 | E3 ubiquitin-protein ligase UBR5 | -0.46 | Q3URS9 |
| Gene Symbol | Protein Name | Log2 Ratio (KO/Ctrl) | UniProt Number |
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