National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


Wnt/Frizzled Target Genes (Mammalian)

Gene list is based on an investigator-curated website, Nusse Laboratory at Stanford, listing target genes of Wnt/beta-catenin signaling in multiple species. All proteins have been indexed to mouse gene symbols.

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

To search, use browser's Find command (Ctrl-F)

Gene symbol Annotation UniProt No.
Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B P06795.1
Atoh1 atonal bHLH transcription factor 1 P48985.1
Axin2 axin-2 O88566.2
Bglap2 bone gamma-carboxyglutamate protein 2 P86547.1
Birc5 baculoviral IAP repeat-containing 5 O70201.1
Bmp4 bone morphogenetic protein 4 preproprotein P21275.2
Btrc F-box/WD repeat-containing protein 1A isoform X4 Q3ULA2.2
Cacna1g voltage-dependent T-type calcium channel subunit alpha-1G O43497.3
Ccna2 cyclin A2 P51943.2
Ccnd1 G1/S-specific cyclin-D1 isoform X2 P25322.1
Cd44 CD44 antigen isoform f precursor P15379.3
Cdh1 cadherin-1 P09803.1
Cdkn2a cyclin-dependent kinase inhibitor 2A P51480.2
Cdx1 homeobox protein CDX-1 P18111.2
Cdx4 homeobox protein CDX-4 Q07424.1
Cldn1 claudin-1 O88551.1
Cox2 cytochrome c oxidase subunit II (mitochondrion) P00405.1
Ctla4 cytotoxic T-lymphocyte protein 4 isoform X2 P09793.1
Cyr61 protein CYR61 precursor P18406.1
Dkk1 dickkopf WNT signaling pathway inhibitor 1 O54908.2
Dll1 delta-like protein 1 Q61483.2
Dspp dentin sialophosphoprotein P97399.2
Eda ectodysplasin-A isoform 8 O54693.2
Edn1 endothelin 1 P22387.3
Egfr epidermal growth factor receptor isoform 1 precursor Q01279.1
En1 engrailed 1 P09065.3
En2 engrailed 2 P09066.2
Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 4 Q9R1E6.3
Ephb1 ephrin type-B receptor 1 isoform 2 precursor Q8CBF3.1
Fgf18 fibroblast growth factor 18 O89101.1
Fgf20 fibroblast growth factor 20 Q9ESL9.2
Fgf4 fibroblast growth factor 4 precursor P11403.2
Fgf9 fibroblast growth factor 9 precursor P54130.2
Fn1 fibronectin 1 P11276.4
Fosl1 fos-related antigen 1 isoform X6 P48755.2
Foxn1 forkhead box protein N1 isoform X3 Q61575.1
Fst follistatin P47931.1
Fzd2 frizzled-2 Q9JIP6.1
Fzd7 frizzled-7 Q61090.2
Gast gastrin P48757.2
Gbx2 homeobox protein GBX-2 P48031.1
Gcg glucagon P55095.1
Gja1 gap junction alpha-1 protein P23242.2
Gjb6 gap junction beta-6 protein P70689.1
Grem1 gremlin-1 isoform X3 O70326.1
Hnf1a hepatocyte nuclear factor 1-alpha P22361.2
Id2 DNA-binding protein inhibitor ID-2 P41136.3
Igf1 insulin-like growth factor 1  P05017.2
Igf2 insulin-like growth factor 2 P09535.1
Ikbkg inhibitor of kappaB kinase gamma O88522.2
Il6 interleukin 6 P08505.1
Il8 interleukin 8 Q9WVL7.1
Irx3 iroquois-class homeodomain protein IRX-3 isoform 1 P81067.2
Isl1 ISL1 transcription factor, LIM/homeodomain P61372.1
Jag1 jagged 1 Q9QXX0.1
Jag1 protein jagged-1 precursor Q9QXX0.1
Jun transcription factor AP-1 P05627.3
Klf5 Kruppel-like factor 5 Q9Z0Z7.2
L1cam neural cell adhesion molecule L1 isoform X4 P11627.1
Lbh protein LBH Q9CX60.1
Lef1 lymphoid enhancer-binding factor 1 isoform X6 P27782.1
Lgr5 leucine-rich repeat-containing G-protein coupled receptor 5 Q9Z1P4.2
Maea macrophage erythroblast attacher Q4VC33.1
Met hepatocyte growth factor receptor isoform X2 P16056.1
Mitf microphthalmia-associated transcription factor Q08874.4
Mmp2 72 kDa type IV collagenase P33434.1
Mmp26 matrix metalloproteinase-26 Q9NRE1.2
Mmp3 matrix metallopeptidase 3 P28862.2
Mmp7 matrilysin isoform X2 Q10738.1
Mmp9 matrix metalloproteinase-9 isoform X2 P41245.2
Msl1 male-specific lethal 1 homolog isoform X3 Q6PDM1.1
Myc myc proto-oncogene protein isoform b P01108.1
Mycbp C-Myc-binding protein Q9EQS3.5
Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived P03966.2
Myf5 myogenic factor 5 P24699.1
Myf6 myogenic factor 6 P15375.1
Myod1 myogenic differentiation 1 P10085.2
Myog myogenin P12979.2
Nanog homeobox protein NANOG Q5TM83.1
Neurod1 neurogenic differentiation factor 1 Q60867.2
Neurog1 neurogenin-1 P70660.1
Nkx2-2 NK2 homeobox 2 P42586.2
Nos2 nitric oxide synthase P29477.1
Nrcam neuronal cell adhesion molecule Q810U4.2
Ovol1 ovo like zinc finger 1 Q9WTJ2.1
Pitx2 paired-like homeodomain transcription factor 2 P97474.2
Plaur plasminogen activator, urokinase receptor P35456.1
Postn periostin, osteoblast specific factor Q62009.2
Pou5f1 POU domain P20263.1
Ppard peroxisome proliferator activator receptor delta P35396.1
Prl2c3 prolactin family 2, subfamily c, member 3 P04768.2
Ptgs2 prostaglandin G/H synthase 2 Q05769.1
Pttg1 securin isoform X2 Q9CQJ7.1
Rarg retinoic acid receptor gamma P18911.3
Rasgrf1 ras-specific guanine nucleotide-releasing factor 1 P27671.2
Ret proto-oncogene tyrosine-protein kinase receptor Ret P35546.2
Rhou rho-related GTP-binding protein RhoU Q9EQT3.1
Runx2 runt-related transcription factor 2 isoform X5 Q08775.2
Sall4 sal-like protein 4 isoform X5 Q8BX22.2
Sfrp2 secreted frizzled related protein 2 P97299.2
Six3 homeobox protein SIX3 Q62233.2
Snai1 snail family zinc finger 1 Q02085.1
Sox17 transcription factor SOX-17 isoform X2 Q61473.1
Sox2 transcription factor SOX-2 P48432.2
Sox9 transcription factor SOX-9 Q04887.2
Sp5 transcription factor Sp5 Q9JHX2.1
Stra6 stimulated by retinoic acid gene 6 protein O70491.1
Tbx1 T-box transcription factor TBX1 isoform X3 P70323.2
Tbx3 T-box transcription factor TBX3 isoform X2 P70324.3
Tcf4 transcription factor 4 Q60722.1
Tert telomerase reverse transcriptase O70372.1
Tiam1 T-lymphoma invasion and metastasis-inducing protein 1 Q60610.1
Tnfrsf11a tumor necrosis factor receptor superfamily member 11A O35305.1
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) O08712.1
Tnfrsf19 tumor necrosis factor receptor superfamily member 19 precursor Q9JLL3.2
Tnfrsf9 tumor necrosis factor receptor superfamily member 9 isoform X2 P20334.1
Twist1 wist basic helix-loop-helix transcription factor 1 P26687.1
Ubxn1 UBX domain protein 1 Q922Y1.1
Vcan versican Q62059.2
Vegfa vascular endothelial growth factor A Q00731.2
Vegfc vascular endothelial growth factor C P97953.1
Wisp1 WNT1-inducible-signaling pathway protein 1 precursor O54775.1
Wisp2 WNT1-inducible-signaling pathway protein 2 precursor O76076.1
Wnt3a protein Wnt-3a P27467.1

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Gene symbol Annotation UniProt No.