Proteins that determine cAMP levels in cells. Converted to mouse gene symbols. From: Mehta et al. "ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells. Kidney Int. 2022; 101: 47-62. PMID: 34757121.
Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.
| Gene Symbol | Molecular Function | Annotation | Uniprot Number |
| Abcc4 | cAMP efflux transporter | ATP-binding cassette sub-family C member 4 | E9Q236 |
| Abcc5 | cAMP efflux transporter | ATP-binding cassette sub-family C member 5 | Q9R1X5 |
| Adcy1 | Produces cAMP | adenylate cyclase type 1 | O88444 |
| Adcy2 | Produces cAMP | adenylate cyclase type 2 | Q80TL1 |
| Adcy3 | Produces cAMP | adenylate cyclase type 3 | Q8VHH7 |
| Adcy4 | Produces cAMP | adenylate cyclase type 4 | Q91WF3 |
| Adcy5 | Produces cAMP | adenylate cyclase type 5 | P84309 |
| Adcy6 | Produces cAMP | adenylate cyclase type 6 | Q01341 |
| Adcy7 | Produces cAMP | adenylate cyclase type 7 | P51829 |
| Adcy8 | Produces cAMP | adenylate cyclase type 8 | P97490 |
| Adcy9 | Produces cAMP | adenylate cyclase type 9 | P51830 |
| Adcy10 | Produces cAMP | adenylate cyclase type 10 | Q8C0T9 |
| Pde1a | Degrades cAMP | dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Q61481 |
| Pde1b | Degrades cAMP | dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Q01065 |
| Pde1c | Degrades cAMP | dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Q64338 |
| Pde2a | Degrades cAMP | cGMP-dependent 3',5'-cyclic phosphodiesterase | Q922S4 |
| Pde3a | Degrades cAMP | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Q9Z0X4 |
| Pde3b | Degrades cAMP | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Q61409 |
| Pde4a | Degrades cAMP | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | O89084 |
| Pde4b | Degrades cAMP | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Q8VBU5 |
| Pde4c | Degrades cAMP | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Q3UEI1 |
| Pde4d | Degrades cAMP | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Q01063 |
| Pde7a | Degrades cAMP | high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | P70453 |
| Pde7b | Degrades cAMP | cAMP-specific 3',5'-cyclic phosphodiesterase 7B | Q9QXQ1 |
| Pde8a | Degrades cAMP | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | O88502 |
| Pde8b | Degrades cAMP | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B | E9Q4S1 |
| Pde10a | Degrades cAMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Q8CA95 |
| Pde11a | Degrades cAMP | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | P0C1Q2 |
| Gene Symbol | Molecular Function | Annotation | Uniprot Number |
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