p53 regulated genes curated by M. Fisher (Fischer M. Census and evaluation of p53 target genes. Oncogene. 2017; 36: 3943-3956. PMID: 28288132). All genes have been converted to mouse.
Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.
Gene Symbol | Protein Name | UniProt Number |
Abca12 | glucosylceramide transporter ABCA12 | E9Q876 |
Abcc1 | multidrug resistance protein 1 | O35379 |
Acad11 | acyl-CoA dehydrogenase family member 11 | Q80XL6 |
Acta2 | actin, aortic smooth muscle | P62737 |
Aen | apoptosis-enhancing nuclease | Q9CZI9 |
Afp | alpha-fetoprotein | P02772 |
Agt | angiotensinogen | P11859 |
Agtr1a | type-1 angiotensin II receptor | P29754 |
Aifm1 | apoptosis-inducing factor 1, mitochondrial | Q9Z0X1 |
Aifm2 | ferroptosis suppressor protein 1 | Q8BUE4 |
Alox5 | polyunsaturated fatty acid 5-lipoxygenase | P48999 |
Anln | anillin | Q8K298 |
Anxa1 | annexin A1 | P10107 |
Apaf1 | apoptotic protease-activating factor 1 | O88879 |
Apc | adenomatous polyposis coli protein | Q61315 |
Apex1 | DNA-(apurinic or apyrimidinic site) endonuclease | P28352 |
Apob | apolipoprotein B-100 | E9Q414 |
Apobec1 | C->U-editing enzyme APOBEC-1 | P51908 |
Ar | androgen receptor | P19091 |
Arid3a | AT-rich interactive domain-containing protein 3A | Q62431 |
Arnt2 | aryl hydrocarbon receptor nuclear translocator 2 | Q61324 |
Atf3 | cyclic AMP-dependent transcription factor ATF-3 | Q60765 |
Atr | serine/threonine-protein kinase ATR | Q9JKK8 |
Bak1 | bcl-2 homologous antagonist/killer | O08734 |
Banp | protein BANP | Q8VBU8 |
Bax | apoptosis regulator BAX | Q07813 |
Bbc3 | bcl-2-binding component 3 | Q99ML1 |
Bcl2 | apoptosis regulator Bcl-2 | P10417 |
Bcl2l14 | apoptosis facilitator Bcl-2-like protein 14 | Q9CPT0 |
Bcl6 | B-cell lymphoma 6 protein homolog | P41183 |
Bdkrb2 | B2 bradykinin receptor | P32299 |
Bhlhe40 | class E basic helix-loop-helix protein 40 | O35185 |
Bid | BH3-interacting domain death agonist | P70444 |
Birc5 | baculoviral IAP repeat-containing protein 5 | O70201 |
Bnip3 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | O55003 |
Bnip3l | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | Q9Z2F7 |
Brca2 | breast cancer type 2 susceptibility protein homolog | P97929 |
Btg2 | protein BTG2 | Q04211 |
Btg3 | protein BTG3 | P50615 |
Casp1 | caspase-1 | P29452 |
Casp6 | caspase-6 | O08738 |
Cav1 | caveolin-1 | P49817 |
Cbg | corticosteroid-binding globulin | Q06770 |
Cbl | E3 ubiquitin-protein ligase CBL | P22682 |
Ccn3 | CCN family member 3 | Q64299 |
Ccnb1 | G2/mitotic-specific cyclin-B1 | P24860 |
Ccnb2 | G2/mitotic-specific cyclin-B2 | P30276 |
Ccng1 | cyclin-G1 | P51945 |
Ccnk | cyclin-K | O88874 |
Cd44 | CD44 antigen | P15379 |
Cd82 | CD82 antigen | P40237 |
Cdc20 | cell division cycle protein 20 homolog | Q9JJ66 |
Cdc25b | M-phase inducer phosphatase 2 | P30306 |
Cdc25c | M-phase inducer phosphatase 3 | P48967 |
Cdip1 | cell death-inducing p53-target protein 1 | Q9DB75 |
Cdk1 | cyclin-dependent kinase 1 | P11440 |
Cdkn1a | cyclin-dependent kinase inhibitor 1 | P39689 |
Cdkn2a | cyclin-dependent kinase inhibitor 2A p16INK4a | P51480 |
Cel | bile salt-activated lipase | Q64285 |
Cers6 | ceramide synthase 6 | Q8C172 |
Ces2 | cocaine esterase | Q91WG0 |
Chek1 | serine/threonine-protein kinase Chk1 | O35280 |
Chmp4c | charged multivesicular body protein 4c | Q9D7F7 |
Ckm | creatine kinase M-type | P07310 |
Cks2 | cyclin-dependent kinases regulatory subunit 2 | P56390 |
Col18a1 | collagen alpha-1(XVIII) chain | P39061 |
Comt | catechol O-methyltransferase | O88587 |
Cpt1c | carnitine O-palmitoyltransferase 1, brain isoform | Q8BGD5 |
Cryz | quinone oxidoreductase | P47199 |
Csf1 | macrophage colony-stimulating factor 1 | P07141 |
Cst3 | cystatin-C | P21460 |
Ctf1 | cardiotrophin-1 | Q60753 |
Ctsd | cathepsin D | P18242 |
Cx3cl1 | fractalkine | O35188 |
Cyfip2 | cytoplasmic FMR1-interacting protein 2 | Q5SQX6 |
Cyp21 | steroid 21-hydroxylase | P03940 |
Dapk1 | death-associated protein kinase 1 | Q80YE7 |
Ddb2 | DNA damage-binding protein 2 | Q99J79 |
Ddr1 | epithelial discoidin domain-containing receptor 1 | Q03146 |
Def6 | differentially expressed in FDCP 6 | Q8C2K1 |
Dgkz | diacylglycerol kinase zeta | Q80UP3 |
Dhrs3 | short-chain dehydrogenase/reductase 3 | O88876 |
Dkk1 | dickkopf-related protein 1 | O54908 |
Dnmt1 | DNA (cytosine-5)-methyltransferase 1 | P13864 |
Dram1 | DNA damage-regulated autophagy modulator protein 1 | Q9DC58 |
Dsp | desmoplakin | E9Q557 |
Dusp1 | dual specificity protein phosphatase 1 | P28563 |
Dusp2 | dual specificity protein phosphatase 2 | Q05922 |
Dusp4 | dual specificity protein phosphatase 4 | Q8BFV3 |
Dusp5 | dual specificity protein phosphatase 5 | Q1HL35 |
Dusp6 | dual specificity protein phosphatase 6 | Q9DBB1 |
Dut | deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | Q9CQ43 |
E2f7 | transcription factor E2F7 | Q6S7F2 |
Ect2 | protein ECT2 | Q07139 |
Eda2r | tumor necrosis factor receptor superfamily member 27 | Q8BX35 |
Edn2 | endothelin-2 preproprotein | P22389 |
Egfr | epidermal growth factor receptor | Q01279 |
Egr2 | E3 SUMO-protein ligase EGR2 | P08152 |
Epcam | epithelial cell adhesion molecule | Q99JW5 |
Epha2 | ephrin type-A receptor 2 | Q03145 |
Erap1 | endoplasmic reticulum aminopeptidase 1 | Q9EQH2 |
Ercc1 | DNA excision repair protein ERCC-1 | P07903 |
Esr1 | estrogen receptor | P19785 |
F2r | proteinase-activated receptor 1 | P30558 |
Fancc | Fanconi anemia group C protein homolog | P50652 |
Fas | tumor necrosis factor receptor superfamily member 6 | P25446 |
Fbxo22 | F-box only protein 22 | Q78JE5 |
Fdft1 | squalene synthase | P53798 |
Fdps | farnesyl pyrophosphate synthase | Q920E5 |
Fdxr | NADPH:adrenodoxin oxidoreductase, mitochondrial | Q61578 |
Flt1 | vascular endothelial growth factor receptor 1 | P35969 |
Fos | protein c-Fos | P01101 |
Foxf1 | forkhead box protein F1 | Q61080 |
Foxp3 | forkhead box protein P3 | Q99JB6 |
Fuca1 | tissue alpha-L-fucosidase | Q99LJ1 |
Fzd2 | frizzled-2 | Q9JIP6 |
Gad2 | glutamate decarboxylase 2 | P48320 |
Gadd45a | growth arrest and DNA damage-inducible protein GADD45 alpha | P48316 |
Gamt | guanidinoacetate N-methyltransferase | O35969 |
Gbp1 | guanylate-binding protein 1 | Q01514 |
Gch1 | GTP cyclohydrolase 1 | Q05915 |
Gdf15 | growth/differentiation factor 15 preproprotein | Q9Z0J7 |
Gdf9 | growth/differentiation factor 9 | Q07105 |
Gfi1 | zinc finger protein Gfi-1 | P70338 |
Gls2 | glutaminase liver isoform, mitochondrial | Q571F8 |
Gpr87 | G-protein coupled receptor 87 | Q99MT7 |
Gpx1 | glutathione peroxidase 1 | P11352 |
Gstp1 | glutathione S-transferase P 1 | P19157 |
Hamp | hepcidin preproprotein | Q9EQ21 |
Hdc | histidine decarboxylase | P23738 |
Hic1 | hypermethylated in cancer 1 protein | Q9R1Y5 |
Hmgcll1 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic | Q8JZS7 |
Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Q01237 |
Hnf4a | hepatocyte nuclear factor 4-alpha isoform HNF4alpha10 | P49698 |
Hpse | heparanase preproprotein | Q6YGZ1 |
Hras | GTPase HRas | Q61411 |
Hsp90ab1 | heat shock protein HSP 90-beta | P11499 |
Hspa8 | heat shock cognate 71 kDa protein | P63017 |
Htt | huntingtin | P42859 |
Id2 | DNA-binding protein inhibitor ID-2 | P41136 |
Ier3 | radiation-inducible immediate-early gene IEX-1 | P46694 |
Ier5 | immediate early response gene 5 protein | O89113 |
Igf1r | insulin-like growth factor 1 receptor | Q60751 |
Igfbp3 | insulin-like growth factor-binding protein 3 | P47878 |
Irf2bp2 | interferon regulatory factor 2-binding protein 2 | E9Q1P8 |
Irf5 | interferon regulatory factor 5 | P56477 |
Irf9 | interferon regulatory factor 9 | Q61179 |
Iscu | iron-sulfur cluster assembly enzyme ISCU, mitochondrial | Q9D7P6 |
Kiaa0513 | uncharacterized protein KIAA0513 homolog | Q8R0A7 |
Kitlg | kit ligand | P20826 |
Krt14 | keratin, type I cytoskeletal 14 | Q61781 |
Krt8 | keratin, type II cytoskeletal 8 | P11679 |
Larp1 | la-related protein 1 | Q6ZQ58 |
Lasp1 | LIM and SH3 domain protein 1 | Q61792 |
Ldlr | low-density lipoprotein receptor presursor | P35951 |
Lgals3 | galectin-3 | P16110 |
Lif | leukemia inhibitory factor | P09056 |
Limk2 | LIM domain kinase 2 | O54785 |
Lmna | prelamin-A/C | P48678 |
Lonp1 | lon protease homolog, mitochondrial | Q8CGK3 |
Lpin1 | phosphatidate phosphatase LPIN1 | Q91ZP3 |
Mad1l1 | mitotic spindle assembly checkpoint protein MAD1 | Q9WTX8 |
Map4 | microtubule-associated protein 4 | P27546 |
Map4k4 | mitogen-activated protein kinase kinase kinase kinase 4 | P97820 |
Mapk8 | mitogen-activated protein kinase 8 | Q91Y86 |
Mb | myoglobin | P04247 |
Mdm2 | E3 ubiquitin-protein ligase Mdm2 | P23804 |
Me1 | NADP-dependent malic enzyme | P06801 |
Me2 | NAD-dependent malic enzyme, mitochondrial | Q99KE1 |
Me3 | NADP-dependent malic enzyme, mitochondrial | Q8BMF3 |
Met | hepatocyte growth factor receptor | P16056 |
Mfn2 | mitofusin-2 | Q80U63 |
Mlh1 | DNA mismatch repair protein Mlh1 | Q9JK91 |
Mmp2 | 72 kDa type IV collagenase preproprotein | P33434 |
Mpzl2 | myelin protein zero-like protein 2 | O70255 |
Msh2 | DNA mismatch repair protein Msh2 | P43247 |
Mta1 | metastasis-associated protein MTA1 | Q8K4B0 |
Mvk | mevalonate kinase | Q9R008 |
Myc | myc proto-oncogene protein | P01108 |
Myog | myogenin | P12979 |
Nanog | homeobox protein NANOG | Q5TM83 |
Ncf2 | neutrophil cytosol factor 2 | O70145 |
Ndrg1 | protein NDRG1 | Q62433 |
Nek2 | serine/threonine-protein kinase Nek2 | O35942 |
Ninj1 | ninjurin-1 | O70131 |
Nlrc4 | NLR family CARD domain-containing protein 4 | Q3UP24 |
Nol3 | nucleolar protein 3 | Q9D1X0 |
Nos3 | nitric oxide synthase, endothelial | P70313 |
Notch1 | neurogenic locus notch homolog protein 1 | Q01705 |
Nr0b2 | nuclear receptor subfamily 0 group B member 2 | Q62227 |
Nsg1 | neuronal vesicle trafficking-associated protein 1 | Q62092 |
Odc1 | ornithine decarboxylase | P00860 |
Ogn | mimecan | Q62000 |
Orm2 | alpha-1-acid glycoprotein 2 | P07361 |
Padi4 | protein-arginine deiminase type-4 | Q9Z183 |
Pank1 | pantothenate kinase 1 | Q8K4K6 |
Pank2 | pantothenate kinase 2, mitochondrial | Q7M753 |
Pax2 | paired box protein Pax-2 | P32114 |
Pcbp4 | poly(rC)-binding protein 4 | P57724 |
Pcdh10 | protocadherin-10 | Q6P0A6 |
Pcna | proliferating cell nuclear antigen | P17918 |
Pebp1 | phosphatidylethanolamine-binding protein 1 | P70296 |
Perp | p53 apoptosis effector related to PMP-22 | Q9JK95 |
Pgf | placenta growth factor | P49764 |
Phf1 | PHD finger protein 1 | Q9Z1B8 |
Phlda3 | pleckstrin homology-like domain family A member 3 | Q9WV95 |
Pidd1 | p53-induced death domain-containing protein 1 | Q9ERV7 |
Pik3ca | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha | P42337 |
Pkd1 | polycystin-1 | O08852 |
Plagl1 | zinc finger protein PLAGL1 | O35745 |
Plk1 | serine/threonine-protein kinase PLK1 | Q07832 |
Plk2 | serine/threonine-protein kinase PLK2 | P53351 |
Plk3 | serine/threonine-protein kinase PLK3 | Q60806 |
Pltp | phospholipid transfer protein | P55065 |
Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 | Q9JM54 |
Pml | protein PML | Q60953 |
Pms2 | mismatch repair endonuclease PMS2 | P54279 |
Pold1 | DNA polymerase delta catalytic subunit | P52431 |
Polh | DNA polymerase eta | Q9JJN0 |
Pomc | pro-opiomelanocortin preproprotein | P01193 |
Ppargc1a | peroxisome proliferator-activated receptor gamma coactivator 1-alpha | O70343 |
Ppargc1b | peroxisome proliferator-activated receptor gamma coactivator 1-beta | Q8VHJ7 |
Ppm1d | protein phosphatase 1D | Q9QZ67 |
Ppm1j | protein phosphatase 1J | Q149T7 |
Prap1 | proline-rich acidic protein 1 | Q80XD8 |
Prc1 | protein regulator of cytokinesis 1 | Q99K43 |
Prdm1 | PR domain zinc finger protein 1 | Q60636 |
Prkab1 | 5'-AMP-activated protein kinase subunit beta-1 | Q9R078 |
Prodh | proline dehydrogenase 1, mitochondrial | Q9WU79 |
Prom1 | prominin-1 | O54990 |
Psrc1 | proline/serine-rich coiled-coil protein 1 | Q9D0P7 |
Ptchd4 | patched domain-containing protein 4 | B9EKX1 |
Pten | PI- 3,4,5-P 3-phosphatase and dual-specificity protein phosphatase | O08586 |
Ptgs2 | prostaglandin G/H synthase 2 | Q05769 |
Ptk2 | focal adhesion kinase 1 | P34152 |
Ptp4a1 | protein tyrosine phosphatase type IVA 1 | Q63739 |
Ptpn6 | tyrosine-protein phosphatase non-receptor type 6 | P29351 |
Ptprv | receptor-type tyrosine-protein phosphatase V | P70289 |
Pttg1 | securin | Q9CQJ7 |
Pycard | apoptosis-associated speck-like protein containing a CARD | Q9EPB4 |
Rab6a | ras-related protein Rab-6A | P35279 |
Rabggta | geranylgeranyl transferase type-2 subunit alpha | Q9JHK4 |
Rad17 | cell cycle checkpoint protein RAD17 | Q6NXW6 |
Rad23a | UV excision repair protein RAD23 homolog A | P54726 |
Rad51 | DNA repair protein RAD51 homolog 1 | Q08297 |
Rap2b | ras-related protein Rap-2b | P61226 |
Rara | retinoic acid receptor alpha | P11416 |
Rarres2 | retinoic acid receptor responder protein 2 | Q9DD06 |
Rb1 | retinoblastoma-associated protein | P13405 |
Rbm38 | RNA-binding protein 38 | Q62176 |
Rbpj | recombining binding protein suppressor of hairless | P31266 |
Rchy1 | RING finger and CHY zinc finger domain-containing protein 1 | Q9CR50 |
Recql4 | ATP-dependent DNA helicase Q4 | Q75NR7 |
Rfc4 | replication factor C subunit 4 | Q99J62 |
Rgcc | regulator of cell cycle RGCC | Q9DBX1 |
Rhoc | rho-related GTP-binding protein RhoC | Q62159 |
Rnd3 | rho-related GTP-binding protein RhoE | P61588 |
Rnf144b | E3 ubiquitin-protein ligase RNF144B | Q8BKD6 |
Rps27l | 40S ribosomal protein S27-like | Q6ZWY3 |
Rrad | GTP-binding protein RAD | O88667 |
Rrm2b | ribonucleoside-diphosphate reductase subunit M2 B | Q6PEE3 |
Rtn4 | reticulon-4 | Q99P72 |
S100a2 | S100 calcium binding protein A2 | J3QMC7 |
S100a9 | protein S100-A9 | P31725 |
Sall2 | sal-like protein 2 | Q9QX96 |
Scd1 | Acyl-CoA desaturase 1 | P13516 |
Scn3b | sodium channel subunit beta-3 | Q8BHK2 |
Sema3b | semaphorin-3B | Q62177 |
Sema3f | semaphorin-3F | O88632 |
Serpina6 | corticosteroid-binding globulin | Q06770 |
Serpinb5 | serpin B5 | P70124 |
Serpine1 | plasminogen activator inhibitor 1 | P22777 |
Sesn1 | sestrin-1 | P58006 |
Sgk1 | serine/threonine-protein kinase Sgk1 | Q9WVC6 |
Sh2d1a | SH2 domain-containing protein 1A | O88890 |
Shbg | sex hormone-binding globulin | P97497 |
Siah1 | E3 ubiquitin-protein ligase SIAH1 | P61092 |
Siva1 | apoptosis regulatory protein Siva | O54926 |
Slc2a4 | solute carrier family 2, facilitated glucose transporter member 4 | P14142 |
Slc38a2 | sodium-coupled neutral amino acid transporter 2 | Q8CFE6 |
Slc6a6 | sodium- and chloride-dependent taurine transporter | O35316 |
Slc7a11 | cystine/glutamate transporter | Q9WTR6 |
Sod2 | superoxide dismutase [Mn], mitochondrial | P09671 |
Spata18 | mitochondria-eating protein | Q0P557 |
Stag1 | cohesin subunit SA-1 | Q9D3E6 |
Stx6 | syntaxin-6 | Q9JKK1 |
Sub1 | activated RNA polymerase II transcriptional coactivator p15 | P11031 |
Sulf2 | extracellular sulfatase Sulf-2 | Q8CFG0 |
Susd6 | sushi domain-containing protein 6 | Q8BGE4 |
Syk | tyrosine-protein kinase SYK | P48025 |
Tbxas1 | thromboxane-A synthase | P36423 |
Tdg | G/T mismatch-specific thymine DNA glycosylase | P56581 |
Tfap2a | transcription factor AP-2-alpha | P34056 |
Tfap2c | transcription factor AP-2 gamma | Q61312 |
Tff2 | trefoil factor 2 | Q03404 |
Tgfa | protransforming growth factor alpha preproprotein | P48030 |
Tgm2 | protein-glutamine gamma-glutamyltransferase 2 | P21981 |
Tigar | fructose-2,6-bisphosphatase TIGAR | Q8BZA9 |
Tlr1 | Toll-like receptor 1 | B9EJ46 |
Tlr2 | toll-like receptor 2 | Q9QUN7 |
Tlr3 | toll-like receptor 3 | Q99MB1 |
Tlr4 | toll-like receptor 4 | Q9QUK6 |
Tlr5 | toll-like receptor 5 | Q9JLF7 |
Tlr6 | toll-like receptor 6 | Q9EPW9 |
Tlr8 | toll-like receptor 8 | P58682 |
Tnfrsf10b | tumor necrosis factor receptor superfamily member 10B | Q9QZM4 |
Tnfrsf1a | tumor necrosis factor receptor superfamily member 1A | P25118 |
Tnfsf9 | tumor necrosis factor ligand superfamily member 9 | P41274 |
Tp53 | cellular tumor antigen p53 | P02340 |
Tp53bp1 | TP53-binding protein 1 | P70399 |
Tp53i3 | quinone oxidoreductase PIG3 | Q53FA7 |
Tp53inp1 | tumor protein p53-inducible nuclear protein 1 | Q9QXE4 |
Tp63 | tumor protein 63 | O88898 |
Tp73 | tumor protein p73 | Q9JJP2 |
Tpt1 | translationally-controlled tumor protein | P63028 |
Traf4 | TNF receptor-associated factor 4 | Q61382 |
Triap1 | TP53-regulated inhibitor of apoptosis 1 | Q9D8Z2 |
Trim32 | E3 ubiquitin-protein ligase TRIM32 | Q8CH72 |
Trpc7 | short transient receptor potential channel 7 | Q9WVC5 |
Tsc2 | tuberin 6 | Q61037 |
Tyrp1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase | P07147 |
Ubd | ubiquitin D | P63072 |
Ubtd1 | ubiquitin domain-containing protein 1 | Q91WB7 |
Ulk1 | serine/threonine-protein kinase ULK1 | O70405 |
Ulk2 | serine/threonine-protein kinase ULK2 | Q9QY01 |
Unc5a | netrin receptor UNC5A | Q8K1S4 |
Utf1 | undifferentiated embryonic cell transcription factor 1 | Q6J1H4 |
Vcan | versican core protein | Q62059 |
Vdr | vitamin D3 receptor | P48281 |
Xpc | DNA repair protein complementing XP-C cells homolog | P51612 |
Xpo1 | exportin-1 | Q6P5F9 |
Ypel3 | protein yippee-like 3 | P61237 |
Ywhag | 14-3-3 protein gamma | P61982 |
Zfp36 | mRNA decay activator protein ZFP36 | P22893 |
Zmat3 | zinc finger matrin-type protein 3 | O54836 |
Znf579 | zinc finger protein 579 | Q80VM4 |
Gene Symbol | Protein Name | UniProt Number |