National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)


p53 Target Genes

p53 regulated genes curated by M. Fisher (Fischer M. Census and evaluation of p53 target genes. Oncogene. 2017; 36: 3943-3956. PMID: 28288132). All genes have been converted to mouse.

Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project.

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Gene Symbol Protein Name UniProt Number
Abca12 glucosylceramide transporter ABCA12 E9Q876
Abcc1 multidrug resistance protein 1 O35379
Acad11 acyl-CoA dehydrogenase family member 11 Q80XL6
Acta2 actin, aortic smooth muscle P62737
Aen apoptosis-enhancing nuclease  Q9CZI9
Afp alpha-fetoprotein  P02772
Agt angiotensinogen  P11859
Agtr1a type-1 angiotensin II receptor P29754
Aifm1 apoptosis-inducing factor 1, mitochondrial  Q9Z0X1
Aifm2 ferroptosis suppressor protein 1  Q8BUE4
Alox5 polyunsaturated fatty acid 5-lipoxygenase P48999
Anln anillin  Q8K298
Anxa1 annexin A1 P10107
Apaf1 apoptotic protease-activating factor 1  O88879
Apc adenomatous polyposis coli protein  Q61315
Apex1 DNA-(apurinic or apyrimidinic site) endonuclease P28352
Apob apolipoprotein B-100  E9Q414
Apobec1 C->U-editing enzyme APOBEC-1 P51908
Ar androgen receptor P19091
Arid3a AT-rich interactive domain-containing protein 3A  Q62431
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 Q61324
Atf3 cyclic AMP-dependent transcription factor ATF-3 Q60765
Atr serine/threonine-protein kinase ATR Q9JKK8
Bak1 bcl-2 homologous antagonist/killer O08734
Banp protein BANP  Q8VBU8
Bax apoptosis regulator BAX Q07813
Bbc3 bcl-2-binding component 3  Q99ML1
Bcl2 apoptosis regulator Bcl-2  P10417
Bcl2l14 apoptosis facilitator Bcl-2-like protein 14 Q9CPT0
Bcl6 B-cell lymphoma 6 protein homolog P41183
Bdkrb2 B2 bradykinin receptor P32299
Bhlhe40 class E basic helix-loop-helix protein 40 O35185
Bid BH3-interacting domain death agonist P70444
Birc5 baculoviral IAP repeat-containing protein 5  O70201
Bnip3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 O55003
Bnip3l BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Q9Z2F7
Brca2 breast cancer type 2 susceptibility protein homolog P97929
Btg2 protein BTG2 Q04211
Btg3 protein BTG3 P50615
Casp1 caspase-1 P29452
Casp6 caspase-6  O08738
Cav1 caveolin-1  P49817
Cbg corticosteroid-binding globulin Q06770
Cbl E3 ubiquitin-protein ligase CBL P22682
Ccn3 CCN family member 3 Q64299
Ccnb1 G2/mitotic-specific cyclin-B1 P24860
Ccnb2 G2/mitotic-specific cyclin-B2 P30276
Ccng1 cyclin-G1 P51945
Ccnk cyclin-K O88874
Cd44 CD44 antigen P15379
Cd82 CD82 antigen P40237
Cdc20 cell division cycle protein 20 homolog Q9JJ66
Cdc25b M-phase inducer phosphatase 2  P30306
Cdc25c M-phase inducer phosphatase 3 P48967
Cdip1 cell death-inducing p53-target protein 1  Q9DB75
Cdk1 cyclin-dependent kinase 1 P11440
Cdkn1a cyclin-dependent kinase inhibitor 1 P39689
Cdkn2a cyclin-dependent kinase inhibitor 2A p16INK4a P51480
Cel bile salt-activated lipase  Q64285
Cers6 ceramide synthase 6  Q8C172
Ces2 cocaine esterase  Q91WG0
Chek1 serine/threonine-protein kinase Chk1 O35280
Chmp4c charged multivesicular body protein 4c Q9D7F7
Ckm creatine kinase M-type P07310
Cks2 cyclin-dependent kinases regulatory subunit 2 P56390
Col18a1 collagen alpha-1(XVIII) chain  P39061
Comt catechol O-methyltransferase O88587
Cpt1c carnitine O-palmitoyltransferase 1, brain isoform  Q8BGD5
Cryz quinone oxidoreductase P47199
Csf1 macrophage colony-stimulating factor 1   P07141
Cst3 cystatin-C  P21460
Ctf1 cardiotrophin-1  Q60753
Ctsd cathepsin D  P18242
Cx3cl1 fractalkine  O35188
Cyfip2 cytoplasmic FMR1-interacting protein 2 Q5SQX6
Cyp21  steroid 21-hydroxylase P03940
Dapk1 death-associated protein kinase 1  Q80YE7
Ddb2 DNA damage-binding protein 2  Q99J79
Ddr1 epithelial discoidin domain-containing receptor 1   Q03146
Def6 differentially expressed in FDCP 6 Q8C2K1
Dgkz diacylglycerol kinase zeta  Q80UP3
Dhrs3 short-chain dehydrogenase/reductase 3  O88876
Dkk1 dickkopf-related protein 1  O54908
Dnmt1 DNA (cytosine-5)-methyltransferase 1  P13864
Dram1 DNA damage-regulated autophagy modulator protein 1 Q9DC58
Dsp desmoplakin E9Q557
Dusp1 dual specificity protein phosphatase 1 P28563
Dusp2 dual specificity protein phosphatase 2 Q05922
Dusp4 dual specificity protein phosphatase 4 Q8BFV3
Dusp5 dual specificity protein phosphatase 5 Q1HL35
Dusp6 dual specificity protein phosphatase 6 Q9DBB1
Dut deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial  Q9CQ43
E2f7 transcription factor E2F7 Q6S7F2
Ect2 protein ECT2  Q07139
Eda2r tumor necrosis factor receptor superfamily member 27 Q8BX35
Edn2 endothelin-2 preproprotein P22389
Egfr epidermal growth factor receptor   Q01279
Egr2 E3 SUMO-protein ligase EGR2  P08152
Epcam epithelial cell adhesion molecule  Q99JW5
Epha2 ephrin type-A receptor 2  Q03145
Erap1 endoplasmic reticulum aminopeptidase 1  Q9EQH2
Ercc1 DNA excision repair protein ERCC-1  P07903
Esr1 estrogen receptor  P19785
F2r proteinase-activated receptor 1  P30558
Fancc Fanconi anemia group C protein homolog  P50652
Fas tumor necrosis factor receptor superfamily member 6   P25446
Fbxo22 F-box only protein 22 Q78JE5
Fdft1 squalene synthase P53798
Fdps farnesyl pyrophosphate synthase   Q920E5
Fdxr NADPH:adrenodoxin oxidoreductase, mitochondrial  Q61578
Flt1 vascular endothelial growth factor receptor 1   P35969
Fos protein c-Fos P01101
Foxf1 forkhead box protein F1 Q61080
Foxp3 forkhead box protein P3 Q99JB6
Fuca1 tissue alpha-L-fucosidase  Q99LJ1
Fzd2 frizzled-2  Q9JIP6
Gad2 glutamate decarboxylase 2 P48320
Gadd45a growth arrest and DNA damage-inducible protein GADD45 alpha P48316
Gamt guanidinoacetate N-methyltransferase  O35969
Gbp1 guanylate-binding protein 1 Q01514
Gch1 GTP cyclohydrolase 1 Q05915
Gdf15 growth/differentiation factor 15 preproprotein Q9Z0J7
Gdf9 growth/differentiation factor 9  Q07105
Gfi1 zinc finger protein Gfi-1  P70338
Gls2 glutaminase liver isoform, mitochondrial  Q571F8
Gpr87 G-protein coupled receptor 87 Q99MT7
Gpx1 glutathione peroxidase 1  P11352
Gstp1 glutathione S-transferase P 1 P19157
Hamp hepcidin preproprotein Q9EQ21
Hdc histidine decarboxylase P23738
Hic1 hypermethylated in cancer 1 protein  Q9R1Y5
Hmgcll1 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic Q8JZS7
Hmgcr 3-hydroxy-3-methylglutaryl-coenzyme A reductase  Q01237
Hnf4a hepatocyte nuclear factor 4-alpha isoform HNF4alpha10 P49698
Hpse heparanase preproprotein Q6YGZ1
Hras GTPase HRas  Q61411
Hsp90ab1 heat shock protein HSP 90-beta P11499
Hspa8 heat shock cognate 71 kDa protein  P63017
Htt huntingtin P42859
Id2 DNA-binding protein inhibitor ID-2 P41136
Ier3 radiation-inducible immediate-early gene IEX-1 P46694
Ier5 immediate early response gene 5 protein O89113
Igf1r insulin-like growth factor 1 receptor  Q60751
Igfbp3 insulin-like growth factor-binding protein 3  P47878
Irf2bp2 interferon regulatory factor 2-binding protein 2 E9Q1P8
Irf5 interferon regulatory factor 5  P56477
Irf9 interferon regulatory factor 9  Q61179
Iscu iron-sulfur cluster assembly enzyme ISCU, mitochondrial  Q9D7P6
Kiaa0513 uncharacterized protein KIAA0513 homolog  Q8R0A7
Kitlg kit ligand  P20826
Krt14 keratin, type I cytoskeletal 14  Q61781
Krt8 keratin, type II cytoskeletal 8 P11679
Larp1 la-related protein 1 Q6ZQ58
Lasp1 LIM and SH3 domain protein 1 Q61792
Ldlr low-density lipoprotein receptor  presursor  P35951
Lgals3 galectin-3 P16110
Lif leukemia inhibitory factor  P09056
Limk2 LIM domain kinase 2  O54785
Lmna prelamin-A/C   P48678
Lonp1 lon protease homolog, mitochondrial  Q8CGK3
Lpin1 phosphatidate phosphatase LPIN1  Q91ZP3
Mad1l1 mitotic spindle assembly checkpoint protein MAD1  Q9WTX8
Map4 microtubule-associated protein 4  P27546
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4  P97820
Mapk8 mitogen-activated protein kinase 8  Q91Y86
Mb myoglobin P04247
Mdm2 E3 ubiquitin-protein ligase Mdm2  P23804
Me1 NADP-dependent malic enzyme  P06801
Me2 NAD-dependent malic enzyme, mitochondrial  Q99KE1
Me3 NADP-dependent malic enzyme, mitochondrial Q8BMF3
Met hepatocyte growth factor receptor  P16056
Mfn2 mitofusin-2 Q80U63
Mlh1 DNA mismatch repair protein Mlh1  Q9JK91
Mmp2 72 kDa type IV collagenase preproprotein P33434
Mpzl2 myelin protein zero-like protein 2  O70255
Msh2 DNA mismatch repair protein Msh2 P43247
Mta1 metastasis-associated protein MTA1  Q8K4B0
Mvk mevalonate kinase  Q9R008
Myc myc proto-oncogene protein  P01108
Myog myogenin P12979
Nanog homeobox protein NANOG  Q5TM83
Ncf2 neutrophil cytosol factor 2 O70145
Ndrg1 protein NDRG1 Q62433
Nek2 serine/threonine-protein kinase Nek2 O35942
Ninj1 ninjurin-1 O70131
Nlrc4 NLR family CARD domain-containing protein 4 Q3UP24
Nol3 nucleolar protein 3 Q9D1X0
Nos3 nitric oxide synthase, endothelial P70313
Notch1 neurogenic locus notch homolog protein 1  Q01705
Nr0b2 nuclear receptor subfamily 0 group B member 2 Q62227
Nsg1 neuronal vesicle trafficking-associated protein 1 Q62092
Odc1 ornithine decarboxylase P00860
Ogn mimecan  Q62000
Orm2 alpha-1-acid glycoprotein 2  P07361
Padi4 protein-arginine deiminase type-4 Q9Z183
Pank1 pantothenate kinase 1  Q8K4K6
Pank2 pantothenate kinase 2, mitochondrial  Q7M753
Pax2 paired box protein Pax-2  P32114
Pcbp4 poly(rC)-binding protein 4 P57724
Pcdh10 protocadherin-10   Q6P0A6
Pcna proliferating cell nuclear antigen P17918
Pebp1 phosphatidylethanolamine-binding protein 1 P70296
Perp p53 apoptosis effector related to PMP-22 Q9JK95
Pgf placenta growth factor  P49764
Phf1 PHD finger protein 1  Q9Z1B8
Phlda3 pleckstrin homology-like domain family A member 3 Q9WV95
Pidd1 p53-induced death domain-containing protein 1  Q9ERV7
Pik3ca phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha P42337
Pkd1 polycystin-1  O08852
Plagl1 zinc finger protein PLAGL1  O35745
Plk1 serine/threonine-protein kinase PLK1 Q07832
Plk2 serine/threonine-protein kinase PLK2 P53351
Plk3 serine/threonine-protein kinase PLK3  Q60806
Pltp phospholipid transfer protein  P55065
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 Q9JM54
Pml protein PML  Q60953
Pms2 mismatch repair endonuclease PMS2 P54279
Pold1 DNA polymerase delta catalytic subunit P52431
Polh DNA polymerase eta  Q9JJN0
Pomc pro-opiomelanocortin preproprotein P01193
Ppargc1a peroxisome proliferator-activated receptor gamma coactivator 1-alpha  O70343
Ppargc1b peroxisome proliferator-activated receptor gamma coactivator 1-beta  Q8VHJ7
Ppm1d protein phosphatase 1D Q9QZ67
Ppm1j protein phosphatase 1J Q149T7
Prap1 proline-rich acidic protein 1  Q80XD8
Prc1 protein regulator of cytokinesis 1 Q99K43
Prdm1 PR domain zinc finger protein 1  Q60636
Prkab1 5'-AMP-activated protein kinase subunit beta-1 Q9R078
Prodh proline dehydrogenase 1, mitochondrial  Q9WU79
Prom1 prominin-1  O54990
Psrc1 proline/serine-rich coiled-coil protein 1 Q9D0P7
Ptchd4 patched domain-containing protein 4  B9EKX1
Pten PI- 3,4,5-P 3-phosphatase and dual-specificity protein phosphatase O08586
Ptgs2 prostaglandin G/H synthase 2  Q05769
Ptk2 focal adhesion kinase 1  P34152
Ptp4a1 protein tyrosine phosphatase type IVA 1 Q63739
Ptpn6 tyrosine-protein phosphatase non-receptor type 6  P29351
Ptprv receptor-type tyrosine-protein phosphatase V P70289
Pttg1 securin  Q9CQJ7
Pycard apoptosis-associated speck-like protein containing a CARD Q9EPB4
Rab6a ras-related protein Rab-6A P35279
Rabggta geranylgeranyl transferase type-2 subunit alpha Q9JHK4
Rad17 cell cycle checkpoint protein RAD17  Q6NXW6
Rad23a UV excision repair protein RAD23 homolog A  P54726
Rad51 DNA repair protein RAD51 homolog 1 Q08297
Rap2b ras-related protein Rap-2b P61226
Rara retinoic acid receptor alpha  P11416
Rarres2 retinoic acid receptor responder protein 2 Q9DD06
Rb1 retinoblastoma-associated protein P13405
Rbm38 RNA-binding protein 38 Q62176
Rbpj recombining binding protein suppressor of hairless  P31266
Rchy1 RING finger and CHY zinc finger domain-containing protein 1  Q9CR50
Recql4 ATP-dependent DNA helicase Q4 Q75NR7
Rfc4 replication factor C subunit 4 Q99J62
Rgcc regulator of cell cycle RGCC Q9DBX1
Rhoc rho-related GTP-binding protein RhoC Q62159
Rnd3 rho-related GTP-binding protein RhoE P61588
Rnf144b E3 ubiquitin-protein ligase RNF144B Q8BKD6
Rps27l 40S ribosomal protein S27-like  Q6ZWY3
Rrad GTP-binding protein RAD O88667
Rrm2b ribonucleoside-diphosphate reductase subunit M2 B  Q6PEE3
Rtn4 reticulon-4  Q99P72
S100a2 S100 calcium binding protein A2 J3QMC7
S100a9 protein S100-A9 P31725
Sall2 sal-like protein 2  Q9QX96
Scd1 Acyl-CoA desaturase 1 P13516
Scn3b sodium channel subunit beta-3  Q8BHK2
Sema3b semaphorin-3B  Q62177
Sema3f semaphorin-3F   O88632
Serpina6 corticosteroid-binding globulin  Q06770
Serpinb5 serpin B5  P70124
Serpine1 plasminogen activator inhibitor 1  P22777
Sesn1 sestrin-1  P58006
Sgk1 serine/threonine-protein kinase Sgk1  Q9WVC6
Sh2d1a SH2 domain-containing protein 1A  O88890
Shbg sex hormone-binding globulin  P97497
Siah1 E3 ubiquitin-protein ligase SIAH1 P61092
Siva1 apoptosis regulatory protein Siva  O54926
Slc2a4 solute carrier family 2, facilitated glucose transporter member 4  P14142
Slc38a2 sodium-coupled neutral amino acid transporter 2  Q8CFE6
Slc6a6 sodium- and chloride-dependent taurine transporter O35316
Slc7a11 cystine/glutamate transporter Q9WTR6
Sod2 superoxide dismutase [Mn], mitochondrial  P09671
Spata18 mitochondria-eating protein Q0P557
Stag1 cohesin subunit SA-1  Q9D3E6
Stx6 syntaxin-6 Q9JKK1
Sub1 activated RNA polymerase II transcriptional coactivator p15 P11031
Sulf2 extracellular sulfatase Sulf-2   Q8CFG0
Susd6 sushi domain-containing protein 6   Q8BGE4
Syk tyrosine-protein kinase SYK P48025
Tbxas1 thromboxane-A synthase P36423
Tdg G/T mismatch-specific thymine DNA glycosylase  P56581
Tfap2a transcription factor AP-2-alpha  P34056
Tfap2c transcription factor AP-2 gamma  Q61312
Tff2 trefoil factor 2  Q03404
Tgfa protransforming growth factor alpha  preproprotein P48030
Tgm2 protein-glutamine gamma-glutamyltransferase 2 P21981
Tigar fructose-2,6-bisphosphatase TIGAR Q8BZA9
Tlr1 Toll-like receptor 1 B9EJ46
Tlr2 toll-like receptor 2  Q9QUN7
Tlr3 toll-like receptor 3  Q99MB1
Tlr4 toll-like receptor 4  Q9QUK6
Tlr5 toll-like receptor 5  Q9JLF7
Tlr6 toll-like receptor 6  Q9EPW9
Tlr8 toll-like receptor 8  P58682
Tnfrsf10b tumor necrosis factor receptor superfamily member 10B  Q9QZM4
Tnfrsf1a tumor necrosis factor receptor superfamily member 1A P25118
Tnfsf9 tumor necrosis factor ligand superfamily member 9 P41274
Tp53 cellular tumor antigen p53  P02340
Tp53bp1 TP53-binding protein 1  P70399
Tp53i3 quinone oxidoreductase PIG3 Q53FA7
Tp53inp1 tumor protein p53-inducible nuclear protein 1  Q9QXE4
Tp63 tumor protein 63  O88898
Tp73 tumor protein p73  Q9JJP2
Tpt1 translationally-controlled tumor protein P63028
Traf4 TNF receptor-associated factor 4 Q61382
Triap1 TP53-regulated inhibitor of apoptosis 1 Q9D8Z2
Trim32 E3 ubiquitin-protein ligase TRIM32 Q8CH72
Trpc7 short transient receptor potential channel 7  Q9WVC5
Tsc2 tuberin 6 Q61037
Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase  P07147
Ubd ubiquitin D P63072
Ubtd1 ubiquitin domain-containing protein 1 Q91WB7
Ulk1 serine/threonine-protein kinase ULK1  O70405
Ulk2 serine/threonine-protein kinase ULK2 Q9QY01
Unc5a netrin receptor UNC5A   Q8K1S4
Utf1 undifferentiated embryonic cell transcription factor 1 Q6J1H4
Vcan versican core protein   Q62059
Vdr vitamin D3 receptor P48281
Xpc DNA repair protein complementing XP-C cells homolog P51612
Xpo1 exportin-1 Q6P5F9
Ypel3 protein yippee-like 3  P61237
Ywhag 14-3-3 protein gamma P61982
Zfp36 mRNA decay activator protein ZFP36 P22893
Zmat3 zinc finger matrin-type protein 3 O54836
Znf579 zinc finger protein 579 Q80VM4

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Gene Symbol Protein Name UniProt Number