Epithelial Systems Biology Laboratory, NHLBI, NIH  
  RNA-seq Identification of Transcripts Expressed along the Renal Tubule  
   
         

Protein Kinases

This database provides median RPKM values for each protein kinase transcript in 14 separate renal tubule segments in untreated male Sprague-Dawley rats (200-250 g BW). At least 4 replicates were analyzed for each segment. Rat renal tubule segments were manually dissected under a high-resolution stereomicroscope. Cells were lysed in a lysis buffer containing reverse transcriptase and oligo-dT primer. After reverse transcription of poly(A)-tailed mRNA transcripts, cDNAs were amplified and sequenced using an Illumina HiSeq 2000 sequencer. FASTQ sequences were mapped to rat reference genome rn5. Database created by Jae Wook Lee and Mark A. Knepper. Please address questions to knep@helix.nih.gov. Back to Index Page.

Terminology for renal tubule segments: S1, first segment of the proximal tubule; S2, second segment of the proximal tubule; S3, third segment of the proximal tubule; SDL, short descending limb of the loop of Henle; LDLOM, long descending limb of the loop of Henle in the outer medulla; LDLIM, long descending limb of the loop of Henle in the inner medulla; tAL, thin ascending limb of the loop of Henle; mTAL, medullary thick ascending limb of the loop of Henle; cTAL, cortical thick ascending limb of the loop of Henle; DCT, distal convoluted tubule; CNT, connecting tubule; CCD, cortical collecting duct; OMCD, outer medullary collecting duct; IMCD, inner medullary collecting duct. Note that "nephron" refers to renal tubule segments from S1 Proximal through DCT, whereas "collecting duct" refers to segments from CNT through IMCD.

Database is hosted by the Epithelial Systems Biology Laboratory, National Heart, Lung and Blood Institute (Intramural Research Program, NIH) as part of its Kidney Systems Biology Project. Please cite: Lee JW, Chou CL, Knepper MA. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol. 2015 PMID: 25817355.

How to search the database: Please use FIND ('Control-F') function provided by your web browser to search for a specific gene symbol.

RPKM Values for Protein Kinase mRNAs in Renal Tubule Segments:
Gene Symbol Description/Annotation S1 S2 S3 SDL LDLOM LDLIM tAL mTAL cTAL DCT CNT CCD OMCD IMCD
Aak1 AP2-associated protein kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Aatk serine/threonine-protein kinase LMTK1 isoform X4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Abl1 tyrosine-protein kinase ABL1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Abl2 tyrosine-protein kinase ABL2 isoform X11 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Acvr1 activin receptor type-1 precursor 0.0 0.4 0.0 0.0 0.0 9.6 0.1 0.0 0.2 0.0 0.0 0.0 0.0 1.1
Acvr1b activin receptor type-1B precursor 0.1 0.7 0.0 0.1 0.1 2.1 5.3 0.4 8.3 2.5 6.9 6.1 3.7 1.2
Acvr1c activin receptor type-1C precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Acvr2a activin receptor type-2A precursor 0.0 0.7 0.0 0.0 0.0 7.0 0.2 0.0 2.9 0.2 1.0 4.7 0.0 0.6
Acvr2b activin receptor type-2B precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0
Acvrl1 serine/threonine-protein kinase receptor R3 precursor 0.0 0.0 0.1 0.9 0.1 0.0 0.0 0.0 0.1 0.3 0.0 2.3 0.0 0.2
Adck1 aarF domain containing kinase 1 0.0 0.0 0.1 9.5 0.9 1.4 27.4 0.0 5.8 5.8 1.5 0.9 0.1 2.6
Adck2 aarF domain containing kinase 2 0.1 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.5 2.0 0.9 3.9 0.0 1.9
Adck3 chaperone activity of bc1 complex-like, mitochondrial 0.8 5.4 0.2 0.2 0.1 0.0 0.7 17.8 10.4 24.3 9.9 24.9 0.2 0.0
Adck4 aarF domain-containing protein kinase 4 0.1 7.4 2.0 0.0 0.0 22.4 12.0 0.0 7.5 10.9 2.2 13.4 0.0 4.7
Adck5 aarF domain containing kinase 5 3.3 0.1 3.4 0.7 0.2 4.8 2.1 0.1 6.7 19.7 0.3 8.3 1.2 29.3
Adrbk1 beta-adrenergic receptor kinase 1 0.0 0.2 1.9 0.1 0.0 2.7 0.1 0.0 0.9 3.2 0.9 1.4 2.4 3.2
Adrbk2 beta-adrenergic receptor kinase 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Akt1 RAC-alpha serine/threonine-protein kinase 9.4 7.3 0.7 24.3 11.0 51.1 35.1 3.3 34.8 60.5 23.8 39.6 52.2 53.9
Akt2 RAC-beta serine/threonine-protein kinase 0.4 4.7 0.2 16.4 0.1 38.5 3.5 0.0 9.6 17.9 1.3 23.0 0.1 14.1
Akt3 RAC-gamma serine/threonine-protein kinase 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4
Alk ALK tyrosine kinase receptor precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Alpk3 alpha-protein kinase 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Amhr2 anti-Muellerian hormone type-2 receptor precursor 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 2.1 2.7 0.1 0.2 0.0
Araf serine/threonine-protein kinase A-Raf isoform 2 0.1 1.3 0.0 3.6 0.0 4.1 0.1 0.0 0.7 2.0 2.1 2.9 0.1 1.9
Atm serine-protein kinase ATM 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.4
Aurka aurora kinase A 1.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.4 0.9 3.6 0.3 1.6
Aurkb aurora kinase B 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.1 0.2 0.0 0.0
Aurkc serine/threonine-protein kinase 13 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.2 1.1 1.7 2.2 0.0 0.2
Axl tyrosine-protein kinase receptor UFO isoform 1 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.3 0.0 0.0 0.0 0.0
Bckdk [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor 17.6 18.6 13.8 35.5 16.8 7.7 35.6 3.1 23.4 35.9 12.8 25.1 12.9 17.6
Blk tyrosine-protein kinase Blk 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Bmpr1a bone morphogenetic protein receptor type-1A precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.6 0.4 2.4 0.0 1.8
Bmpr1b bone morphogenetic protein receptor, type IB 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 2.3 0.3 0.3
Bmpr2 bone morphogenetic protein receptor type-2 precursor 0.0 0.1 0.0 0.3 0.0 5.2 11.1 0.0 1.3 0.1 0.3 1.0 0.0 1.9
Bmx cytoplasmic tyrosine-protein kinase BMX 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Brsk1 serine/threonine-protein kinase BRSK1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Btk tyrosine-protein kinase BTK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Bub1 mitotic checkpoint serine/threonine-protein kinase BUB1 2.0 2.0 0.2 1.5 0.0 1.7 1.0 0.0 1.1 1.3 5.0 2.0 0.0 0.3
Camk1 calcium/calmodulin-dependent protein kinase type 1 0.7 5.1 6.1 1.7 0.7 17.4 13.0 4.1 3.5 12.7 6.7 20.6 1.3 11.2
Camk1d calcium/calmodulin-dependent protein kinase type 1D 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7
Camk1g calcium/calmodulin-dependent protein kinase type 1G 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Camk2a calcium/calmodulin-dependent protein kinase type II subunit alpha 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0
Camk2b calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Camk2d calcium/calmodulin-dependent protein kinase type II subunit delta 0.0 0.0 0.0 0.3 0.5 10.1 0.2 0.0 1.1 0.1 0.1 0.4 0.1 3.8
Camk2g calcium/calmodulin-dependent protein kinase type II subunit gamma 0.0 0.0 0.0 6.4 0.0 13.4 0.1 0.0 0.7 5.5 0.9 6.9 0.0 0.0
Camk4 calcium/calmodulin-dependent protein kinase type IV 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 3.2 0.0 0.0 0.0 0.0
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 0.0 0.0 0.0 0.1 0.0 9.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 15.6
Camkv caM kinase-like vesicle-associated protein 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Cask peripheral plasma membrane protein CASK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Cdc42bpa serine/threonine-protein kinase MRCK alpha 0.1 0.2 0.0 0.0 0.0 5.6 10.2 0.0 4.4 0.3 0.3 0.0 0.0 1.8
Cdc42bpb serine/threonine-protein kinase MRCK beta 0.0 0.4 0.0 0.6 0.0 0.4 0.0 0.1 0.5 0.6 1.3 1.2 0.2 1.9
Cdc42bpg serine/threonine-protein kinase MRCK gamma 0.1 0.0 0.6 0.2 0.1 0.8 0.3 0.0 1.0 10.5 2.2 9.0 0.5 2.7
Cdc7 cell division cycle 7-related protein kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Cdk1 cyclin-dependent kinase 1 0.1 6.3 1.1 0.0 0.0 0.0 0.0 0.1 2.7 0.7 0.1 3.1 11.3 0.0
Cdk10 cyclin-dependent kinase 10 isoform 2 0.4 10.2 9.6 8.4 0.1 2.3 4.4 0.0 3.8 3.2 3.2 4.8 0.1 12.8
Cdk11b cyclin-dependent kinase 11B 1.5 8.0 10.8 2.7 11.7 20.1 1.1 1.1 5.7 3.6 8.1 6.6 0.3 17.7
Cdk12 cyclin-dependent kinase 12 isoform 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.3 0.4 0.5 0.0 1.3
Cdk13 cell division protein kinase 13 isoform 2 0.7 1.0 0.0 0.0 0.1 2.6 3.7 0.0 2.0 2.3 1.1 4.2 0.0 3.0
Cdk14 cell division protein kinase 14 1.6 2.2 0.0 0.2 0.0 4.3 0.0 0.0 1.9 7.5 5.5 10.3 0.1 0.1
Cdk16 cyclin-dependent kinase 16 isoform a 5.1 1.6 2.7 0.7 0.0 17.2 14.7 0.1 10.8 11.7 12.5 20.2 0.9 26.3
Cdk17 cyclin-dependent kinase 17 0.0 0.0 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.2 3.4 0.3 0.0 2.4
Cdk18 cyclin-dependent kinase 18 0.1 8.8 0.1 0.7 0.1 1.5 0.1 0.2 2.4 1.3 8.7 8.6 29.7 40.1
Cdk19 cyclin-dependent kinase 19 0.1 2.7 0.0 1.2 0.2 1.8 0.1 0.1 2.0 0.1 4.6 2.0 0.0 8.4
Cdk2 cyclin-dependent kinase 2 0.0 0.0 0.0 7.8 0.2 2.8 0.1 0.1 0.1 0.4 3.2 5.8 0.0 0.0
Cdk20 cyclin-dependent kinase 20 0.1 6.7 0.4 0.0 0.0 3.6 0.0 0.0 2.9 0.0 0.0 0.9 0.0 1.2
Cdk4 cyclin-dependent kinase 4 13.8 27.0 7.8 69.8 37.5 51.8 71.6 23.1 29.0 34.2 42.8 44.8 21.0 64.0
Cdk5 cyclin-dependent kinase 5 0.1 12.5 0.5 0.3 0.1 29.0 0.1 0.1 8.0 9.4 3.7 20.7 0.1 2.0
Cdk6 cell division protein kinase 6 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 2.0 2.2 3.1 4.0 0.0 0.1
Cdk8 cyclin-dependent kinase 8 0.1 0.0 0.0 0.3 0.0 7.0 0.1 0.0 1.0 0.0 14.9 14.2 0.0 4.3
Cdk9 cyclin-dependent kinase 9 1.1 6.3 4.1 4.7 0.6 1.5 0.2 1.5 6.3 7.8 6.2 9.0 1.2 7.6
Cdkl1 cyclin-dependent kinase-like 1 92.6 46.4 35.7 402.3 272.4 579.1 157.1 147.7 202.4 119.5 151.3 213.9 385.1 192.9
Cdkl2 cyclin-dependent kinase-like 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Cdkl3 cyclin-dependent kinase-like 3 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.2 0.7 0.1 0.1 0.0 0.1
Chek1 serine/threonine-protein kinase Chk1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0
Chek2 serine/threonine-protein kinase Chk2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.7 0.0 0.2
Chuk inhibitor of nuclear factor kappa-B kinase subunit alpha 0.0 0.2 0.0 0.0 0.1 5.9 0.1 0.0 0.3 1.8 0.9 6.0 0.5 4.9
Cit citron Rho-interacting kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0
Clk1 dual specificity protein kinase CLK1 0.1 0.9 0.1 0.8 0.1 16.9 15.0 2.0 3.4 0.5 33.7 45.3 63.0 27.8
Clk2 dual specificity protein kinase CLK2 0.0 0.1 16.7 8.4 1.4 10.1 0.3 0.0 6.0 3.9 0.1 0.6 0.1 4.4
Clk3 dual specificity protein kinase CLK3 10.3 6.4 0.0 1.1 1.4 63.1 0.3 0.1 12.5 15.0 8.0 16.0 0.2 25.3
Clk4 CDC-like kinase 4 0.0 0.0 0.1 0.1 0.1 15.1 0.2 0.0 0.6 2.3 19.5 27.9 0.0 16.2
Csf1r macrophage colony-stimulating factor 1 receptor precursor 0.2 1.4 1.6 7.1 0.0 0.4 0.6 0.2 10.5 16.7 0.0 0.2 0.1 0.2
Csk tyrosine-protein kinase CSK 0.1 0.2 0.1 0.8 0.0 0.2 0.1 0.0 4.4 2.5 3.4 9.7 0.0 5.8
Csnk1a1 casein kinase I isoform alpha 0.2 0.0 0.0 2.8 0.7 33.0 29.7 0.2 4.1 1.3 10.4 27.8 0.2 13.7
Csnk1d casein kinase I isoform delta 0.5 0.9 1.6 8.9 0.2 13.8 2.0 0.4 6.4 8.0 6.8 10.2 3.8 22.5
Csnk1e casein kinase I isoform epsilon 0.0 0.0 0.1 0.6 0.2 20.7 12.3 0.0 2.9 1.8 0.1 11.8 0.7 20.2
Csnk1g1 casein kinase I isoform gamma-1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1
Csnk1g2 casein kinase I isoform gamma-2 isoform 1 3.5 3.8 4.0 42.6 41.8 55.2 46.1 0.4 8.9 14.4 11.7 23.4 16.0 34.8
Csnk1g3 casein kinase I isoform gamma-3 0.0 1.0 0.3 0.0 0.0 7.9 0.1 0.3 2.0 0.5 0.0 3.9 0.0 0.7
Csnk2a1 casein kinase II subunit alpha 0.3 3.3 1.4 2.1 18.3 17.0 0.5 1.6 11.4 3.5 3.1 7.4 6.4 17.1
Csnk2a2 casein kinase II subunit alpha' 0.1 0.4 0.0 0.0 0.0 4.6 0.5 0.0 1.5 0.2 0.4 0.4 0.5 3.3
Dapk1 death-associated protein kinase 1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 5.2 4.1 1.1 0.0 0.0 1.2
Dapk2 death-associated protein kinase 2 0.0 0.4 0.0 0.0 0.0 1.1 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Dapk3 death-associated protein kinase 3 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.5
Dclk1 serine/threonine-protein kinase DCLK1 isoform 1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Dclk2 serine/threonine-protein kinase DCLK2 isoform a 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Dclk3 serine/threonine-protein kinase DCLK3 7.1 5.6 0.1 4.8 0.1 4.8 0.0 0.1 5.1 4.8 0.5 6.4 4.0 18.0
Ddr1 epithelial discoidin domain-containing receptor 1 precursor 0.3 1.1 3.7 14.8 6.2 14.1 0.5 0.2 19.0 13.9 9.0 32.5 4.7 14.6
Ddr2 discoidin domain-containing receptor 2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Dstyk dual serine/threonine and tyrosine protein kinase 0.3 0.0 0.0 0.0 0.0 0.6 0.1 0.0 2.0 0.4 0.9 0.8 0.1 1.5
Dyrk1a dual specificity tyrosine-phosphorylation-regulated kinase 1A 0.6 1.6 0.0 8.0 0.0 8.4 0.4 0.3 5.8 5.2 6.9 2.9 2.0 9.0
Dyrk1b dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.0 1.7 0.3 0.1 0.1 1.7 0.1 0.0 1.1 2.1 0.1 1.1 0.0 0.9
Dyrk2 dual specificity tyrosine-phosphorylation-regulated kinase 2 0.0 0.4 0.0 0.0 0.0 8.6 0.0 0.0 0.1 0.1 0.5 1.2 0.0 0.5
Dyrk3 dual specificity tyrosine-phosphorylation-regulated kinase 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7
Eef2k eukaryotic elongation factor 2 kinase 0.2 0.0 0.0 0.0 0.0 1.3 0.1 0.0 3.2 3.6 0.1 4.7 0.0 5.0
Egfr epidermal growth factor receptor precursor 0.0 0.0 0.0 0.0 0.0 3.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 2.8
Eif2ak1 eukaryotic translation initiation factor 2-alpha kinase 1 0.1 0.8 0.4 0.0 11.7 4.4 6.0 0.3 13.9 5.5 11.7 21.1 0.3 35.2
Eif2ak2 interferon-induced, double-stranded RNA-activated protein kinase 0.1 0.1 0.0 3.5 0.0 18.7 4.6 0.0 5.3 3.1 0.2 0.6 0.0 5.0
Eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 precursor 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.6 1.2 0.0 1.5
Eif2ak4 eukaryotic translation initiation factor 2-alpha kinase 4 0.0 0.0 0.0 0.0 0.0 9.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 1.2
Epha1 ephrin type-A receptor 1 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Epha10 ephrin type-A receptor 10 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Epha2 ephrin type-A receptor 2 precursor 0.0 0.0 0.0 0.0 6.8 45.0 8.6 0.0 0.0 0.0 0.0 0.0 0.0 15.2
Epha3 ephrin type-A receptor 3 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Epha4 Eph receptor A4 precursor 0.0 0.0 0.1 1.2 2.4 57.4 8.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0
Epha5 ephrin type-A receptor 5 isoform 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Epha7 ephrin type-A receptor 7 precursor 0.0 0.0 0.0 0.8 3.4 12.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ephb1 ephrin type-B receptor 1 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0
Ephb2 ephrin type-B receptor 2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.8 2.7 0.5 0.0 0.0 0.0 0.0
Ephb3 ephrin type-B receptor 3 isoform X1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.5 0.5 0.0 0.0 0.0 0.1
Ephb6 ephrin type-B receptor 6 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.5
Erbb2 receptor tyrosine-protein kinase erbB-2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Erbb3 receptor tyrosine-protein kinase erbB-3 precursor 1.2 3.6 15.1 0.1 0.0 16.1 0.0 0.0 0.1 0.0 0.8 1.2 0.0 8.9
Erbb4 receptor tyrosine-protein kinase erbB-4 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 2.3 0.0 0.0 0.0 0.0 0.0
Ern1 serine/threonine-protein kinase/endoribonuclease IRE1 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.4
Ern2 serine/threonine-protein kinase/endoribonuclease IRE2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Fastk fas-activated serine/threonine kinase isoform X6 4.6 4.3 22.5 60.1 15.9 30.0 40.8 13.9 20.6 75.5 23.0 57.3 15.2 27.5
Fes tyrosine-protein kinase Fes/Fps 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9
Fgfr1 fibroblast growth factor receptor 1 precursor 3.0 7.6 0.1 1.5 0.1 10.6 5.9 0.7 14.1 8.5 4.8 2.3 0.0 23.4
Fgfr2 fibroblast growth factor receptor 2 isoform f 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.7 1.3 2.3 0.0 2.3
Fgfr3 fibroblast growth factor receptor 3 precursor 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.0 4.7 0.3 0.0 0.6
Fgfr4 fibroblast growth factor receptor 4 precursor 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0
Fgr tyrosine-protein kinase Fgr 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.0 0.0 0.0
Flt1 vascular endothelial growth factor receptor 1 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Flt3 FL cytokine receptor precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Flt4 vascular endothelial growth factor receptor 3 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Frk tyrosine-protein kinase FRK 0.0 0.0 0.0 0.8 0.0 19.1 0.1 0.0 1.4 0.0 5.2 9.5 0.1 5.0
Fyn tyrosine-protein kinase Fyn 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0
Gak cyclin-G-associated kinase 2.4 4.1 0.1 4.1 0.0 17.1 0.1 1.5 2.7 6.4 2.8 7.1 0.1 8.1
Grk1 rhodopsin kinase precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Grk4 G protein-coupled receptor kinase 4 0.8 0.0 0.1 0.0 0.3 0.4 0.0 0.8 2.1 5.0 2.2 3.3 0.0 2.4
Grk5 G protein-coupled receptor kinase 5 0.0 0.0 0.0 0.7 0.0 17.4 0.1 0.0 0.0 0.0 1.8 6.4 0.0 1.0
Grk6 G protein-coupled receptor kinase 6 isoform b 1.1 0.0 0.0 0.2 0.1 0.5 1.0 0.1 8.1 6.2 6.2 3.4 0.0 4.3
Gsk3a glycogen synthase kinase-3 alpha 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.1 0.0 0.2 0.0 0.7
Gsk3b glycogen synthase kinase-3 beta 0.3 0.1 0.1 0.5 0.0 11.9 2.6 0.0 1.7 0.5 3.6 4.0 0.0 1.8
Gucy2c heat-stable enterotoxin receptor precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Gucy2d olfactory guanylyl cyclase GC-D precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Gucy2e guanylyl cyclase GC-E precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Gucy2f retinal guanylyl cyclase 2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Gucy2g guanylate cyclase 2G 0.0 0.0 0.0 0.0 0.0 5.6 1.9 0.0 0.0 0.0 0.0 0.0 0.0 1.4
Hck tyrosine-protein kinase HCK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Hipk1 homeodomain-interacting protein kinase 1 0.1 0.2 0.3 13.8 3.3 33.5 49.5 0.0 2.5 8.2 5.1 13.0 0.1 25.0
Hipk2 homeodomain-interacting protein kinase 2 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.6 0.3 0.9 0.2 0.1 0.5
Hipk3 homeodomain-interacting protein kinase 3 0.0 1.2 1.1 0.0 0.0 21.1 8.7 1.2 0.7 1.5 3.1 5.2 0.1 7.4
Hipk4 homeodomain-interacting protein kinase 4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Hunk hormonally up-regulated neu tumor-associated kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ick serine/threonine-protein kinase ICK 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.6 0.6 0.8 0.0 0.7
Igf1r insulin-like growth factor 1 receptor precursor 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.9 0.1 0.1 0.0 0.0 0.1
Ikbkb inhibitor of nuclear factor kappa-B kinase subunit beta 0.0 0.1 0.1 0.1 0.0 4.6 9.8 0.0 5.7 2.1 0.0 5.6 0.0 5.2
Ikbke inhibitor of nuclear factor kappa-B kinase subunit epsilon 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3
Ilk integrin-linked protein kinase 44.9 14.5 18.6 55.0 46.9 21.0 42.1 8.6 17.6 31.8 27.7 31.4 8.6 36.0
Insr insulin receptor preproprotein 0.2 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.3 0.3 0.6 0.9 0.0 7.7
Insrr insulin receptor-related protein precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.4 68.5 0.4 0.0
Irak1 interleukin-1 receptor-associated kinase 1 0.1 8.6 0.5 0.2 0.1 0.7 5.1 5.7 2.3 4.6 7.6 8.0 0.0 22.1
Irak2 interleukin-1 receptor-associated kinase-like 2 0.4 0.1 0.0 3.7 0.0 2.9 14.2 0.0 0.4 2.0 2.7 2.8 9.1 16.4
Irak3 interleukin-1 receptor-associated kinase 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Irak4 interleukin-1 receptor-associated kinase 4 0.0 0.0 0.0 0.0 0.0 5.4 8.3 0.0 0.0 2.6 0.0 0.2 0.0 3.8
Itk tyrosine-protein kinase ITK/TSK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.1 0.0
Jak1 tyrosine-protein kinase JAK1 1.6 0.9 2.2 2.5 15.2 25.7 32.9 10.2 11.7 5.5 3.5 11.3 8.1 27.2
Jak2 tyrosine-protein kinase JAK2 0.0 0.1 0.0 0.1 0.0 11.0 0.1 0.0 0.8 1.3 0.1 0.5 0.0 5.8
Jak3 tyrosine-protein kinase JAK3 0.1 0.0 0.6 0.0 0.0 0.1 3.3 0.0 2.0 8.4 2.2 2.7 0.0 20.0
Kalrn kalirin 0.0 0.1 0.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2
Kdr vascular endothelial growth factor receptor 2 precursor 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.5 0.0 0.0 0.0 0.0
Kit mast/stem cell growth factor receptor precursor 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 5.8 4.9 0.1 0.5
Ksr1 kinase suppressor of Ras 1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Lats1 serine/threonine-protein kinase LATS1 0.0 0.1 0.0 0.0 0.0 1.8 0.1 0.0 0.3 0.1 3.4 1.1 0.0 1.3
Lats2 serine/threonine-protein kinase LATS2 0.0 2.3 0.0 7.1 0.0 36.1 26.1 0.0 0.8 0.1 3.9 3.0 0.0 3.1
Lck proto-oncogene tyrosine-protein kinase LCK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Limk1 LIM domain kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Limk2 LIM domain kinase 2 0.1 0.0 0.0 0.4 0.0 2.0 2.7 0.0 2.2 3.8 1.4 5.2 0.0 6.2
Lmtk2 serine/threonine-protein kinase LMTK2 precursor 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7
Lrrk1 leucine-rich repeat serine/threonine-protein kinase 1 0.0 0.0 0.1 4.6 0.1 4.4 0.3 0.0 0.5 1.7 0.4 2.0 0.1 9.1
Lrrk2 leucine-rich repeat serine/threonine-protein kinase 2 0.0 0.0 0.0 0.0 2.3 1.8 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0
Ltk leukocyte tyrosine kinase receptor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Lyn tyrosine-protein kinase Lyn isoform B 0.0 0.2 0.0 2.8 0.0 1.4 11.1 0.0 5.9 4.5 1.9 5.8 0.0 7.4
Mak serine/threonine-protein kinase MAK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Map2k1 dual specificity mitogen-activated protein kinase kinase 1 0.1 7.1 0.1 19.7 43.7 42.2 7.3 0.3 7.2 6.8 17.3 15.1 0.2 45.8
Map2k2 dual specificity mitogen-activated protein kinase kinase 2 91.7 58.5 33.1 60.0 15.1 33.7 14.8 18.5 61.5 61.3 22.7 51.9 24.7 17.1
Map2k3 mitogen activated protein kinase kinase 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Map2k4 dual specificity mitogen-activated protein kinase kinase 4 0.3 4.1 0.0 0.3 0.0 2.5 0.0 0.0 3.4 1.1 0.4 8.0 0.1 8.6
Map2k5 dual specificity mitogen-activated protein kinase kinase 5 isoform a 4.1 3.1 2.0 4.5 0.0 3.7 1.8 0.8 2.4 3.4 1.5 3.1 0.0 0.7
Map2k6 dual specificity mitogen-activated protein kinase kinase 6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Map2k7 dual specificity mitogen-activated protein kinase kinase 7 1.0 0.7 0.0 0.0 0.1 4.7 3.8 0.1 9.5 9.5 3.7 12.3 0.0 1.4
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Map3k10 mitogen-activated protein kinase kinase kinase 10 isoform X1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 1.2 0.0 0.5 0.0 0.0
Map3k11 mitogen-activated protein kinase kinase kinase 11 0.0 8.0 0.6 0.2 0.2 1.6 5.3 0.1 2.6 6.0 0.3 2.8 0.1 0.5
Map3k12 mitogen-activated protein kinase kinase kinase 12 21.0 3.7 6.1 8.2 9.6 15.5 16.2 7.3 4.3 12.2 8.3 20.6 6.1 10.8
Map3k13 mitogen-activated protein kinase kinase kinase 13 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.0 0.0 0.0 0.0 0.0 4.9 0.1 0.0 2.7 0.0 0.0 0.0 0.0 0.5
Map3k2 mitogen-activated protein kinase kinase kinase 2 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.0 0.6 0.1 2.7 0.1 0.2 4.0 0.0 4.4 6.3 6.1 5.7 0.0 4.8
Map3k4 mitogen-activated protein kinase kinase kinase 4 0.1 0.0 0.0 0.1 0.0 0.9 0.0 0.0 0.7 0.1 0.1 0.4 0.0 0.4
Map3k5 mitogen-activated protein kinase kinase kinase 5 0.4 0.1 0.0 0.0 0.0 4.8 0.2 0.0 0.3 0.0 0.1 0.2 0.0 0.3
Map3k6 mitogen-activated protein kinase kinase kinase 6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Map3k7 mitogen-activated protein kinase kinase kinase 7 57.6 30.6 0.0 0.0 0.0 696.2 0.0 206.1 550.5 1423.5 920.7 1323.0 0.0 191.0
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.0 0.0 0.0 0.0 0.0 31.6 3.9 0.0 0.0 0.0 0.0 0.0 0.0 1.7
Map3k9 mitogen-activated protein kinase kinase kinase 9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.0 0.2
Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.5 1.3 0.0 1.2 0.0 1.4
Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 0.0 0.0 0.0 0.0 0.0 1.7 0.7 0.0 0.3 0.9 0.0 1.6 0.0 4.5
Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 0.0 0.0 0.1 8.7 0.9 45.3 4.0 0.6 4.4 6.2 12.0 9.3 4.8 2.1
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.2 1.6 5.5 2.0 1.4
Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 0.0 0.0 0.0 0.2 0.1 14.1 21.8 0.0 1.5 0.0 3.4 3.7 0.0 9.1
Mapk1 mitogen-activated protein kinase 1 0.5 3.3 0.4 0.9 0.7 12.8 14.6 0.0 5.1 1.3 9.2 6.1 0.6 10.2
Mapk10 mitogen-activated protein kinase 10 isoform 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mapk11 mitogen-activated protein kinase 11 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mapk12 mitogen-activated protein kinase 12 0.6 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0
Mapk13 mitogen-activated protein kinase 13 0.1 0.0 0.0 0.7 0.0 3.6 0.8 0.1 8.9 17.1 10.5 20.8 0.0 15.4
Mapk14 mitogen-activated protein kinase 14 9.7 35.1 0.9 23.2 0.7 38.9 15.2 11.3 12.5 13.5 19.5 13.5 8.6 25.9
Mapk15 mitogen-activated protein kinase 15 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mapk3 mitogen-activated protein kinase 3 2.9 4.1 42.8 76.0 3.0 29.6 117.1 10.7 18.4 16.1 48.5 75.0 22.5 161.2
Mapk4 mitogen-activated protein kinase 4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mapk6 mitogen-activated protein kinase 6 0.1 3.0 0.0 5.4 1.2 16.1 0.1 0.0 0.7 0.8 0.3 1.9 0.0 10.6
Mapk7 mitogen-activated protein kinase 7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mapk8 mitogen-activated protein kinase 8 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.4 0.0 0.3 0.3 0.0 0.0
Mapk9 mitogen-activated protein kinase 9 isoform 3 0.7 0.0 0.0 0.7 0.6 5.9 13.1 0.1 1.5 1.0 1.5 3.2 0.0 1.9
Mapkapk2 MAP kinase-activated protein kinase 2 5.5 28.3 17.1 17.8 16.8 51.7 18.3 0.3 18.5 18.5 20.8 30.2 1.9 47.7
Mapkapk3 MAP kinase-activated protein kinase 3 0.5 0.5 0.2 0.2 0.0 4.1 0.0 0.0 1.4 0.3 13.8 15.2 0.3 2.2
Mapkapk5 MAP kinase-activated protein kinase 5 isoform 1 0.2 20.0 0.2 0.1 0.3 9.2 14.4 0.0 4.1 4.9 7.2 8.5 0.1 16.8
Mark1 serine/threonine-protein kinase MARK1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.0 0.0 2.2 0.1 0.0
Mark2 serine/threonine-protein kinase MARK2 0.9 2.6 0.3 0.4 0.0 2.4 1.3 1.2 1.4 3.1 4.1 6.0 2.2 6.3
Mark3 MAP/microtubule affinity-regulating kinase 3 3.0 9.4 0.1 0.1 2.4 19.1 0.0 1.4 9.6 2.9 3.5 1.3 0.5 2.9
Mark4 MAP/microtubule affinity-regulating kinase 4 0.0 0.0 0.0 0.0 0.0 0.4 1.2 0.0 0.5 1.2 0.1 0.7 0.0 1.0
MAST1 microtubule-associated serine/threonine-protein kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mast2 microtubule-associated serine/threonine-protein kinase 2 1.2 0.4 0.7 0.2 0.0 3.2 4.3 0.0 1.5 0.6 1.1 1.2 0.0 5.7
Mast3 microtubule-associated serine/threonine-protein kinase 3 0.1 1.7 0.0 0.0 0.0 2.5 0.1 0.0 0.8 2.3 1.3 1.9 0.0 2.5
Mastl microtubule-associated serine/threonine-protein kinase-like 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Matk megakaryocyte-associated tyrosine-protein kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Melk maternal embryonic leucine zipper kinase 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0
Mertk tyrosine-protein kinase Mer precursor 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Met hepatocyte growth factor receptor precursor 1.2 0.1 1.1 1.9 25.1 34.0 5.9 1.1 4.4 3.8 4.3 1.2 11.3 10.2
Mink1 misshapen-like kinase 1 1.7 2.5 0.3 0.1 0.2 0.8 0.6 0.2 1.6 6.7 2.9 1.5 0.0 3.8
Mknk1 MAP kinase-interacting serine/threonine-protein kinase 1 0.0 0.0 0.0 0.6 0.0 1.9 2.6 0.0 0.5 0.4 0.0 1.1 0.0 0.0
Mknk2 MAP kinase-interacting serine/threonine-protein kinase 2 2.2 2.7 11.9 36.1 12.5 17.9 46.8 0.1 6.9 9.6 1.9 10.3 4.0 45.1
Mok MAPK/MAK/MRK overlapping kinase 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.8 3.3 0.0 2.9 0.0 1.3
Mos proto-oncogene serine/threonine-protein kinase mos 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mst1r macrophage-stimulating protein receptor precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mst4 serine/threonine-protein kinase MST4 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.4 0.0 0.0 0.0 0.0 3.5
Mtor serine/threonine-protein kinase mTOR 0.4 0.3 0.0 0.0 0.0 1.0 0.1 0.0 0.9 0.4 0.6 1.8 0.8 3.7
Musk muscle, skeletal receptor tyrosine protein kinase precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mylk myosin light chain kinase, smooth muscle 0.1 0.5 0.0 0.1 0.0 0.0 0.2 0.0 2.3 0.0 0.0 0.0 0.0 0.1
Mylk2 myosin light chain kinase 2, skeletal/cardiac muscle 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Mylk3 myosin light chain kinase 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Myo3b myosin-IIIb 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 1.1 1.2 0.0 2.9
Nek1 serine/threonine-protein kinase Nek1 isoform X2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.2 0.2 0.0 0.2
Nek11 serine/threonine-protein kinase Nek11 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Nek2 serine/threonine-protein kinase Nek2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Nek4 serine/threonine-protein kinase Nek4 0.0 0.0 0.3 0.0 0.0 0.5 0.0 0.0 1.0 0.1 0.7 1.4 0.0 0.8
Nek6 serine/threonine-protein kinase Nek6 0.0 0.0 0.1 0.0 0.0 0.1 9.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0
Nek7 serine/threonine-protein kinase Nek7 0.1 0.3 0.1 0.4 1.8 8.4 2.2 3.5 1.0 2.8 9.0 7.1 0.2 6.8
Nek8 serine/threonine-protein kinase Nek8 1.1 7.5 0.0 0.0 0.0 0.1 0.1 0.0 4.6 2.7 1.6 5.6 0.0 0.5
Nek9 serine/threonine-protein kinase Nek9 2.2 3.7 0.5 2.5 16.8 7.6 22.8 4.8 5.2 6.5 6.2 9.4 4.7 10.0
Nlk serine/threonine-protein kinase NLK isoform X2 6.4 1.4 0.3 2.4 3.0 5.6 3.0 0.8 3.0 1.5 4.9 5.6 0.7 3.6
Npr1 atrial natriuretic peptide receptor 1 precursor 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1
Npr2 atrial natriuretic peptide receptor 2 precursor 0.0 0.0 0.0 0.5 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Nrbp1 nuclear receptor binding protein 1 18.1 26.2 7.9 18.8 1.0 18.2 1.1 0.7 20.8 27.1 15.1 25.7 10.5 44.7
Nrbp2 nuclear receptor-binding protein 2 0.0 0.0 0.0 0.1 0.0 4.5 5.3 0.0 4.0 11.1 0.1 5.4 0.0 4.5
Nrk nik-related protein kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ntrk1 high affinity nerve growth factor receptor precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 4.6 0.0 0.0
Ntrk2 BDNF/NT-3 growth factors receptor isoform 2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ntrk3 NT-3 growth factor receptor isoform 1 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Nuak1 NUAK family SNF1-like kinase 1 0.0 0.0 0.0 0.0 0.0 2.7 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.2
Nuak2 NUAK family SNF1-like kinase 2 6.2 28.7 0.2 18.3 17.7 65.0 1.5 5.1 23.8 21.6 14.1 24.1 1.5 3.4
Oxsr1 serine/threonine-protein kinase OSR1 0.2 0.3 0.0 0.6 0.1 10.5 3.6 0.2 2.3 2.3 8.4 2.2 1.0 6.3
Pak1 serine/threonine-protein kinase PAK 1 0.3 1.4 0.0 0.0 1.0 1.7 0.0 0.1 1.1 4.6 0.2 0.1 0.0 2.9
Pak2 serine/threonine-protein kinase PAK 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pak3 serine/threonine-protein kinase PAK 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pak4 serine/threonine-protein kinase PAK 4 1.0 1.3 0.5 0.5 7.1 12.9 3.6 0.4 5.3 10.2 17.4 39.7 16.9 2.5
Pak6 serine/threonine-protein kinase PAK 6 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 5.5 3.9 17.1 18.6 0.1 11.9
Pak7 serine/threonine-protein kinase PAK 7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pask PAS domain-containing serine/threonine-protein kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pbk PDZ binding kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0
Pdgfra platelet-derived growth factor receptor alpha precursor 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pdgfrb platelet-derived growth factor receptor beta precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pdik1l serine/threonine-protein kinase PDIK1L 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 1.3 0.0 0.0 0.0
Pdk1 pyruvate dehydrogenase kinase, isozyme 1 precursor 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 6.0 0.3 1.2 0.6 0.9
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 60.8 130.4 107.5 95.2 51.4 42.2 7.8 64.1 55.3 126.7 40.7 92.9 50.2 26.5
Pdk3 pyruvate dehydrogenase kinase, isozyme 3 1.9 1.9 0.0 0.1 0.0 16.0 4.7 0.9 4.4 8.6 3.0 10.5 15.6 13.0
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0
Pdpk1 3-phosphoinositide-dependent protein kinase 1 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.9 0.1 0.0 1.7 0.0 0.2
Peak1 pseudopodium-enriched atypical kinase 1 0.0 0.0 0.0 0.2 0.0 3.1 0.0 0.0 0.2 0.0 0.0 0.1 0.0 4.8
Phkg1 phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.7 0.8 0.0 0.2 0.0 0.4 0.0 0.0 3.3 4.7 2.4 2.5 0.0 2.0
Phkg2 phosphorylase b kinase gamma catalytic chain, liver/testis isoform 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0.0 0.8 0.1 0.7 0.0 6.0 3.1 0.7 2.1 0.1 0.8 1.4 0.2 1.4
Pik3r4 phosphoinositide 3-kinase regulatory subunit 4 2.1 0.1 0.3 0.9 0.0 9.9 0.1 1.3 7.4 4.2 0.0 1.6 0.0 4.4
Pim1 serine/threonine-protein kinase pim-1 0.0 0.0 0.0 0.0 0.0 1.1 0.1 0.0 0.0 1.1 0.1 1.4 2.5 3.6
Pim2 serine/threonine-protein kinase pim-2 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.6 0.8 0.0 4.0 0.0 2.2
Pim3 serine/threonine-protein kinase pim-3 0.3 1.4 36.8 23.9 7.0 104.1 149.4 35.5 28.7 13.3 33.5 55.8 49.6 66.0
Pink1 serine/threonine-protein kinase PINK1, mitochondrial 18.8 41.4 16.9 1.8 2.8 7.7 0.9 8.0 26.5 52.6 23.2 17.0 5.9 4.3
Pkdcc protein kinase domain-containing protein, cytoplasmic 0.0 0.1 0.0 0.0 0.0 0.0 13.0 1.3 16.5 0.1 0.2 3.7 0.1 0.0
Pkmyt1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.7
Pkn1 serine/threonine-protein kinase N1 0.9 5.1 0.4 7.5 7.3 5.8 13.3 0.1 5.3 8.9 7.2 16.0 11.1 12.3
Pkn2 serine/threonine-protein kinase N2 0.1 0.0 0.1 0.0 0.0 16.2 0.1 0.2 0.2 0.1 0.0 2.9 0.2 4.4
Pkn3 serine/threonine-protein kinase N3 isoform X5 0.1 0.1 0.1 0.0 0.0 0.7 0.0 0.0 0.5 0.1 0.1 0.3 0.0 0.5
Plk1 serine/threonine-protein kinase PLK1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0
Plk2 serine/threonine-protein kinase PLK2 0.0 0.0 0.0 0.0 0.0 1.5 4.0 0.0 0.0 0.0 0.0 0.0 0.0 9.3
Plk3 serine/threonine-protein kinase PLK3 0.0 0.0 0.0 0.0 0.0 12.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 63.5
Plk4 serine/threonine-protein kinase PLK4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1
Plk5 serine/threonine-protein kinase PLK5 0.0 0.0 0.0 0.0 0.0 2.9 0.2 0.1 0.2 0.0 0.0 0.3 0.0 17.2
Pnck calcium/calmodulin-dependent protein kinase type 1B 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Pomk protein O-mannose kinase 2.1 0.3 0.1 9.8 0.1 0.7 0.1 0.1 5.7 7.7 2.6 8.4 3.2 8.8
Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 0.0 0.0 0.0 0.1 0.9 0.7 0.1 0.0 1.1 2.2 4.6 1.2 0.0 1.7
Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Prkaca cAMP-dependent protein kinase catalytic subunit alpha 0.2 0.3 0.1 0.8 0.1 2.7 2.5 0.3 3.9 3.1 6.0 5.6 1.0 2.1
Prkacb cAMP-dependent protein kinase catalytic subunit beta 0.0 1.0 0.1 2.3 0.4 5.8 12.7 0.0 6.5 2.6 6.8 11.1 6.3 7.0
Prkca protein kinase C alpha type 0.5 0.1 0.1 0.0 0.7 2.7 0.0 0.0 1.0 0.2 0.0 0.0 0.0 0.1
Prkcb protein kinase C beta type isoform 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Prkcd protein kinase C delta type 0.1 4.0 0.0 0.2 0.0 5.6 0.1 1.3 2.2 2.0 3.1 16.4 0.2 2.2
Prkce protein kinase C epsilon type 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.7
Prkcg protein kinase C gamma type 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Prkch protein kinase C eta type 0.2 0.1 0.0 0.0 0.0 13.9 6.6 0.0 0.2 0.1 0.0 0.0 0.0 0.0
Prkci protein kinase C iota type 0.1 0.1 0.0 4.2 0.2 39.0 5.0 0.0 0.8 0.1 6.4 3.2 0.0 0.3
Prkcq protein kinase C theta type 0.0 0.1 0.2 11.4 12.2 14.5 4.5 0.8 4.3 0.8 0.1 0.1 0.1 0.0
Prkcz protein kinase C zeta type 4.0 0.0 0.0 2.4 1.1 15.8 0.3 0.3 11.2 10.2 9.8 14.2 5.0 19.3
Prkd1 serine/threonine-protein kinase D1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 5.2 0.9 0.0 0.0 0.0 0.1
Prkd2 serine/threonine-protein kinase D2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.5 0.0 1.0 0.0 0.9
Prkd3 serine/threonine-protein kinase D3 0.0 0.0 0.0 0.0 0.0 6.0 3.1 0.0 0.1 0.0 0.1 0.2 0.0 4.9
Prkg1 cGMP-dependent protein kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Prkg2 cGMP-dependent protein kinase 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Prkx serine/threonine-protein kinase PRKX 0.0 0.0 0.6 0.1 1.0 10.0 2.4 2.3 1.2 2.0 4.8 5.5 0.0 7.7
Prpf4b serine/threonine-protein kinase PRP4 homolog 0.5 1.7 0.2 0.3 12.5 30.5 4.5 0.0 1.6 0.3 2.2 8.3 0.1 11.2
Pskh1 protein serine kinase H1 1.5 3.2 0.2 31.2 1.3 35.3 1.5 1.9 16.9 20.3 18.8 23.9 21.2 35.1
Ptk2 focal adhesion kinase 1 5.5 0.5 0.4 0.8 0.0 9.3 4.6 0.0 2.6 5.7 2.6 5.4 1.0 3.9
Ptk2b protein-tyrosine kinase 2-beta 0.7 0.7 0.5 0.0 0.0 0.0 0.0 0.0 2.9 0.5 1.8 2.3 0.0 0.6
Ptk6 protein-tyrosine kinase 6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ptk7 tyrosine-protein kinase-like 7 0.0 0.0 0.0 0.0 0.0 1.0 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.9
Pxk PX domain-containing protein kinase-like protein 7.3 6.8 8.5 34.8 16.9 43.5 15.4 7.6 1.6 12.5 9.0 12.0 16.9 16.9
Raf1 RAF proto-oncogene serine/threonine-protein kinase 0.8 2.7 0.4 6.1 13.6 16.0 10.5 1.8 2.8 4.4 16.7 9.2 0.3 18.7
Ret proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Riok1 serine/threonine-protein kinase RIO1 0.1 0.8 0.3 0.2 0.0 3.3 0.2 0.3 3.4 0.1 1.4 2.3 0.2 5.3
Riok2 serine/threonine-protein kinase RIO2 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 3.7 0.2 0.1 9.2 0.0 2.4
Riok3 serine/threonine-protein kinase RIO3 3.0 14.7 4.1 0.4 0.7 2.6 13.4 0.2 3.0 9.2 31.6 17.3 13.0 6.2
Ripk1 receptor-interacting serine/threonine-protein kinase 1 0.0 0.1 0.0 0.0 0.0 1.1 4.0 0.0 0.2 0.1 0.0 0.3 0.0 0.3
Ripk2 receptor-interacting serine/threonine-protein kinase 2 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2
Ripk3 receptor-interacting serine/threonine-protein kinase 3 0.0 0.1 0.0 0.0 0.0 27.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 21.0
Ripk4 receptor-interacting serine/threonine-protein kinase 4 1.1 0.0 0.1 0.3 0.0 23.4 23.2 0.0 3.4 0.1 1.0 9.0 10.1 29.2
Rnasel 2-5A-dependent ribonuclease 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2
Rock1 rho-associated protein kinase 1 0.0 0.1 0.0 0.4 0.1 11.3 0.1 0.5 1.7 0.9 2.0 2.0 1.2 3.1
Rock2 rho-associated protein kinase 2 0.0 0.1 0.1 0.6 0.1 4.7 10.4 0.0 0.0 0.2 0.8 1.9 0.0 12.1
Ror1 tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ror2 tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.2 0.0 0.0 0.0 0.0
Ros1 proto-oncogene tyrosine-protein kinase ROS precursor 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.5 0.0 0.5
Rps6ka1 ribosomal protein S6 kinase alpha-1 2.8 12.3 2.1 1.8 18.1 15.1 2.8 0.1 3.5 5.3 6.7 12.5 0.1 9.4
Rps6ka2 ribosomal protein S6 kinase alpha-2 0.0 0.0 0.0 0.0 0.0 7.9 0.0 0.0 0.1 0.8 0.0 0.0 0.0 1.6
Rps6ka3 ribosomal protein S6 kinase alpha-3 isoform X4 0.2 2.6 0.2 0.0 0.0 34.1 8.2 0.0 1.8 0.6 6.6 3.3 1.3 6.5
Rps6ka4 ribosomal protein S6 kinase alpha-4 1.3 2.7 3.6 0.2 0.0 9.9 3.6 0.0 4.4 11.4 0.8 20.1 0.0 11.4
Rps6ka5 ribosomal protein S6 kinase alpha-5 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Rps6ka6 ribosomal protein S6 kinase alpha-6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0
Rps6kb1 ribosomal protein S6 kinase beta-1 0.0 0.0 0.0 1.0 0.0 9.8 2.4 0.0 0.5 0.1 0.7 0.8 0.0 0.4
Rps6kb2 ribosomal protein S6 kinase beta-2 0.0 16.6 8.9 10.9 0.0 8.3 3.3 0.0 8.7 4.5 2.0 13.7 0.1 12.0
Rps6kc1 ribosomal protein S6 kinase delta-1 0.0 0.1 0.0 0.0 0.0 4.9 0.0 0.0 3.2 0.1 2.1 1.9 0.0 3.9
Ryk tyrosine-protein kinase RYK precursor 1.4 0.2 0.1 0.1 1.6 19.3 22.2 0.2 6.3 7.5 9.2 9.4 0.3 30.0
Sbk1 serine/threonine-protein kinase SBK1 0.0 0.0 0.0 0.0 0.2 4.5 0.0 0.0 0.1 0.2 0.8 1.3 0.0 9.8
Sbk2 serine/threonine-protein kinase SBK2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Scyl1 N-terminal kinase-like protein 5.2 0.3 4.7 5.4 1.0 8.7 6.7 11.2 9.3 21.2 15.1 24.9 1.3 36.2
Scyl2 SCY1-like protein 2 0.0 1.2 0.0 0.0 0.1 4.2 0.2 0.0 0.6 2.7 3.3 1.3 0.0 5.3
Scyl3 protein-associating with the carboxyl-terminal domain of ezrin 0.0 0.2 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.5 0.5 0.0 0.1 0.2
Sgk1 serine/threonine-protein kinase Sgk1 isoform 2 14.4 30.7 17.8 5.1 0.5 42.0 15.9 2.7 2.9 18.5 91.8 98.9 222.5 315.4
Sgk2 serine/threonine-protein kinase Sgk2 5.5 8.7 0.0 0.0 0.0 0.0 0.1 0.0 6.6 3.7 0.1 0.0 0.0 0.0
Sik1 serine/threonine-protein kinase SIK1 0.0 0.0 0.0 2.3 0.1 16.2 6.7 0.0 0.1 0.1 0.0 0.7 0.0 6.1
Sik3 uncharacterized protein LOC684112 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.7 0.0 1.2 0.0 0.2
Slk STE20-like serine/threonine-protein kinase 0.0 0.1 0.0 3.0 1.4 2.0 8.6 0.0 1.5 0.4 0.1 0.8 0.0 1.5
Smok2a sperm motility kinase 2A 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Snrk SNF-related serine/threonine-protein kinase 0.2 0.0 0.0 1.9 0.1 3.5 0.5 0.1 2.1 0.6 1.3 3.8 0.0 0.8
Speg striated muscle-specific serine/threonine-protein kinase isoform 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Src proto-oncogene tyrosine-protein kinase Src 0.1 1.4 0.1 3.0 3.8 11.7 2.7 0.0 2.8 1.5 8.7 15.6 0.2 17.6
Srms tyrosine-protein kinase Srms 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Srpk1 serine/threonine-protein kinase SRPK1 0.1 0.1 0.0 2.9 0.0 7.7 5.1 0.0 6.6 6.7 1.8 8.4 1.6 3.7
Srpk2 serine/threonine-protein kinase SRPK2 0.1 0.5 0.0 0.0 0.0 10.1 0.1 0.0 9.0 3.8 7.5 13.8 0.7 4.2
Srpk3 serine/threonine-protein kinase SRPK3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Stk10 serine/threonine-protein kinase 10 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1
Stk11 serine/threonine-protein kinase STK11 0.5 0.6 0.9 0.2 0.6 5.3 0.5 0.0 6.1 3.5 1.1 2.6 0.0 3.7
Stk16 serine/threonine-protein kinase 16 28.1 5.1 0.1 11.0 0.3 4.0 2.2 0.1 37.4 62.0 59.7 30.2 0.2 15.8
Stk17b serine/threonine-protein kinase 17B 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.7 2.9 3.4 0.0 0.0 0.0 1.5
Stk24 serine/threonine-protein kinase 24 12.3 0.7 0.7 1.0 8.4 16.9 0.1 0.0 2.2 7.5 6.0 12.2 0.1 16.0
Stk25 serine/threonine-protein kinase 25 4.4 6.4 8.8 0.3 8.0 39.1 26.3 5.0 9.7 12.1 14.0 9.9 8.2 22.3
Stk3 serine/threonine-protein kinase 3 0.3 0.1 0.0 22.7 0.1 23.3 0.5 0.0 1.5 3.6 6.8 8.5 0.0 8.0
Stk31 serine/threonine-protein kinase 31 isoform X1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Stk32a serine/threonine-protein kinase 32A 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0
Stk32b serine/threonine-protein kinase 32B 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 7.8 0.3 0.1 3.2 0.0 0.0
Stk32c serine/threonine-protein kinase 32C 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Stk35 serine/threonine-protein kinase 35 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.1 0.1 1.0 0.2 0.0 0.3
Stk36 serine/threonine kinase 36 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Stk38 serine/threonine-protein kinase 38 0.6 0.8 0.2 13.6 20.7 14.5 0.3 0.0 4.3 1.7 7.1 14.4 0.0 15.4
Stk38l serine/threonine-protein kinase 38-like 0.2 1.3 0.1 0.3 0.1 7.1 3.3 0.2 3.3 0.7 4.8 3.7 0.0 3.6
Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 0.1 0.0 0.2 0.4 19.4 13.7 15.1 2.9 5.0 18.4 6.7 3.3 9.7 7.8
Stk4 serine/threonine-protein kinase 4 0.0 0.0 0.1 0.0 0.0 1.6 0.1 0.0 0.2 0.8 0.6 2.2 0.0 1.6
Stk40 serine/threonine-protein kinase 40 0.1 0.7 0.0 1.5 0.0 2.5 5.0 0.0 14.1 15.1 5.3 3.2 0.0 2.3
Strada STE20-related kinase adapter protein alpha 0.4 0.0 2.6 1.2 0.1 6.5 1.4 0.1 11.6 5.8 1.9 12.3 0.0 5.1
Stradb polyploidy associated protein kinase PAPK-A 5.7 2.5 8.0 31.3 29.8 33.3 0.9 0.1 5.9 13.7 14.8 8.6 0.0 23.8
Syk tyrosine-protein kinase SYK 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0
Taok1 serine/threonine-protein kinase TAO1 3.3 0.4 0.1 0.0 0.0 4.0 0.1 0.1 5.2 0.9 2.4 2.5 0.1 2.7
Taok2 serine/threonine-protein kinase TAO2 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 1.9 1.1 0.0 10.6 0.0 1.2
Taok3 serine/threonine-protein kinase TAO3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.4 1.1 0.0 0.5
Tbck TBC domain-containing protein kinase-like protein 0.0 1.0 0.0 0.0 0.0 7.9 0.0 0.0 0.1 0.0 0.8 0.3 0.0 0.0
Tbk1 serine/threonine-protein kinase TBK1 0.0 0.1 0.0 0.4 0.0 10.4 0.1 0.1 1.3 1.9 8.8 1.9 0.3 7.3
Tec tyrosine-protein kinase Tec 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1
Tek angiopoietin-1 receptor 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0
Tesk1 dual specificity testis-specific protein kinase 1 0.4 7.4 1.4 0.3 5.5 11.8 6.3 3.0 8.2 11.5 6.9 5.8 0.0 6.2
Tesk2 dual specificity testis-specific protein kinase 2 0.0 0.4 0.0 0.1 0.0 0.1 0.1 0.0 0.4 0.0 0.2 0.1 0.0 1.0
Tgfbr1 TGF-beta receptor type-1 precursor 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2
Tgfbr2 TGF-beta receptor type-2 precursor 2.8 1.0 0.1 62.5 104.4 17.3 44.8 0.1 8.2 12.1 1.4 1.4 0.0 11.3
Tie1 tyrosine-protein kinase receptor Tie-1 precursor 1.7 0.1 0.1 0.2 0.0 0.0 0.1 0.0 2.6 2.1 0.0 2.5 0.0 0.0
Tlk1 serine/threonine-protein kinase tousled-like 1 0.2 7.9 0.1 0.1 2.3 6.7 15.1 2.6 7.7 3.6 1.3 10.8 0.1 11.0
Tlk2 tousled-like kinase 2 isoform X8 0.2 0.1 0.0 0.0 0.0 3.0 0.0 0.0 3.3 3.6 2.4 5.0 0.1 3.0
Tnik Traf2 and NCK interacting kinase 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6
Tnk1 non-receptor tyrosine-protein kinase TNK1 0.1 0.0 0.0 0.2 0.0 12.2 0.2 0.3 1.3 0.6 0.1 14.3 0.0 10.2
Tnk2 activated CDC42 kinase 1 0.2 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.6 1.0 0.0 1.7 0.0 0.1
Tnni3k serine/threonine-protein kinase TNNI3K 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tp53rk TP53-regulating kinase 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.3 0.1 0.0 0.0
Trib1 tribbles homolog 1 1.9 0.8 0.0 0.1 0.0 0.6 0.2 0.0 2.6 0.9 1.3 0.7 0.0 4.5
Trib2 tribbles pseudokinase 2 0.1 12.5 0.4 0.0 0.0 0.0 0.1 8.1 4.0 7.6 0.1 0.0 0.1 0.0
Trib3 tribbles homolog 3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 3.2
Trpm7 transient receptor potential cation channel subfamily M member 7 0.1 0.3 0.0 0.0 0.0 1.8 1.8 0.0 1.2 4.0 1.4 1.7 0.6 1.6
Tssk1b testis-specific serine/threonine-protein kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tssk2 testis-specific serine/threonine-protein kinase 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tssk3 testis-specific serine/threonine-protein kinase 3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tssk4 testis-specific serine/threonine-protein kinase 4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tssk5 testis-specific serine/threonine-protein kinase 5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Tssk6 testis-specific serine/threonine-protein kinase 6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ttbk1 tau-tubulin kinase 1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ttbk2 tau-tubulin kinase 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ttk dual specificity protein kinase TTK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Txk tyrosine-protein kinase TXK 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 31.3 8.5 0.0
Tyk2 non-receptor tyrosine-protein kinase TYK2 0.0 0.0 0.0 0.0 0.0 1.1 0.5 0.0 0.8 0.3 0.8 1.4 0.0 12.0
Tyro3 tyrosine-protein kinase receptor TYRO3 precursor 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.2 1.6 2.2 0.3 0.0 12.9
Uhmk1 serine/threonine-protein kinase Kist 0.5 3.8 0.2 8.2 17.0 18.5 19.8 0.5 6.6 6.8 9.0 10.2 0.1 27.6
Ulk1 serine/threonine-protein kinase ULK1 0.0 0.0 0.0 0.2 0.3 24.6 22.9 0.1 4.0 5.3 7.6 12.1 9.3 22.3
Ulk2 serine/threonine-protein kinase ULK2 isoform X3 0.0 2.2 0.3 3.5 0.1 5.6 0.0 0.0 0.1 0.8 3.1 0.2 0.0 3.3
Ulk3 serine/threonine-protein kinase ULK3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 1.2
Vrk1 serine/threonine-protein kinase VRK1 0.0 0.0 0.0 0.1 0.0 6.9 0.1 0.0 6.5 0.2 3.3 3.0 0.0 0.4
Vrk2 serine/threonine-protein kinase VRK2 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Vrk3 serine/threonine-protein kinase VRK3 4.7 0.5 2.8 0.4 9.0 9.8 0.1 0.1 9.9 9.9 8.8 9.6 0.1 2.3
Wee1 wee1-like protein kinase 0.2 2.9 0.1 0.0 0.1 4.4 0.3 0.0 1.1 0.8 2.5 17.7 0.4 13.1
Wnk1 serine/threonine-protein kinase WNK1 isoform 3 3.9 0.6 0.1 7.3 4.4 4.4 7.4 1.0 44.5 182.2 41.4 9.8 0.6 3.9
Wnk2 serine/threonine-protein kinase WNK2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Wnk3 serine/threonine-protein kinase WNK3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Wnk4 serine/threonine-protein kinase WNK4 6.8 6.5 1.9 0.6 1.4 6.3 59.2 7.3 16.9 38.8 19.7 27.8 14.6 17.6
Yes1 tyrosine-protein kinase Yes 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2
Zap70 tyrosine-protein kinase ZAP-70 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
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Gene Symbol Description/Annotation S1 S2 S3 SDL LDLOM LDLIM tAL mTAL cTAL DCT CNT CCD OMCD IMCD