| Epithelial Systems Biology Laboratory, NHLBI, NIH | ||||
| Mouse Renal Inner Medullary Transcripts Increased or Decreased in Response to 7-Day Vasopressin Infusion | ||||
| Data from: Cai Q, McReynolds
MR, Keck M, Greer KA, Hoying JB, Brooks HL. Vasopressin
receptor subtype 2 activation
increases cell proliferation in the renal medulla of AQP1 null mice. Am J Physiol Renal Physiol. 2007; 293:F1858-64.
PMID: 17913837. Methods: AQP1 knockout mice were infused with the V2-selective vasopressin analog dDAVP via osmotic minipumps at 0.5 ng/h for 7 days. Controls received vehicle. RNA samples were isolated from individual mouse inner medullas. After reverse transcription and amplification the cDNAs obtained were fluorescently labeled using 546 Alexa Fluor and 647 Alexa Fluor for dDAVP/control pairs. Relative transcript levels were read out using cDNA arrays constructed using the National Institute on Aging mouse 15K clone set http://lgsun.grc.nia.nih.gov/cDNA/15k.html. (AQP1 knockout mice were used to prevent large changes in medullary osmolality which could have been a confounding factor. AQP1 is necessary for countercurrent multiplication.) Data are mean values from three pairs of samples from different mice. |
||||
| Database created by Heddwen Brooks (Dept. of Physiology, U. of Ariz.) and Mark Knepper (NHLBI). Email: brooksh@email.arizona.edu | ||||
| Database is hosted by the Epithelial Systems Biology Laboratory, National Heart, Lung and Blood Institute as part of its Kidney Systems Biology Project. | ||||
| Official | dDAVP-Infused | |||
| Gene Symbol | (percent of | Annotation | ||
| control) | ||||
| Abce1 | 161 | ATP-binding cassette sub-family E member 1 | ||
| Adamts1 | 243 | A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor | ||
| Adarb1 | 169 | double-stranded RNA-specific editase 1 isoform 1 | ||
| Ahsa1 | 205 | activator of 90 kDa heat shock protein ATPase homolog 1 | ||
| Akr1b3 | 27 | aldose reductase | ||
| Aldh7a1 | 66 | alpha-aminoadipic semialdehyde dehydrogenase isoform a | ||
| Ampd3 | 53 | AMP deaminase 3 | ||
| Apex1 | 203 | DNA-(apurinic or apyrimidinic site) lyase | ||
| Arg2 | 222 | arginase-2, mitochondrial precursor | ||
| Arpc1a | 65 | actin-related protein 2/3 complex subunit 1A | ||
| Arpc1a | 58 | actin-related protein 2/3 complex subunit 1A | ||
| Atf3 | 230 | cyclic AMP-dependent transcription factor ATF-3 | ||
| Atp2a2 | 56 | sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b | ||
| Bmi1 | 64 | polycomb complex protein BMI-1 | ||
| Bpgm | 56 | bisphosphoglycerate mutase | ||
| Cbfb | 151 | core-binding factor subunit beta isoform 4 | ||
| Ccdc3 | 41 | coiled-coil domain-containing protein 3 precursor | ||
| Ccdc80 | 261 | coiled-coil domain-containing protein 80 precursor | ||
| Ccnd1 | 335 | G1/S-specific cyclin-D1 | ||
| CCng1 | 165 | cyclin-G1 | ||
| Cd82 | 62 | CD82 antigen | ||
| Cdc42 | 167 | cell division control protein 42 homolog isoform 2 | ||
| Cdca5 | 151 | sororin | ||
| Cdk1 | 212 | cyclin-dependent kinase 1 | ||
| Cept1 | 56 | choline/ethanolaminephosphotransferase 1 | ||
| Cept1 | 47 | choline/ethanolaminephosphotransferase 1 | ||
| Chmp2a | 155 | charged multivesicular body protein 2a | ||
| Cirbp | 49 | cold-inducible RNA-binding protein | ||
| Cks1b | 242 | cyclin-dependent kinases regulatory subunit 1 | ||
| Cks2 | 168 | cyclin-dependent kinases regulatory subunit 2 | ||
| Clic4 | 162 | chloride intracellular channel protein 4 | ||
| Clu | 244 | clusterin precursor | ||
| Cntf | 160 | ciliary neurotrophic factor | ||
| Cox2 | 53 | cytochrome c oxidase subunit II (mitochondrion) | ||
| Cox4i1 | 60 | cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor | ||
| Crip2 | 67 | cysteine-rich protein 2 | ||
| Csad | 60 | cysteine sulfinic acid decarboxylase | ||
| Cxcl12 | 67 | stromal cell-derived factor 1 isoform gamma precursor | ||
| Cyhr1 | 63 | cysteine and histidine-rich protein 1 isoform 2 | ||
| Cytb | 55 | cytochrome b (mitochondrion) | ||
| Dap | 60 | death-associated protein 1 | ||
| Dbf4 | 163 | protein DBF4 homolog A isoform 2 | ||
| Dbf4 | 161 | protein DBF4 homolog A isoform 2 | ||
| Dbi | 54 | acyl-CoA-binding protein isoform 1 | ||
| Dcaf11 | 50 | DDB1- and CUL4-associated factor 11 | ||
| Dcxr | 59 | L-xylulose reductase | ||
| Ddost | 150 | dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor | ||
| Ddx1 | 57 | ATP-dependent RNA helicase DDX1 | ||
| Ddx3x | 63 | ATP-dependent RNA helicase DDX3X | ||
| Dgat1 | 63 | diacylglycerol O-acyltransferase 1 | ||
| Dhrs3 | 64 | short-chain dehydrogenase/reductase 3 isoform 2 | ||
| Dkk3 | 169 | dickkopf-related protein 3 precursor | ||
| Dus1l | 150 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like | ||
| Efhd1 | 42 | EF-hand domain-containing protein D1 | ||
| Efr3a | 58 | protein EFR3 homolog A | ||
| Egr1 | 893 | early growth response protein 1 | ||
| Ehd3 | 68 | EH domain-containing protein 3 | ||
| Epb4.1l4b | 44 | band 4.1-like protein 4B | ||
| Ephx1 | 47 | epoxide hydrolase 1 precursor | ||
| Eps8l2 | 58 | epidermal growth factor receptor kinase substrate 8-like protein 2 | ||
| Erdr1 | 60 | erythroid differentiation regulator 1 | ||
| Exoc3l2 | 53 | PREDICTED: exocyst complex component 3-like 2 | ||
| Exosc1 | 152 | exosome complex component CSL4 isoform 2 | ||
| Fam20c | 51 | extracellular serine/threonine protein kinase FAM20C precursor | ||
| Fbp2 | 395 | fructose-1,6-bisphosphatase isozyme 2 | ||
| Fkbp8 | 66 | peptidyl-prolyl cis-trans isomerase FKBP8 isoform a | ||
| Fubp1 | 66 | far upstream element-binding protein 1 | ||
| Gadd45g | 167 | growth arrest and DNA damage-inducible protein GADD45 gamma | ||
| Gm2a | 61 | ganglioside GM2 activator precursor | ||
| Gna14 | 67 | guanine nucleotide-binding protein subunit alpha-14 | ||
| Got2 | 66 | aspartate aminotransferase, mitochondrial | ||
| Gpx3 | 53 | glutathione peroxidase 3 precursor | ||
| Havcr1 | 238 | hepatitis A virus cellular receptor 1 homolog isoform a precursor | ||
| Hba-a1 | 67 | hemoglobin subunit alpha | ||
| Hba-a1 | 51 | hemoglobin subunit alpha | ||
| Hbb-y | 61 | hemoglobin subunit epsilon-Y2 | ||
| Hbb-y | 54 | hemoglobin subunit epsilon-Y2 | ||
| Hipk1 | 51 | homeodomain-interacting protein kinase 1 | ||
| Hn1 | 169 | hematological and neurological expressed 1 protein | ||
| Hnrnpd | 66 | heterogeneous nuclear ribonucleoprotein D0 isoform c | ||
| Hsd3b4 | 67 | 3 beta-hydroxysteroid dehydrogenase type 4 | ||
| Hsp90aa1 | 151 | heat shock protein HSP 90-alpha | ||
| Hspa14 | 66 | heat shock 70 kDa protein 14 isoform 1 | ||
| Hspa8 | 201 | heat shock cognate 71 kDa protein | ||
| Ilk | 60 | integrin-linked protein kinase | ||
| Itm2b | 58 | integral membrane protein 2B | ||
| Itm2c | 57 | integral membrane protein 2C | ||
| Jade1 | 62 | protein Jade-1 | ||
| Kif23 | 157 | kinesin-like protein KIF23 | ||
| Lbp | 56 | lipopolysaccharide-binding protein precursor | ||
| Lcmt1 | 158 | leucine carboxyl methyltransferase 1 | ||
| Lcn2 | 505 | neutrophil gelatinase-associated lipocalin precursor | ||
| Lenep | 156 | lens epithelial cell protein LEP503 | ||
| Lgals1 | 155 | galectin-1 | ||
| Lgals6 | 66 | galectin-6 | ||
| Ly6a | 51 | lymphocyte antigen 6A-2/6E-1 precursor | ||
| Ly6e | 41 | lymphocyte antigen 6E precursor | ||
| Mapk9 | 61 | mitogen-activated protein kinase 9 isoform alpha2 | ||
| March7 | 198 | E3 ubiquitin-protein ligase MARCH7 | ||
| Mat2b | 54 | methionine adenosyltransferase 2 subunit beta isoform 1 | ||
| Mcm6 | 150 | DNA replication licensing factor MCM6 | ||
| Mdk | 176 | midkine precursor | ||
| Mib1 | 155 | E3 ubiquitin-protein ligase MIB1 | ||
| Ms4a6d | 160 | membrane-spanning 4-domains subfamily A member 6D | ||
| Msl1 | 58 | male-specific lethal 1 homolog | ||
| Mt1 | 234 | metallothionein-1 | ||
| Mta3 | 61 | metastasis-associated protein MTA3 isoform 3 | ||
| Mtmr6 | 49 | myotubularin-related protein 6 | ||
| Muc1 | 45 | mucin-1 precursor | ||
| Myl6 | 152 | myosin light polypeptide 6 | ||
| Ndrg2 | 51 | protein NDRG2 isoform 1 | ||
| Ndrg4 | 29 | protein NDRG4 isoform B | ||
| Nek2 | 155 | serine/threonine-protein kinase Nek2 | ||
| Neo1 | 154 | neogenin isoform 2 precursor | ||
| Nhp2 | 161 | H/ACA ribonucleoprotein complex subunit 2 | ||
| Npc1 | 65 | Niemann-Pick C1 protein precursor | ||
| Npm1 | 183 | nucleophosmin isoform 3 | ||
| Pabpc1 | 234 | polyadenylate-binding protein 1 | ||
| Pabpc1 | 208 | polyadenylate-binding protein 1 | ||
| Pard3 | 60 | partitioning defective 3 homolog isoform 4 | ||
| Pdgfa | 57 | platelet-derived growth factor subunit A precursor | ||
| Pecr | 64 | peroxisomal trans-2-enoyl-CoA reductase | ||
| Pfkfb3 | 53 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 isoform X4 | ||
| Phtf1 | 61 | putative homeodomain transcription factor 1 isoform c | ||
| Plec | 150 | plectin isoform 1e | ||
| Plet1 | 210 | placenta-expressed transcript 1 protein precursor | ||
| Plin2 | 164 | perilipin-2 | ||
| Ppap2b | 167 | lipid phosphate phosphohydrolase 3 | ||
| Ppm1h | 162 | protein phosphatase 1H isoform 1 | ||
| Ppp2r4 | 62 | serine/threonine-protein phosphatase 2A activator | ||
| Pskh1 | 58 | serine/threonine-protein kinase H1 | ||
| Pthlh | 57 | parathyroid hormone-related protein preproprotein | ||
| Pttg1 | 67 | securin isoform 1 | ||
| Pttg1ip | 62 | pituitary tumor-transforming gene 1 protein-interacting protein precursor | ||
| Pygb | 61 | glycogen phosphorylase, brain form | ||
| Rcn1 | 224 | reticulocalbin-1 precursor | ||
| Rcn3 | 159 | reticulocalbin-3 precursor | ||
| RGD1308430 | 163 | uncharacterized protein | ||
| Rlim | 234 | E3 ubiquitin-protein ligase RLIM | ||
| Rnh1 | 172 | ribonuclease inhibitor isoform b | ||
| Rpl10a | 215 | 60S ribosomal protein L10a | ||
| Rpl13 | 201 | 60S ribosomal protein L13 | ||
| Rpl15 | 204 | 60S ribosomal protein L15 | ||
| Rpl15 | 166 | 60S ribosomal protein L15 | ||
| Rpl15 | 158 | 60S ribosomal protein L15 | ||
| Rpl18a | 163 | 60S ribosomal protein L18a | ||
| Rpl21 | 163 | 60S ribosomal protein L21 | ||
| Rpl23 | 158 | 60S ribosomal protein L23 | ||
| Rpl23 | 155 | 60S ribosomal protein L23 | ||
| Rpl26 | 167 | 60S ribosomal protein L26 | ||
| Rpl26 | 153 | 60S ribosomal protein L26 | ||
| Rpl28 | 165 | 60S ribosomal protein L28 | ||
| Rpl35a | 158 | 60S ribosomal protein L35a | ||
| Rpl38 | 154 | 60S ribosomal protein L38 | ||
| Rpl39 | 161 | 60S ribosomal protein L39 | ||
| Rpl4 | 272 | 60S ribosomal protein L4 | ||
| Rpl4 | 223 | 60S ribosomal protein L4 | ||
| Rps15 | 181 | 40S ribosomal protein S15 | ||
| Rps18 | 155 | 40S ribosomal protein S18 | ||
| Rps3a1 | 169 | 40S ribosomal protein S3a | ||
| Rps5 | 157 | 40S ribosomal protein S5 | ||
| Rras | 187 | ras-related protein R-Ras precursor | ||
| Rras | 183 | ras-related protein R-Ras precursor | ||
| Scml1 | 65 | sex comb on midleg-like protein 1 | ||
| Sde2 | 173 | protein SDE2 homolog | ||
| Sec31a | 60 | protein transport protein Sec31A | ||
| Sec61g | 157 | protein transport protein Sec61 subunit gamma isoform 1 | ||
| Sgk1 | 22 | serine/threonine-protein kinase Sgk1 isoform b | ||
| Slc31a2 | 59 | probable low affinity copper uptake protein 2 | ||
| Slc34a2 | 167 | sodium-dependent phosphate transport protein 2B | ||
| Slc44a1 | 40 | choline transporter-like protein 1 isoform B | ||
| Slc50a1 | 60 | sugar transporter SWEET1 | ||
| Specc1l | 63 | cytospin-A isoform b | ||
| Ssr3 | 158 | translocon-associated protein subunit gamma | ||
| Stk38 | 61 | serine/threonine-protein kinase 38 | ||
| Syf2 | 59 | pre-mRNA-splicing factor SYF2 | ||
| Tbc1d23 | 51 | TBC1 domain family member 23 | ||
| Tecr | 54 | very-long-chain enoyl-CoA reductase isoform 1 | ||
| Thra | 46 | thyroid hormone receptor alpha | ||
| Tkt | 187 | transketolase | ||
| Tmem234 | 169 | transmembrane protein 234 precursor | ||
| Tmem248 | 58 | transmembrane protein 248 | ||
| Tnfrsf23 | 158 | tumor necrosis factor receptor superfamily member 23 precursor | ||
| Tor1aip2 | 366 | torsin-1A-interacting protein 2 isoform b | ||
| Tpd52l1 | 55 | tumor protein D53 | ||
| Trp53 | 154 | cellular tumor antigen p53 isoform b | ||
| Tsc22d1 | 208 | TSC22 domain family protein 1 isoform 3 | ||
| Tsc22d4 | 65 | TSC22 domain family protein 4 isoform 1 | ||
| Tspan9 | 50 | tetraspanin-9 | ||
| Tubb5 | 212 | tubulin beta-5 chain | ||
| Ucp2 | 45 | mitochondrial uncoupling protein 2 | ||
| Ulk2 | 61 | serine/threonine-protein kinase ULK2 | ||
| Usp9x | 152 | probable ubiquitin carboxyl-terminal hydrolase FAF-X | ||
| Vamp8 | 67 | vesicle-associated membrane protein 8 | ||
| Vkorc1l1 | 166 | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3 | ||
| Zc3h11a | 58 | zinc finger CCCH domain-containing protein 11A | ||
| Zfand5 | 63 | AN1-type zinc finger protein 5 | ||
| Zfp36l1 | 66 | zinc finger protein 36, C3H1 type-like 1 | ||