Code Sharing and Supplemental Figures

Shahzad Sohail, Nipun U. Jayatissa, Ray Mejia, Shaza Khan, Chung-Lin Chou, Chin-Rang Yang and Mark A. Knepper

A Brief History of the Cortical Thick Ascending Limb: From the Isolated Perfused Tubule to 21st Century Systems Biology

PMID: Pending

Code Download: Click here for source code.

Supplemental Figures:

Supp Figure 1

Supp Figure 2

Supp Figure 3

Parameters:

P_osm = osmotic water permeability coefficient

P_salt = salt permeability coefficient

P_urea = urea permeability coefficient

s_salt = Staverman reflection coefficient for salt

s_urea = Staverman reflection coefficient for urea

L = length

D = diameter

C_salt (outside) = concentration of salt in fluid outside of the tubule

C_urea (outside) = concentration of urea in fluid outside of the tubule

K_m = Michaelis constant for salt

J_max = Active salt transport maximum

C_salt(0) = salt (NaCl) concentration at x=0

C_urea(0) = urea concentration at x=0

F_v(0) = axial volume flow rate at x=0

Variables:

C_salt = salt (NaCl) concentration

C_urea = urea concentration

F_v = axial volume flow rate

F_salt = axial salt flow rate [F_salt = F_v C_salt]

F_urea = axial urea flow rate [F_urea = F_v C_urea]

J_v = radial water flux across tubule epithelium

J_{salt =} radial salt flux across tubule epithelium

J_{urea =} radial urea flux across tubule epithelium