Proteins Expressed at Significantly Different Levels between ZT12 and ZT0 in Mouse Kidney

Method: Whole right kidney samples from mice were obtained at ZT12 (n=3) and ZT0 (n=3) and processed for quantitative protein mass spectrometry using tandem mass tagging (TMT) for quantification. ZT12 is Zeitgeber Time 12 (time at lights off in 12:12 hour scheme). ZT0 is Zeitgeber Time 0 (time at lights on in 12:12 hour scheme). Log2 (ZT12/ZT0) is the base 2 logarithm of the protein abundance ratio between ZT12 and ZT0. P-value is from t-statistic of log2(protein abundance) values from the 6 samples. This page reports only differences with Pjoint less than 0.0005 (see "Download Data" for calculation). LC-MS/MS was carried out in an Orbitrap Fusion Lumos mass spectrometer (Thermo Scientific).

This website was created by Molly Bingham, Chin-Rang Yang, and Mark Knepper (December 2022). Download data. Contact us with questions or comments: knep@helix.nih.gov.

For list of ZT12 vs. ZT0 values for all proteins, click here.

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Gene Symbol Annotation Log2 (ZT12/ZT0) P (t-test)
Obp1b odorant-binding protein 1b 1.0252 0.0161
Ccn2 CCN family member 2 0.8581 0.0041
Obp1a odorant-binding protein 1a 0.7690 0.0093
Gas2l1 GAS2-like protein 1 0.7297 0.0012
Scgb1b29 androgen-binding protein 0.6322 0.0335
Scgb2b2 secretoglobin family 2B member 2 0.5471 0.0142
Rps27 40S ribosomal protein S27 0.5036 0.0107
Arhgef10 rho guanine nucleotide exchange factor 10 0.4947 0.0101
mt-Co3 cytochrome c oxidase subunit 3 0.4887 0.0072
Errfi1 ERBB receptor feedback inhibitor 1 0.4856 0.0024
Elk4 ETS domain-containing protein Elk-4 0.4740 0.0052
F3 tissue factor 0.4710 0.0351
Anxa11 annexin A11 0.4694 0.0478
Anxa4 annexin A4 0.4559 0.0214
Cpne3 copine-3 0.4506 0.0142
Scgb1b3 androgen-binding protein 0.4399 0.0243
Gas1 growth arrest-specific protein 1 0.4052 0.0212
Hnrnpa2b1 heterogeneous nuclear ribonucleoproteins A2/B11 0.3869 0.0148
Guf1 translation factor GUF1, mitochondrial 0.3829 0.0082
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.3807 0.0071
Lrrc8d volume-regulated anion channel subunit LRRC8D 0.3740 0.0063
Herpud1 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein 0.3697 0.0008
Rbpms2 RNA-binding protein with multiple splicing 2 0.3661 0.0061
Ttf1 transcription termination factor 1 0.3515 0.0018
Rpl32-ps pseudogene 0.3449 0.0178
Abhd5 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 0.3395 0.0334
Noct nocturnin 0.3364 0.0079
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.3327 0.0146
Serpinb5 serpin B5 0.3259 0.0009
Hnrnpc heterogeneous nuclear ribonucleoproteins C1/C2 0.3254 0.0444
Rsrp1 arginine/serine-rich protein 1 0.3222 0.0215
Hdac4 histone deacetylase 4 0.3151 0.0490
Rnaset2b ribonuclease T2-B 0.3145 0.0192
Gabpa GA-binding protein alpha chain 0.3131 0.0197
Ociad2 OCIA domain-containing protein 2 0.3124 0.0178
Carnmt1 carnosine N-methyltransferase 0.3109 0.0318
Mcl1 induced myeloid leukemia cell differentiation protein Mcl-1 0.3103 0.0320
D6Wsu163e protein C12orf4 homolog 0.3035 0.0089
Lpin1 phosphatidate phosphatase LPIN1 0.3020 0.0068
Gm7324 null 0.3018 0.0277
Ms4a10 membrane-spanning 4-domains subfamily A member 10 0.2994 0.0044
Rbfox2 RNA binding protein fox-1 homolog 25 0.2961 0.0207
Samd4b protein Smaug homolog 2 0.2911 0.0074
Tmem72 transmembrane protein 72 0.2907 0.0008
Ppt1 palmitoyl-protein thioesterase 1 0.2904 0.0013
Gpm6a neuronal membrane glycoprotein M6-a 0.2870 0.0027
Cbx8 chromobox protein homolog 8 0.2865 0.0203
Usp3 ubiquitin carboxyl-terminal hydrolase 3 0.2858 0.0110
Pde3b cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B 0.2826 0.0032
Wee1 wee1-like protein kinase 0.2792 0.0489
Matr3 matrin-3 0.2787 0.0185
Pura transcriptional activator protein Pur-alpha 0.2783 0.0086
Ttr transthyretin 0.2771 0.0273
Ttc36 tetratricopeptide repeat protein 36 0.2747 0.0141
Rcc1 regulator of chromosome condensation 0.2727 0.0162
Gan gigaxonin 0.2726 0.0283
Slc35c2 solute carrier family 35 member C2 0.2699 0.0272
Rlim E3 ubiquitin-protein ligase RLIM 0.2660 0.0075
Rnase4 ribonuclease 4 0.2645 0.0178
Scn7a sodium channel protein type 7 subunit alpha 0.2628 0.0146
Ppil3 peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b 0.2576 0.0222
Necab1 N-terminal EF-hand calcium-binding protein 1 0.2569 0.0124
Ube2e1 ubiquitin-conjugating enzyme E2 E1 0.2549 0.0241
Ifitm3 interferon-induced transmembrane protein 3 0.2538 0.0067
Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.2533 0.0047
Slc2a5 solute carrier family 2, facilitated glucose transporter member 5 0.2527 0.0279
Kctd21 BTB/POZ domain-containing protein KCTD21 0.2505 0.0308
Diaph2 protein diaphanous homolog 256 0.2501 0.0006
C2 complement C2 0.2489 0.0273
Osbpl7 oxysterol-binding protein-related protein 7 0.2473 0.0021
Gtf2a1 transcription initiation factor IIA subunit 1 0.2472 0.0496
2200002D01Rik immortalization up-regulated protein 0.2454 0.0177
Yae1d1 protein YAE1 homolog 0.2429 0.0252
Commd4 COMM domain-containing protein 4 0.2401 0.0016
Ptprn2 receptor-type tyrosine-protein phosphatase N2 0.2396 0.0431
Bet1 BET1 homolog 0.2391 0.0150
Taf15 TATA-binding protein-associated factor 2N 0.2359 0.0030
Sarnp SAP domain-containing ribonucleoprotein 0.2347 0.0032
Pdxk pyridoxal kinase 0.2345 0.0258
Mrps36 alpha-ketoglutarate dehydrogenase component 4 0.2339 0.0196
Mfap1b microfibrillar-associated protein 1B 0.2333 0.0091
Fam120b constitutive coactivator of peroxisome proliferator-activated receptor gamma 0.2324 0.0062
Ncoa5 nuclear receptor coactivator 5 0.2316 0.0000
Ifih1 interferon-induced helicase C domain-containing protein 1 0.2298 0.0109
Dlgap4 disks large-associated protein 4 0.2288 0.0126
Stk10 serine/threonine-protein kinase 10 0.2285 0.0434
Map3k11 mitogen-activated protein kinase kinase kinase 11 0.2277 0.0342
Scrib protein scribble homolog 0.2273 0.0161
Eif4e2 eukaryotic translation initiation factor 4E type 2 0.2267 0.0220
Dcn decorin 0.2265 0.0212
Sox13 transcription factor SOX-13 0.2259 0.0434
Med31 mediator of RNA polymerase II transcription subunit 31 0.2258 0.0081
Ogdh 2-oxoglutarate dehydrogenase complex component E1 0.2250 0.0397
Bloc1s2 biogenesis of lysosome-related organelles complex 1 subunit 2 0.2240 0.0079
Trp53i11 tumor protein p53-inducible protein 11 0.2225 0.0329
Chac2 glutathione-specific gamma-glutamylcyclotransferase 2 0.2221 0.0185
Ssbp1 single-stranded DNA-binding protein, mitochondrial 0.2199 0.0288
Vars2 valine--tRNA ligase, mitochondrial 0.2198 0.0342
Pcbd2 pterin-4-alpha-carbinolamine dehydratase 2 0.2196 0.0301
Khdrbs1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0.2165 0.0008
Ice1 little elongation complex subunit 1 0.2163 0.0100
Spp1 osteopontin 0.2154 0.0483
Cytl1 cytokine-like protein 1 0.2151 0.0316
Mrpl40 39S ribosomal protein L40, mitochondrial 0.2144 0.0072
Fam234b protein FAM234B 0.2141 0.0171
Sqstm1 sequestosome-1 0.2126 0.0097
Mid1ip1 mid1-interacting protein 1 0.2122 0.0271
Ugt1a9 UDP-glucuronosyltransferase 1A9 0.2096 0.0000
Spryd7 SPRY domain-containing protein 7 0.2096 0.0475
Cisd3 CDGSH iron-sulfur domain-containing protein 3, mitochondrial 0.2088 0.0343
Suclg2 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial 0.2048 0.0304
Mcm10 protein MCM10 homolog 0.2047 0.0306
Qrich1 transcriptional regulator QRICH1 0.2046 0.0185
Hnrnpl heterogeneous nuclear ribonucleoprotein L 0.2044 0.0408
Papss2 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.2039 0.0024
Sts steryl-sulfatase 0.2023 0.0107
Tnc tenascin 0.2019 0.0469
Lama2 laminin subunit alpha-2 0.1996 0.0104
Mrps18b 28S ribosomal protein S18b, mitochondrial 0.1991 0.0143
Atp8a1 phospholipid-transporting ATPase IA 0.1987 0.0123
Fus RNA-binding protein FUS 0.1985 0.0077
Hnrnph1 heterogeneous nuclear ribonucleoprotein H 0.1983 0.0182
Pde6d retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 0.1980 0.0118
Keg1 glycine N-acyltransferase-like protein Keg1 0.1976 0.0067
Gabarapl1 gamma-aminobutyric acid receptor-associated protein-like 1 0.1969 0.0203
Eloc elongin-C 0.1969 0.0023
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 0.1958 0.0162
Ik protein Red 0.1944 0.0317
Ppa2 inorganic pyrophosphatase 2, mitochondrial 0.1931 0.0283
Zc3h14 zinc finger CCCH domain-containing protein 147 0.1926 0.0004
Lamtor4 ragulator complex protein LAMTOR4 0.1923 0.0006
Slc44a4 choline transporter-like protein 4 0.1901 0.0379
Tns2 tensin-2 0.1890 0.0378
Ngef ephexin-1 0.1885 0.0096
Hibch 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0.1880 0.0180
Tmem181a transmembrane protein 181 0.1859 0.0116
Prkra interferon-inducible double-stranded RNA-dependent protein kinase activator A 0.1853 0.0394
Cep68 centrosomal protein of 68 kDa 0.1849 0.0440
Col15a1 collagen alpha-1(XV) chain 0.1844 0.0448
Mogat1 2-acylglycerol O-acyltransferase 1 0.1843 0.0230
Rcl1 RNA 3'-terminal phosphate cyclase-like protein 0.1840 0.0372
Adra2b alpha-2B adrenergic receptor 0.1832 0.0060
Septin8 septin-8 0.1828 0.0177
Ptbp1 polypyrimidine tract-binding protein 1 0.1827 0.0278
Idh3g isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 0.1826 0.0341
Wdr12 ribosome biogenesis protein WDR12 0.1817 0.0204
Calcoco1 calcium-binding and coiled-coil domain-containing protein 1 0.1800 0.0062
Fubp1 far upstream element-binding protein 1 0.1792 0.0110
Tax1bp1 tax1-binding protein 1 0.1791 0.0350
Crym ketimine reductase mu-crystallin 0.1783 0.0190
Spout1 putative methyltransferase C9orf114 0.1771 0.0422
Ahnak2 protein AHNAK2 0.1767 0.0437
Mtmr3 myotubularin-related protein 3 0.1756 0.0010
Snw1 SNW domain-containing protein 1 0.1752 0.0358
Safb2 scaffold attachment factor B2 0.1749 0.0075
Bbs2 Bardet-Biedl syndrome 2 protein 0.1746 0.0198
Tpd52l1 tumor protein D53 0.1734 0.0288
Kifc3 kinesin-like protein KIFC3 0.1732 0.0213
Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 0.1730 0.0219
Hdhd5 haloacid dehalogenase-like hydrolase domain-containing 5 0.1726 0.0335
Pofut1 GDP-fucose protein O-fucosyltransferase 1 0.1720 0.0446
Plekha6 pleckstrin homology domain-containing family A member 6 0.1716 0.0204
Snrnp40 U5 small nuclear ribonucleoprotein 40 kDa protein 0.1714 0.0253
Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like 0.1707 0.0212
Pqbp1 polyglutamine-binding protein 1 0.1697 0.0346
Thap4 peroxynitrite isomerase THAP4 0.1696 0.0002
Upp2 uridine phosphorylase 2 0.1691 0.0346
Jmjd6 bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 0.1679 0.0194
Nedd1 protein NEDD1 0.1675 0.0019
Mustn1 musculoskeletal embryonic nuclear protein 1 0.1627 0.0220
Get3 ATPase GET3 0.1619 0.0137
Safb scaffold attachment factor B1 0.1603 0.0274
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.1584 0.0029
Bloc1s5 biogenesis of lysosome-related organelles complex 1 subunit 5 0.1578 0.0154
Spns1 protein spinster homolog 1 0.1565 0.0214
Dhrs13 dehydrogenase/reductase SDR family member 13 0.1562 0.0187
Pck1 phosphoenolpyruvate carboxykinase, cytosolic [GTP] 0.1558 0.0007
Arvcf splicing regulator ARVCF 0.1551 0.0092
Rab4b ras-related protein Rab-4B 0.1551 0.0135
Tsr3 18S rRNA aminocarboxypropyltransferase 0.1540 0.0122
Dhx9 ATP-dependent RNA helicase A 0.1539 0.0185
Kng2 kininogen 2 0.1534 0.0166
Fubp3 far upstream element-binding protein 3 0.1504 0.0023
Ptcd3 pentatricopeptide repeat domain-containing protein 3, mitochondrial 0.1491 0.0148
Rpl8 60S ribosomal protein L8 0.1479 0.0119
C1galt1c1 C1GALT1-specific chaperone 1 0.1474 0.0168
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.1451 0.0138
Zc3h11a zinc finger CCCH domain-containing protein 11A 0.1449 0.0054
Commd2 COMM domain-containing protein 2 0.1435 0.0076
Sdsl serine dehydratase-like 0.1420 0.0060
Kcnj16 inward rectifier potassium channel 16 0.1411 0.0007
Glul glutamine synthetase 0.1403 0.0065
Tsc22d3 TSC22 domain family protein 3 0.1402 0.0072
Sod3 extracellular superoxide dismutase [Cu-Zn] preproprotein 0.1358 0.0095
Kti12 protein KTI12 homolog 0.1330 0.0039
Rpl27 60S ribosomal protein L27 0.1330 0.0013
Dcaf8 DDB1- and CUL4-associated factor 8 0.1289 0.0030
Gpx1 glutathione peroxidase 1 -0.1370 0.0102
D17h6s53e uncharacterized protein C6orf47 homolog -0.1372 0.0003
Cdc16 cell division cycle protein 16 homolog -0.1374 0.0115
Gmppa mannose-1-phosphate guanyltransferase alpha -0.1411 0.0093
Rpl11 60S ribosomal protein L11 -0.1448 0.0111
Evpl envoplakin -0.1458 0.0073
Cyb5r3 NADH-cytochrome b5 reductase 3 -0.1465 0.0162
Tnfaip1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 -0.1483 0.0148
Phykpl 5-phosphohydroxy-L-lysine phospho-lyase -0.1525 0.0130
Srbd1 S1 RNA-binding domain-containing protein 1 -0.1540 0.0031
Naalad2 N-acetylated-alpha-linked acidic dipeptidase 2 -0.1544 0.0044
Txlng gamma-taxilin -0.1561 0.0203
Tnfaip2 tumor necrosis factor alpha-induced protein 2 -0.1577 0.0230
Nacc1 nucleus accumbens-associated protein 1 -0.1581 0.0169
Fuca2 plasma alpha-L-fucosidase -0.1600 0.0052
Abhd3 phospholipase ABHD3 -0.1619 0.0178
Kpna3 importin subunit alpha-4 -0.1632 0.0047
Otub2 ubiquitin thioesterase OTUB2 -0.1632 0.0119
Spata5 ribosome biogenesis protein SPATA5 -0.1659 0.0292
Aplf aprataxin and PNK-like factor -0.1727 0.0311
Mcrip1 mapk-regulated corepressor-interacting protein 1 -0.1739 0.0368
Dnmbp dynamin-binding protein -0.1759 0.0169
Nek6 serine/threonine-protein kinase Nek6 -0.1777 0.0234
Pipox peroxisomal sarcosine oxidase -0.1805 0.0500
Hltf helicase-like transcription factor -0.1839 0.0066
Rpp38 ribonuclease P protein subunit p38 -0.1857 0.0169
Cyp2c29 cytochrome P450 2C29 -0.1877 0.0429
Spcs3 signal peptidase complex subunit 3 -0.1908 0.0008
Prpf38a pre-mRNA-splicing factor 38A -0.1914 0.0014
Phactr1 phosphatase and actin regulator 1 -0.1917 0.0482
Atp6v1f V-type proton ATPase subunit F -0.2007 0.0309
Apof apolipoprotein F preproprotein -0.2023 0.0444
Rnf31 E3 ubiquitin-protein ligase RNF31 -0.2024 0.0143
Tfrc transferrin receptor protein 1 -0.2055 0.0137
Acaa1a 3-ketoacyl-CoA thiolase A, peroxisomal -0.2075 0.0417
Slc30a7 zinc transporter 7 -0.2092 0.0374
Nceh1 neutral cholesterol ester hydrolase 1 -0.2096 0.0287
Atg4c cysteine protease ATG4C -0.2131 0.0157
Ints11 integrator complex subunit 11 -0.2152 0.0275
Cry2 cryptochrome-2 -0.2171 0.0255
Rpl35 60S ribosomal protein L35 -0.2172 0.0241
Kif11 kinesin-like protein KIF11 -0.2186 0.0140
Rpl27a 60S ribosomal protein L27a -0.2195 0.0129
Itfg1 T-cell immunomodulatory protein -0.2198 0.0145
Mup3 major urinary protein 3 -0.2201 0.0073
Klk1 kallikrein-1 preproprotein -0.2221 0.0458
Sesn2 sestrin-2 -0.2231 0.0238
Prdx2 peroxiredoxin-2 -0.2259 0.0258
Ca15 carbonic anhydrase 15 -0.2287 0.0437
Mageh1 melanoma-associated antigen H1 -0.2309 0.0484
Atp6ap2 renin receptor -0.2329 0.0021
Tubb3 tubulin beta-3 chain -0.2354 0.0466
Rpl39 60S ribosomal protein L39 -0.2369 0.0123
Ago1 protein argonaute-1 -0.2380 0.0055
Hsd17b11 estradiol 17-beta-dehydrogenase 11 -0.2386 0.0019
Ftsj1 putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase -0.2400 0.0172
Adh4 all-trans-retinol dehydrogenase [NAD(+)] ADH4 -0.2415 0.0075
Bcorl1 BCL-6 corepressor-like protein 1a -0.2435 0.0047
Pyroxd1 pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 -0.2471 0.0136
Yes1 tyrosine-protein kinase Yes -0.2478 0.0042
Sec22a vesicle-trafficking protein SEC22a -0.2490 0.0307
Snrpd3 small nuclear ribonucleoprotein Sm D3 -0.2513 0.0081
Atp6v1d V-type proton ATPase subunit D -0.2521 0.0030
Eva1b protein eva-1 homolog B -0.2616 0.0113
Slc12a4 solute carrier family 12 member 4 -0.2626 0.0174
Timm8b mitochondrial import inner membrane translocase subunit Tim8 B -0.2705 0.0021
Slc12a1 solute carrier family 12 member 1 -0.2715 0.0090
Kcnmb3 calcium-activated potassium channel subunit beta-3 -0.2760 0.0225
Apaf1 apoptotic protease-activating factor 1 -0.2844 0.0374
Med25 mediator of RNA polymerase II transcription subunit 25 -0.2860 0.0008
Plau urokinase-type plasminogen activator -0.2917 0.0282
Atp6v1b1 V-type proton ATPase subunit B, kidney isoform -0.2939 0.0130
Xrcc1 DNA repair protein XRCC1 -0.2940 0.0156
Tstd2 thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 -0.2995 0.0048
Trim68 E3 ubiquitin-protein ligase TRIM68 -0.3078 0.0072
Slc25a15 mitochondrial ornithine transporter 1 -0.3142 0.0283
Pgk2 phosphoglycerate kinase 2 -0.3155 0.0021
Hsd3b2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 -0.3209 0.0140
Atp6v1g3 V-type proton ATPase subunit G 3 -0.3411 0.0035
Ak6 adenylate kinase isoenzyme 6 -0.3656 0.0316
Ncapg condensin complex subunit 3 -0.3794 0.0006
Apom apolipoprotein M -0.3920 0.0500
Vasn vasorin -0.4099 0.0320
Atp6v0d2 V-type proton ATPase subunit d 2 -0.4128 0.0009
Apoa4 apolipoprotein A-IV -0.4222 0.0441
Ces1b carboxylesterase 1B -0.4382 0.0466
Slc35f1 solute carrier family 35 member F1 -0.4478 0.0147
Apoa2 apolipoprotein A-II preproprotein -0.4494 0.0363
Lig3 DNA ligase 3lpha -0.4579 0.0057
Lss lanosterol synthase -0.4893 0.0194
Nom1 nucleolar MIF4G domain-containing protein 1 -0.5663 0.0093
Syngr3 synaptogyrin-3 -0.6852 0.0044
B4galnt1 beta-1,4 N-acetylgalactosaminyltransferase 1 -0.7703 0.0370
Angel2 protein angel homolog 2 -0.7979 0.0004
Plp1 myelin proteolipid protein -1.2714 0.0188
Mbp Golli-MBP -1.6364 0.0386
Gene Symbol Annotation Log2 (ZT12/ZT0) P (t-test)

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