Below are the lysine acetyltransferases found in mammals. The information was culled and curated from several existing resources (click to open): Histome: The Histone Infobase, UniProtKB, NCBI, Rat Genome Database, Cell Signaling Technology, Drazic et al.2016. Lysine acetyltransferases must bind acetyl-Coenzyme A and have a catalytic domain. BLAST searches with conserved catalytic domains were completed to identify putative novel lysine acetyltransferases. Proteins that may have acetyltransferase activity, but lack experimental evidence for intrinsic activity are listed as putative lysine acetyltransferases. 9 putative proteins are listed below. Taf1L is only expressed by primates, and Fcor is only found in mice.
To see where these acetyltransferases are expressed along the nephron click here.
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Reference: Hyndman KA, Knepper MA. Dynamic regulation of lysine acetylation; the balance between acetyltransferase and deacetylase activities. Am J Physiol Renal Physiol. 2017 Jul 12:ajprenal.00313.2017. PMID: 28701313
| Uniprot | Protein Name | Gene Symbol | Aliases | Amino Acid Number | Predominant localization | Substrates |
| P16951 | cyclic AMP-dependent transcription factor ATF-2 | Atf2 | CREB-2, HB15, CREBP1 | 487 | nucleus, cytoplasm, mitochonrdion outer membrane | H2BK5, H2BK12, H2BK15, H4K5, H4K8, H4K16 |
| Q9WTK2 | chromodomain Y-like protein | Cdyl | CDYL1 | 593 | nucleus | H4 |
| O08785 | circadian locomoter output cycles protein kaput | Clock | BHLHE8, KIAA0334, KAT13D | 855 | nucleus, cytoplasm | H3K14, ARNTL/BMAL1, NR3C1/GR |
| P45481 | CREB-binding protein | Crebbp | CBP | 2441 | nucleus, cytoplasm | H2BK12, H2BK15, H3K18, H3K23, H3K27, H3K56, H4K5, H4K8, H4K12, H4K16 NCOA,FOXO1, KLF1 |
| Q9CZX0 | elongator complex protein 3 | Elp3 | KAT9 | 566 | nucleus, cytoplasm | H3K9, H3K14,H3K18, H4K8, a -tubulin |
| B2RWS6 | histone acetyltransferase p300 | Ep300 | P300 | 2412 | nucleus, cytoplasm | H2AK5, H2B, H3K14, H3K18, H3K23, H3K27, H3K56, H4K5, H4K8, H4K12, H4K16, , FOXO1, HD1, SIRT2, ALX1, KLF1 |
| Q8BMQ2 | general transcription factor 3C polypeptide 4 | Gtf3c4 | TF3C-delta, TFIIIC90, KAT12 | 817 | nucleus | H3K14 |
| Q8BY71 | histone acetyltransferase type B catalytic subunit | Hat1 | KAT1 | 416 | nucleus>cytoplasm | H2A,H4K5, H4K12, |
| Q9JHD2 | histone acetyltransferase KAT2A | Kat2a | GCN5, GCN5L2, HGCN5 | 830 | nucleus | H3K9, H3K14, H3K18, H3K23, H3K27, H3K36, H4K5, H4K8, H4K12, H4K16, H4K91, CEBPB |
| Q9JHD1 | histone acetyltransferase KAT2B | Kat2b | PCAF | 813 | nucleus | H3K14, H4K8, ACLY, E2F1 |
| Q8CHK4 | histone acetyltransferase KAT5 | Kat5 | HTATIP, TIP60 | 513 | nucleus, perinuclear region in cytoplasm | H3K14, H4K5, H4K8, H4K12, H2AK5,FOXP3 |
| Q8BZ21 | histone acetyltransferase KAT6A | Kat6a | MOZ, MYST3, RUNXBP2, ZNF220 | 2003 | nucleus | H3K14, H4, P53,RUNX2 |
| Q8BRB7 | histone acetyltransferase KAT6B | Kat6b | MORF, MYST4, MOZ2, KIAA0383 | 1763 | nucleus | H3, RUNX2 |
| Q5SVQ0 | histone acetyltransferase KAT7 | Kat7 | HBO1, HBOa, MYST2 | 611 | nucleus | H4K5, H4K8, H4K12 |
| Q9D1P2 | histone acetyltransferase KAT8 | Kat8 | Mof, Myst1 | 458 | nucleus | H4K16, P53 |
| P70365 | nuclear receptor coactivator 1 | Ncoa1 | Src1, KAT13A | 1405 | nucleus | H3K9, H3K14, H4 |
| O09000 | nuclear receptor coactivator 3 | Ncoa3 | SRC-3, Aib1, Pcip, Rac3, Tram1, ACTR, KAT13B | 1403 | nucelus, cytoplasm | H3, H4 |
| Q80UV9 | transcription initiation factor TFIID subunit 1 | Taf1 | Ccg1, KAT4 | 1893 | nucleus | H3K14, H4 |
| Q8QZT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acat1 | 424 | mitochondrion | 6PDG, PDP | |
| Q8K341 | alpha-tubulin N-acetyltransferase 1 | Atat1 | Mec17 | 421 | cytoplasm | a -tubulin |
| Q8K224 | RNA cytidine acetyltransferase | Nat10 | Kiaa1709 | 1024 | nucleus | histones,a -tubulin |
| Putative lysine acetylatransferases | ||||||
| Q8IZX4 | Transcription initiation factor TFIID subunit 1-like | Taf1L | TAF(II)210 | 1826 | nucleus | ? |
| P0DJI6 | Foxo1-corepressor | Fcor | none | 106 | nucleus, cytoplasm | FOXO1 |
| Q9ER73 | elongator complex protein 4 | Elp4 | C11orf19, PAXNEB | 422 | nucleus, cytoplasm | H3, H4 |
| Q8CID0 | Cysteine-rich protein 2-binding protein | Kat14 | CSRP2BP, ATAC2 | 779 | nucleus>cytoplasm | H4 |
| A2AUU0 | methyltransferase-like protein 8 | Mettl8 | Tip | 312 | nucleus, cytoplasm | H3, H4 |
| Q9DBU2 | N-alpha-acetyltransferase 60 isoform 1 | Naa60 | HAT4,NatF, Nat15 | 242 | Golgi aparatus membrane, cyoplasmic side | H4K79, H4K91 |
| Q9EQQ9 | Protein O-GlcNAcase | Mgea5 | NCOAT, OGA | 916 | nucleus, cytoplasm | H4K8, H3K14 |
| E9QA25* | cat eye syndrome critical region protein 2 | Cecr2 | none | 1425 | nucleus | ? |
| O55102 | Biogenesis of lysosome-related organelles complex 1 subunit 1 | Bloc1s1 | Gcn5l1 | 125 | mitochondrion, cytoplasm | ATP5A1, NDUFA9 |
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