Below are the lysine deacetylases found in mammals. The information was culled and curated from several existing resources (click to open): Histome: The Histone Infobase, UniProtKB, NCBI, Rat Genome Database,Drazic et al.2016. By BLAST searches with conserved catalytic domains, we found 3 putative novel lysine deacetylase enzymes (Fam118A, Famm118B, HDA1L). HDAC1L is exclusively expressed by rats.
To see expression of the deacetylases along the rat nephron click here.
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Reference: Hyndman KA, Knepper MA. Dynamic regulation of lysine acetylation; the balance between acetyltransferase and deacetylase activities. Am J Physiol Renal Physiol. 2017 Jul 12:ajprenal.00313.2017. PMID: 28701313
| UniProt | Protein Name | Gene Symbol | Amino Acid Number | Cofactor | Pfam Conserved Domain | Predominant Localization | Known Substrates |
| O09106 | Histone deacetylase 1 | Hdac1 | 482 | Zn2+ | Hist_deacetyl | nucleus | H3K56, H2A, H2B, H4, RELA,AR,NR1D2, TSHZ3 |
| P70288 | Histone deacetylase 2 | Hdac2 | 488 | Zn2+ | Hist_deacetyl | nucleus | H2A, H2B, H3, H4, TSHZ3 |
| O88895 | Histone deacetylase 3 | Hdac3 | 428 | Zn2+ | Hist_deacetyl | nucleus | H2A, H2B, H3K4, H3K27, H4, NF-KB, KAT2B, STAT1, RELA |
| Q6NZM9 | Histone deacetylase 4 | Hdac4 | 1076 | Zn2+ | Hist_deacetyl | nulceus,cytosol | H2A, H2B, H3, H4, HIF1α, p53, HSPA1A, HSPA1B |
| Q9Z2V6 | Histone deacetylase 5 | Hdac5 | 1115 | Zn2+ | Hist_deacetyl | nulceus,cytosol | GATA-2, GCM1,α-tubulin |
| Q9Z2V5 | Histone deacetylase 6 | Hdac6 | 1149 | Zn2+ | Hist_deacetyl | cytosol | CTTN, α-tubulin, HSP90 |
| Q8C2B3 | Histone deacetylase 7 | Hdac7 | 953 | Zn2+ | Hist_deacetyl | nulceus/cytosol/mitochondrion inner membrane space | PLAG1 |
| Q8VH37 | Histone deacetylase 8 | Hdac8 | 377 | Zn2+ | Hist_deacetyl | nulceus,cytosol | H2A, H2B, H3, H4, p53, ERRα |
| Q99N13 | Histone deacetylase 9 | Hdac9 | 1088 | Zn2+ | Hist_deacetyl | nulceus,cytosol | ATDC |
| Q6P3E7 | Histone deacetylase 10 | Hdac10 | 666 | Zn2+ | Hist_deacetyl | cytosol | HSP70, PP1 |
| Q91WA3 | Histone deacetylase 11 | Hdac11 | 347 | Zn2+ | Hist_deacetyl | nulceus,cytosol | H2A, H2B, H3, H4 |
| Q923E4 | Sirtuin-1 | Sirt1 | 737 | NAD+, Zn2+ | Sir2 | nucleus | H4K16, H3K9, H1K25, P53, FOXO1, HSF1, KAT7, CBP |
| Q8VDQ8 | Sirtuin-2 | Sirt2 | 389 | NAD+, Zn2+ | Sir2 | nucleus, cytosol | H4K16, H3K56, α-tubulin |
| Q8R104 | Sirtuin-3 | Sirt3 | 334 | NAD+, Zn2+ | Sir2 | mitochondrion matrix, nucleus | H3K56, GLUD1, Ku70, ACSS1 |
| Q8R216 | Sirtuin-4 | Sirt4 | 333 | NAD+, Zn2+ | Sir2 | mitochondrion matrix | GLUD1 |
| Q8K2C6 | Sirtuin-5 | Sirt5 | 310 | NAD+, Zn2+ | Sir2 | mitochondrion matrix and inter-membrane space, cytoplasm, nucleus | CPS1, CYCS |
| P59941 | Sirtuin-6 | Sirt6 | 334 | NAD+, Zn2+ | Sir2 | nucleus | H3K9, H3K5, RBBP8 |
| Q8BKJ9 | Sirtuin-7 | Sirt7 | 402 | NAD+, Zn2+ | Sir2 | nucleus | H3K18, POLR1E |
| Q91YN1 | Family with sequence similarity 118, member A | Fam118a | 357 | ? | Sir2-like | membrane | ? |
| Q8C569 | Family with sequence similarity 118, member B | Fam118b | 351 | ? | Sir2-like | cajal bodies in nucleus | ? |
| D3ZVU7 | histone deacetylase 1-like | Hdac1l | 484 | ? | Hist_deacetyl | cytosol (predicted) | ? |
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