Below are the lysine deacetylases found in mammals and their expression along the rat nephron. This database provides median RPKM values for the transcriptome of 14 separate renal tubule segments in untreated male Sprague-Dawley rats (200-250 g BW). The number of replicates is shown in parentheses. The rat RNA-Seq analysis of microdissected rat kidney tubule segments was published by: Lee JW, Chou CL, and Knepper MA. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol 2015 Mar 27. pii: ASN.2014111067 PMID: 25817355
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Reference: paper under review
This website was created by Kelly Hyndman and Mark Knepper. Contact us with questions or comments: knep@helix.nih.gov or hyndmank@uab.edu.
| UniProt | Protein Name | Gene | S1 | S2 | S3 | SDL | LDLOM | LDLIM | tAL | mTAL | cTAL | DCT | CNT | CCD | OMCD | IMCD |
| Symbol | (7) | (7) | (7) | (10) | (9) | (4) | (7) | (7) | (7) | (9) | (6) | (11) | (7) | (8) | ||
| O09106 | Histone deacetylase 1 | Hdac1 | 0.1 | 0.7 | 3.8 | 10.6 | 0.1 | 20.8 | 25.9 | 3.9 | 2.9 | 4.7 | 3.1 | 9.5 | 7.6 | 9.7 |
| P70288 | Histone deacetylase 2 | Hdac2 | 0.1 | 1.4 | 0.4 | 0.7 | 0.2 | 14.9 | 16.9 | 6.4 | 8.2 | 2.6 | 21.2 | 12.8 | 4.9 | 14.7 |
| O88895 | Histone deacetylase 3 | Hdac3 | 3.3 | 3.1 | 3.0 | 12.9 | 0.0 | 7.0 | 12.4 | 0.1 | 6.3 | 7.2 | 5.8 | 5.1 | 34.2 | 11.8 |
| Q6NZM9 | Histone deacetylase 4 | Hdac4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 1.0 | 0.3 | 1.2 | 1.5 | 0.2 | 0.1 |
| Q9Z2V6 | Histone deacetylase 5 | Hdac5 | 0.3 | 0.1 | 0.1 | 2.8 | 0.0 | 4.9 | 28.9 | 2.5 | 11.8 | 12.1 | 14.3 | 37.5 | 3.1 | 20.3 |
| Q8VH37 | Histone deacetylase 8 | Hdac8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.0 | 0.0 | 0.3 | 0.0 | 0.0 |
| Q99N13 | Histone deacetylase 9 | Hdac9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Q6P3E7 | Histone deacetylase 10 | Hdac10 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.2 | 0.3 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 3.2 |
| Q91WA3 | Histone deacetylase 11 | Hdac11 | 0.2 | 5.3 | 0.7 | 0.2 | 0.1 | 2.0 | 5.7 | 5.0 | 13.4 | 4.4 | 0.3 | 2.4 | 0.8 | 0.0 |
| Q8VDQ8 | Sirtuin-2 | Sirt2 | 11.4 | 14.7 | 33.1 | 67.4 | 47.2 | 31.6 | 19.2 | 0.7 | 33.6 | 24.0 | 25.1 | 30.2 | 54.7 | 32.9 |
| Q8R104 | Sirtuin-3 | Sirt3 | 1.5 | 14.6 | 0.0 | 0.2 | 0.0 | 0.4 | 0.5 | 0.8 | 20.9 | 11.0 | 14.2 | 12.9 | 0.3 | 3.2 |
| Q8R216 | Sirtuin-4 | Sirt4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.5 | 0.1 | 0.0 | 0.7 | 0.1 | 0.4 | 0.0 | 0.0 | 2.0 |
| Q8K2C6 | Sirtuin-5 | Sirt5 | 1.5 | 2.3 | 0.0 | 7.1 | 16.9 | 5.2 | 2.4 | 1.7 | 11.5 | 17.9 | 6.5 | 13.4 | 0.1 | 6.7 |
| P59941 | Sirtuin-6 | Sirt6 | 0.3 | 0.2 | 0.6 | 2.8 | 0.2 | 8.7 | 0.7 | 2.5 | 4.7 | 7.3 | 17.1 | 27.0 | 0.0 | 16.3 |
| Q8BKJ9 | Sirtuin-7 | Sirt7 | 0.4 | 1.8 | 3.3 | 0.2 | 0.0 | 4.9 | 2.8 | 2.1 | 22.4 | 5.7 | 5.2 | 22.4 | 0.0 | 10.1 |
| Q91YN1 | Family with sequence similarity 118, member A | Fam118a | 0.4 | 2.4 | 0.9 | 6.2 | 1.9 | 33.6 | 5.8 | 11.6 | 9.9 | 5.2 | 11.5 | 14.9 | 36.5 | 16.3 |
| Q8C569 | Family with sequence similarity 118, member B | Fam118b | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.3 |
| D3ZVU7 | Histone deacetylase 1-like | Hdac1l | 0.0 | 0.1 | 0.0 | 1.4 | 0.1 | 2.9 | 1.9 | 0.0 | 0.1 | 0.5 | 0.1 | 0.7 | 0.2 | 1.4 |
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