National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)

Human E3 Ubiquitin Ligase Accessory Proteins

These proteins are related to the active E3 Ubiquitin Ligases and can be sorted alphabetically by Gene Symbol or Class by clicking on the respective header.

This list was created primarily from Supplemental Table 1 of Li et al , with the addition of the Cullin proteins.

 

This database was created by Barbara Medvar, Abhijit Sarkar, and Mark A. Knepper. Please contact Mark Knepper with any comments or questions.

 

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  Gene Symbol

  Protein Name

  Accession No.

  Class

ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 NP_115937 BTB
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 NP_665803 BTB
ANKFY1 ankyrin repeat and FYVE domain containing 1 NP_057460 BTB
ARMC5 armadillo repeat containing 5 NP_079018 BTB
ASB10 ankyrin repeat and SOCS box-containing 10 NP_543147 SOCS box
ASB11 ankyrin repeat and SOCS box-containing 11 NP_001012428 SOCS box
ASB13 ankyrin repeat and SOCS box-containing 13 NP_078977 SOCS box
ASB14 ankyrin repeat and SOCS box-containing 14 NP_569058 SOCS box
ASB15 ankyrin repeat and SOCS box-containing 15 NP_563616 SOCS box
ASB16 ankyrin repeat and SOCS box-containing 16 NP_543139 SOCS box
ASB17 ankyrin repeat and SOCS box-containing 17 NP_543144 SOCS box
ASB18 ankyrin repeat and SOCS box-containing 18 NP_997721 SOCS box
ASB2 ankyrin repeat and SOCS box-containing 2 NP_057234 SOCS box
ASB3 ankyrin repeat and SOCS box-containing 3 NP_057199 SOCS box
ASB4 ankyrin repeat and SOCS box-containing 4 NP_057200 SOCS box
ASB5 ankyrin repeat and SOCS box-containing 5 NP_543150 SOCS box
ASB6 ankyrin repeat and SOCS box-containing 6 NP_060343 SOCS box
ASB7 ankyrin repeat and SOCS box-containing 7 NP_078984 SOCS box
ASB8 ankyrin repeat and SOCS box-containing 8 NP_077000 SOCS box
ASB9 ankyrin repeat and SOCS box-containing 9 NP_001026909 SOCS box
ATRX RAD54 homolog NP_612115 PHD
BACH1 BTB and CNC homology 1, bLZ transcription factor 1 NP_001011545 BTB
BACH2 BTB and CNC homology 1, bLZ transcription factor 2 NP_068585 BTB
BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) NP_001697 BTB
BCL6B B-cell CLL/lymphoma 6, member B (zinc finger protein) NP_862827 BTB
BTBD1 BTB (POZ) domain containing 1 NP_001011885 BTB
BTBD10 BTB (POZ) domain containing 10 NP_115696 BTB
BTBD11 BTB (POZ) domain containing 11 NP_001017523 BTB
BTBD17 galectin-3-binding protein-like NP_001073935 BTB
BTBD2 BTB (POZ) domain containing 2 NP_060267 BTB
BTBD3 BTB (POZ) domain containing 3 NP_055777 BTB
BTBD6 BTB (POZ) domain containing 6 NP_150374 BTB
BTBD7 BTB (POZ) domain containing 7 NP_001002860 BTB
BTBD8 BTB (POZ) domain containing 8 NP_899065 BTB
BTBD9 BTB (POZ) domain containing 9 NP_689946 BTB
BTRC beta-transducin repeat containing NP_003930 F-box
CCIN calicin NP_005884 BTB
CCNF cyclin F NP_001752 F-box
CISH cytokine inducible SH2-containing protein NP_659508 SOCS box
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa NP_037423 CPSF_A
CUL1 cullin-1 NP_003583 Cullin
CUL2 cullin-2 isoform b NP_001185708 Cullin
CUL3 cullin-3 isoform 3 NP_001244127 Cullin
CUL4A cullin-4A isoform 3 NP_001265443 Cullin
CUL4B cullin-4B isoform 2 NP_001073341 Cullin
CUL5 cullin-5 NP_003469 Cullin
CUL7 cullin-7 isoform 1 NP_001161842 Cullin
DDB1 damage-specific DNA binding protein 1, 127kDa NP_001914 CPSF_A
DPF1 D4, zinc and double PHD fingers family 1 NP_004638 PHD
ECT2L lung specific F-box and DH domain containing protein NP_001071174 F-box
ENC1 ectodermal-neural cortex (with BTB-like domain) NP_003624 BTB
FBXL12 F-box and leucine-rich repeat protein 12 NP_060173 F-box
FBXL13 F-box and leucine-rich repeat protein 13 NP_659469 F-box
FBXL14 F-box and leucine-rich repeat protein 14 NP_689654 F-box
FBXL15 F-box and leucine-rich repeat protein 15 NP_077302 F-box
FBXL16 F-box and leucine-rich repeat protein 16 NP_699181 F-box
FBXL18 F-box and leucine-rich repeat protein 18 NP_079239 F-box
FBXL2 F-box and leucine-rich repeat protein 2 NP_036289 F-box
FBXL20 F-box and leucine-rich repeat protein 20 NP_116264 F-box
FBXL3 F-box and leucine-rich repeat protein 3 NP_036290 F-box
FBXL4 F-box and leucine-rich repeat protein 4 NP_036292 F-box
FBXL5 F-box and leucine-rich repeat protein 5 NP_036293 F-box
FBXL6 F-box and leucine-rich repeat protein 6 NP_036294 F-box
FBXL7 F-box and leucine-rich repeat protein 7 NP_036436 F-box
FBXL8 F-box and leucine-rich repeat protein 8 NP_060848 F-box
FBXO10 F-box protein 10 NP_036298 F-box
FBXO11 F-box protein 11 NP_036299 F-box
FBXO15 F-box protein 15 NP_689889 F-box
FBXO16 F-box protein 16 NP_758954 F-box
FBXO17 F-box protein 17 NP_079183 F-box
FBXO18 F-box protein, helicase, 18 NP_116196 F-box
FBXO2 F-box protein 2 NP_036300 F-box
FBXO21 F-box protein 21 NP_055817 F-box
FBXO22 F-box protein 22 NP_036302 F-box
FBXO24 F-box protein 24 NP_036304 F-box
FBXO25 F-box protein 25 NP_036305 F-box
FBXO27 F-box protein 27 NP_849142 F-box
FBXO28 F-box protein 28 NP_055991 F-box
FBXO3 F-box protein 3 NP_036307 F-box
FBXO30 F-box protein 30 NP_115521 F-box
FBXO31 F-box protein 31 NP_079011 F-box
FBXO32 F-box protein 32 NP_478136 F-box
FBXO33 F-box protein 33 NP_976046 F-box
FBXO34 F-box protein 34 NP_060413 F-box
FBXO36 F-box protein 36 NP_777559 F-box
FBXO38 F-box protein 38 NP_110420 F-box
FBXO4 F-box protein 4 NP_036308 F-box
FBXO40 F-box protein 40 NP_057382 F-box
FBXO41 F-box protein 41 NP_001073879 F-box
FBXO42 F-box protein 42 NP_061867 F-box
FBXO44 F-box protein 44 NP_001014765 F-box
FBXO45 F-box protein 45 XP_936650 F-box
FBXO46 F-box protein 46 NP_001073938 F-box
FBXO5 F-box protein 5 NP_036309 F-box
FBXO6 F-box protein 6 NP_060908 F-box
FBXO7 F-box protein 7 NP_001028196 F-box
FBXO8 F-box protein 8 NP_036312 F-box
FBXO9 F-box protein 9 NP_036479 F-box
FBXW11 F-box and WD repeat domain containing 11 NP_036432 F-box
FBXW2 F-box and WD repeat domain containing 2 NP_036296 F-box
FBXW4 F-box and WD repeat domain containing 4 NP_071322 F-box
FBXW5 F-box and WD repeat domain containing 5 NP_061871 F-box
FBXW7 F-box and WD repeat domain containing 7 NP_001013433 F-box
FBXW8 F-box and WD repeat domain containing 8 NP_036306 F-box
GAN giant axonal neuropathy (gigaxonin) NP_071324 BTB
GMCL1 germ cell-less homolog 1 (Drosophila) NP_848526 BTB
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa NP_001506 vWA_transcription_factor_IIH_type
GZF1 GDNF-inducible zinc finger protein 1 NP_071927 BTB
HIC1 hypermethylated in cancer 1 NP_001091672 BTB
HIC2 hypermethylated in cancer 2 NP_055909 BTB
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase NP_056340 BTB
IPP intracisternal A particle-promoted polypeptide NP_005888 BTB
IVNS1ABP influenza virus NS1A binding protein NP_057473 BTB
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 NP_055682 BTB
KBTBD12 kelch domain containing 6 NP_997218 BTB
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 NP_056298 BTB
KBTBD3 kelch repeat and BTB (POZ) domain containing 3 NP_689646 BTB
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 NP_057590 BTB
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 NP_690867 BTB
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 NP_115514 BTB
KBTBD8 kelch repeat and BTB (POZ) domain containing 8 NP_115894 BTB
KBTBD9 kelch-like 29 (Drosophila) XP_001134449 BTB
KCNA1 K voltage-gated channel, shaker-related subfamily, member 1 NP_000208 BTB
KCNA10 K voltage-gated channel, shaker-related subfamily, member 10 NP_005540 BTB
KCNA2 K voltage-gated channel, shaker-related subfamily, member 2 NP_004965 BTB
KCNA3 K voltage-gated channel, shaker-related subfamily, member 3 NP_002223 BTB
KCNA4 K voltage-gated channel, shaker-related subfamily, member 4 NP_002224 BTB
KCNA5 K voltage-gated channel, shaker-related subfamily, member 5 NP_002225 BTB
KCNA6 K voltage-gated channel, shaker-related subfamily, member 6 NP_002226 BTB
KCNA7 K voltage-gated channel, shaker-related subfamily, member 7 NP_114092 BTB
KCNB1 K voltage-gated channel, Shab-related subfamily, member 1 NP_004966 BTB
KCNB2 K voltage-gated channel, Shab-related subfamily, member 2 NP_004761 BTB
KCNC1 K voltage-gated channel, Shaw-related subfamily, member 1 NP_004967 BTB
KCNC2 K voltage-gated channel, Shaw-related subfamily, member 2 NP_631874 BTB
KCNC3 K voltage-gated channel, Shaw-related subfamily, member 3 NP_004968 BTB
KCNC4 K voltage-gated channel, Shaw-related subfamily, member 4 NP_001034663 BTB
KCND1 K voltage-gated channel, Shal-related subfamily, member 1 NP_004970 BTB
KCND2 K voltage-gated channel, Shal-related subfamily, member 2 NP_036413 BTB
KCND3 K voltage-gated channel, Shal-related subfamily, member 3 NP_004971 BTB
KCNG1 K voltage-gated channel, subfamily G, member 1 NP_002228 BTB
KCNG3 K voltage-gated channel, subfamily G, member 3 NP_579875 BTB
KCNRG K channel regulator NP_775876 BTB
KCNS1 K voltage-gated channel, delayed-rectifier, member 1 NP_002242 BTB
KCNS2 K voltage-gated channel, delayed-rectifier, member 2 NP_065748 BTB
KCNS3 K voltage-gated channel, delayed-rectifier, member 3 NP_002243 BTB
KCNV1 K channel, subfamily V, member 1 NP_055194 BTB
KCTD1 K channel tetramerisation domain containing 1 NP_945342 BTB
KCTD10 K channel tetramerisation domain containing 10 NP_114160 BTB
KCTD12 K channel tetramerisation domain containing 12 NP_612453 BTB
KCTD13 K channel tetramerisation domain containing 13 NP_849194 BTB
KCTD14 K channel tetramerisation domain containing 14 NP_076419 BTB
KCTD15 K channel tetramerisation domain containing 15 NP_076981 BTB
KCTD16 K channel tetramerisation domain containing 16 NP_065819 BTB
KCTD17 K channel tetramerisation domain containing 17 NP_078957 BTB
KCTD2 K channel tetramerisation domain containing 2 NP_056168 BTB
KCTD20 K channel tetramerisation domain containing 20 NP_775833 BTB
KCTD21 K channel tetramerisation domain containing 21 NP_001025030 BTB
KCTD3 K channel tetramerisation domain containing 3 NP_057205 BTB
KCTD4 K channel tetramerisation domain containing 4 NP_940686 BTB
KCTD5 K channel tetramerisation domain containing 5 NP_061865 BTB
KCTD6 K channel tetramerisation domain containing 6 NP_699162 BTB
KCTD7 K channel tetramerisation domain containing 7 NP_694578 BTB
KCTD7 potassium channel tetramerisation domain containing 7 NP_694578 BTB
KCTD8 K channel tetramerisation domain containing 8 NP_938167 BTB
KCTD9 K channel tetramerisation domain containing 9 NP_060104 BTB
KDM2A F-box and leucine-rich repeat protein 11 NP_036440 F-box
KDM2B F-box and leucine-rich repeat protein 10 NP_001005366 F-box
KEAP1 kelch-like ECH-associated protein 1 NP_036421 BTB
KLHL1 kelch-like 1 (Drosophila) NP_065917 BTB
KLHL10 kelch-like 10 (Drosophila) NP_689680 BTB
KLHL11 kelch-like 11 (Drosophila) NP_060613 BTB
KLHL12 kelch-like 12 (Drosophila) NP_067646 BTB
KLHL13 kelch-like 13 (Drosophila) NP_277030 BTB
KLHL14 kelch-like 14 (Drosophila) NP_065856 BTB
KLHL15 kelch-like 15 (Drosophila) NP_085127 BTB
KLHL17 kelch-like 17 (Drosophila) NP_938073 BTB
KLHL18 kelch-like 18 (Drosophila) NP_079286 BTB
KLHL20 kelch-like 20 (Drosophila) NP_055273 BTB
KLHL21 kelch-like 21 (Drosophila) NP_055666 BTB
KLHL22 kelch-like 22 (Drosophila) NP_116164 BTB
KLHL23 kelch-like 23 (Drosophila) NP_653312 BTB
KLHL24 kelch-like 24 (Drosophila) NP_060114 BTB
KLHL25 kelch-like 25 (Drosophila) NP_071925 BTB
KLHL26 kelch-like 26 (Drosophila) NP_060786 BTB
KLHL28 kelch-like 28 (Drosophila) NP_060128 BTB
KLHL3 kelch-like 3 (Drosophila) NP_059111 BTB
KLHL30 kelch-like 30 (Drosophila) NP_940984 BTB
KLHL31 kelch-like 31 (Drosophila) NP_001003760 BTB
KLHL32 kelch-like 32 (Drosophila) NP_443136 BTB
KLHL34 kelch-like 34 (Drosophila) NP_695002 BTB
KLHL36 chromosome 16 open reading frame 44 NP_079007 BTB
KLHL38 hypothetical protein LOC340359 NP_001075144 BTB
KLHL4 kelch-like 4 (Drosophila) NP_061990 BTB
KLHL40 kelch repeat and BTB (POZ) domain containing 5 NP_689606 BTB
KLHL41 kelch repeat and BTB (POZ) domain containing 10 NP_006054 BTB
KLHL42 kelch domain containing 5 NP_065833 BTB
KLHL5 kelch-like 5 (Drosophila) NP_001007076 BTB
KLHL6 kelch-like 6 (Drosophila) NP_569713 BTB
KLHL7 kelch-like 7 (Drosophila) NP_001026880 BTB
KLHL8 kelch-like 8 (Drosophila) NP_065854 BTB
KLHL9 kelch-like 9 (Drosophila) NP_061335 BTB
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein NP_005558 BTB
LOC123103 similar to kelch-like 9 XP_063481 BTB
LRRC29 leucine rich repeat containing 29 NP_001004055 F-box
LZTR1 leucine-zipper-like transcription regulator 1 NP_006758 BTB
MGC23270 hypothetical protein MGC23270 NP_689859 BTB
MYNN myoneurin NP_061127 BTB
NACC1 BTB (POZ) domain containing 14B NP_443108 BTB
NACC2 BTB (POZ) domain containing 14A NP_653254 BTB
NEURL2 neuralized homolog 2 (Drosophila) NP_542787 SOCS box
OSTM1 osteopetrosis associated transmembrane protein 1 NP_054747 OSTMP1
OTUD7A OTU domain containing 7A NP_570971 UBA_4
OTUD7B OTU domain containing 7B NP_064590 zf-A20
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 NP_055138 BTB
RAB40A RAB40A, member RAS oncogene family NP_543155 SOCS box
RAB40AL Ras-like GTPase-like NP_001027004 SOCS box
RAB40B RAB40B, member RAS oncogene family NP_006813 SOCS box
RAB40C RAB40C, member RAS oncogene family NP_066991 SOCS box
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 NP_055319 zf-A20
RCBTB1 RCC1 and BTB (POZ) domain containing protein 1 NP_060661 BTB
RCBTB2 RCC1 and BTB (POZ) domain containing protein 2 NP_001259 BTB
RHOBTB1 Rho-related BTB domain containing 1 NP_001027552 BTB
RHOBTB2 Rho-related BTB domain containing 2 NP_055993 BTB
RHOBTB3 Rho-related BTB domain containing 3 NP_055714 BTB
SF3B3 splicing factor 3b, subunit 3, 130kDa NP_036558 CPSF_A
SHKBP1 SH3KBP1 binding protein 1 NP_612401 BTB
SKP2 S-phase kinase-associated protein 2 (p45) NP_005974 F-box
SLX4 BTB (POZ) domain containing 12 NP_115820 BTB
SOCS1 suppressor of cytokine signaling 1 NP_003736 SOCS box
SOCS2 suppressor of cytokine signaling 2 NP_003868 SOCS box
SOCS3 suppressor of cytokine signaling 3 NP_003946 SOCS box
SOCS4 suppressor of cytokine signaling 4 NP_543143 SOCS box
SOCS5 suppressor of cytokine signaling 5 NP_054730 SOCS box
SOCS6 suppressor of cytokine signaling 6 NP_004223 SOCS box
SOCS7 suppressor of cytokine signaling 7 NP_055413 SOCS box
SPOP speckle-type POZ protein NP_001007227 BTB
SPOPL hypothetical protein LOC339745 NP_001001664 BTB
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 NP_079382 SOCS box
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 NP_116030 SOCS box
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 NP_543137 SOCS box
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 NP_543138 SOCS box
TCEB3 transcription elongation factor B (SIII), polypeptide 3 NP_003189 F-box
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) NP_066960 BTB
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 NP_006281 zf-A20
TULP4 tubby like protein 4 NP_001007467 SOCS box
VHL von Hippel-Lindau tumor suppressor NP_000542 SOCS box
WHSC1 Wolf-Hirschhorn syndrome candidate 1 NP_579891 PHD
WSB1 WD repeat and SOCS box-containing 1 NP_056441 SOCS box
WSB2 WD repeat and SOCS box-containing 2 NP_061109 SOCS box
ZBTB1 zinc finger and BTB domain containing 1 NP_055765 BTB
ZBTB10 zinc finger and BTB domain containing 10 NP_076418 BTB
ZBTB11 zinc finger and BTB domain containing 11 NP_055230 BTB
ZBTB14 zinc finger protein 161 homolog (mouse) NP_003400 BTB
ZBTB16 zinc finger and BTB domain containing 16 NP_001018011 BTB
ZBTB17 zinc finger and BTB domain containing 17 NP_003434 BTB
ZBTB18 zinc finger protein 238 NP_006343 BTB
ZBTB2 zinc finger and BTB domain containing 2 NP_065912 BTB
ZBTB20 zinc finger and BTB domain containing 20 NP_056457 BTB
ZBTB21 zinc finger protein 295 NP_001091872 BTB
ZBTB22 zinc finger and BTB domain containing 22 NP_005444 BTB
ZBTB24 zinc finger and BTB domain containing 24 NP_055612 BTB
ZBTB25 zinc finger and BTB domain containing 25 NP_008908 BTB
ZBTB26 zinc finger and BTB domain containing 26 NP_065975 BTB
ZBTB3 zinc finger and BTB domain containing 3 NP_079060 BTB
ZBTB32 zinc finger and BTB domain containing 32 NP_055198 BTB
ZBTB33 zinc finger and BTB domain containing 33 NP_006768 BTB
ZBTB37 zinc finger and BTB domain containing 37 NP_115911 BTB
ZBTB38 zinc finger and BTB domain containing 38 NP_001073881 BTB
ZBTB39 zinc finger and BTB domain containing 39 NP_055645 BTB
ZBTB4 zinc finger and BTB domain containing 4 NP_065950 BTB
ZBTB40 zinc finger and BTB domain containing 40 NP_001077090 BTB
ZBTB41 zinc finger and BTB domain containing 41 NP_919290 BTB
ZBTB43 zinc finger and BTB domain containing 43 NP_054726 BTB
ZBTB44 zinc finger and BTB domain containing 44 NP_054874 BTB
ZBTB45 zinc finger and BTB domain containing 45 NP_116181 BTB
ZBTB46 zinc finger and BTB domain containing 46 NP_079500 BTB
ZBTB48 zinc finger and BTB domain containing 48 NP_005332 BTB
ZBTB49 zinc finger protein 509 NP_660334 BTB
ZBTB5 zinc finger and BTB domain containing 5 NP_055687 BTB
ZBTB6 zinc finger and BTB domain containing 6 NP_006617 BTB
ZBTB7A zinc finger and BTB domain containing 7A NP_056982 BTB
ZBTB7B zinc finger and BTB domain containing 7B NP_056956 BTB
ZBTB7C zinc finger and BTB domain containing 7C NP_001034449 BTB
ZBTB8A zinc finger and BTB domain containing 8 NP_001035531 BTB
ZBTB9 zinc finger and BTB domain containing 9 NP_689948 BTB
ZFAND3 zinc finger, AN1-type domain 3 NP_068762 zf-A20
ZFAND4 AN1, ubiquitin-like, homolog (Xenopus laevis) NP_777550 ZnF_AN1
ZFAND5 zinc finger, AN1-type domain 5 NP_005998 zf-A20
ZFAND6 zinc finger, AN1-type domain 6 NP_061879 zf-A20
ZNF131 zinc finger protein 131 NP_003423 BTB