National Heart, Lung, and Blood Institute

Epithelial Systems Biology Laboratory (ESBL)

Human E3 Ubiquitin Ligases

These ligases can be sorted alphabetically by Gene Symbol, Protein Name, or Class by clicking on the respective header. This information was culled primarily from several existing resources (click to open): Cell Signaling , Inc., hUbiqutome database , Qiagen Ubiquitin Ligases PCR Array , UbiProt Database , DUDE v. 1.0, and Supplemental Table 1 of Li et al . This database was created by Barbara Medvar, Trairak Pisitkun, Abhijit Sarkar, and Mark A. Knepper (Medvar et al.). Please contact Mark Knepper with any comments or questions.

 

Note: No non-catalytic E3 ligase complex components are included in this table. To see the accessory proteins related to E3 ubiquitin ligases click here.

 

Download data as an Excel file

  Gene Symbol

  Protein Name

  Class

  RefSeq

  UniProt No.

RAPSN 43 kDa receptor-associated protein of the synapse isoform 2 RING 38045928 Q13702
AFF4 AF4/FMR2 family member 4 UBOX 7656879 Q9UHB7
ANAPC11 anaphase-promoting complex subunit 11 isoform 2 RING 574957206 Q9NYG5
ANKIB1 ankyrin repeat and IBR domain-containing protein 1 RING 148596953 Q9P2G1
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 HECTc 87116668 O15033
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 IBR 187761373 Q9Y4X5
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 IBR 955471911 O95376
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase RING 21071001 Q9UKV5
BIRC2 baculoviral IAP repeat containing 2 RING 390608639 Q13490
BIRC3 baculoviral IAP repeat containing 3 RING 33946285 Q13489
BIRC7 baculoviral IAP repeat containing 7 RING 21536421 Q96CA5
BIRC8 baculoviral IAP repeat-containing protein 8 RING 44680139 Q96P09
BFAR bifunctional apoptosis regulator RING 7706091 Q9NZS9
BMI1* BMI1 polycomb ring finger proto-oncogene RING 27883842 P35226
BRAP BRCA1 associated protein RING 188497705 Q7Z569
BARD1 BRCA1 associated RING domain 1 RING 543583789 Q99728
BRCA1* breast cancer 1, early onset RING 237681125 P38398
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase RING 54112420 Q13191
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase RING 195927030 Q9ULV8
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase RING 52426745 P22681
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase RING 546230945 Q75N03
CNOT4 CCR4-NOT transcription complex, subunit 4 RING 300069017 O95628
MNAT1 CDK-activating kinase assembly factor MAT1 isoform 2 RING 295789085 P51948
CGRRF1 cell growth regulator with RING finger domain protein 1 RING 5729765 Q99675
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase RING 239048909 Q96EP1
CCDC36 coiled-coil domain-containing protein 36 RING 206597549 Q8IYA8
CUL9 cullin-9 RING 24307991 Q8IWT3
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase RING 116812640 Q9NPC3
CYHR1 cysteine and histidine-rich protein 1 isoform 2 precursor RING 193788637 Q6ZMK1
DZIP3 DAZ interacting zinc finger protein 3 RING 7662244 Q86Y13
DCST1 DC-STAMP domain-containing protein 1 isoform 2 RING 219521926 Q5T197
DTX1 deltex 1, E3 ubiquitin ligase RING 41352718 Q86Y01
DTX2 deltex 2, E3 ubiquitin ligase RING 156564386 Q86UW9
DTX3L deltex 3 like, E3 ubiquitin ligase RING 19923717 Q8TDB6
DTX3 deltex 3, E3 ubiquitin ligase RING 555943736 Q8N9I9
DTX4 deltex 4, E3 ubiquitin ligase RING 663071089 Q9Y2E6
TMEM129 E3 ubiquitin-protein ligase TM129 isoform a RING 187936961 A0AVI4
TRIM4 E3 ubiquitin-protein ligase TRIM4 isoform alpha RING 301601615 Q9C037
TRIM58 E3 ubiquitin-protein ligase TRIM58 RING 112421127 Q8NG06
E4F1 E4F transcription factor 1 zf-C2H2 571026678 Q66K89
FANCL Fanconi anemia, complementation group L RING 167860138 Q9NW38
G2E3 G2/M-phase specific E3 ubiquitin protein ligase HECTc 809279653 Q7L622
HERC2* HECT and RLD domain containing E3 ubiquitin protein ligase 2 HECTc 126032348 O95714
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 HECTc 972781601 Q15034
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 HECTc 499137513 Q5GLZ8
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 HECTc 110825982 Q9UII4
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 HECTc 126131099 Q15751
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 HECTc 259089405 Q8IVU3
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 HECTc 1007360504 Q8IYU2
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 HECTc 612339310 Q9ULT8
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 HECTc 546231434 Q5U5R9
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 HECT 157738609 Q5T447
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 HECTc 359718912 Q9Y4D8
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 HECTc 559098413 Q76N89
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 HECTc 756140743 Q9P2P5
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase HECTc 61676188 Q7Z6Z7
HLTF helicase-like transcription factor RING 21071054 Q14527
KMT2C histone-lysine N-methyltransferase 2C RING 91718902 Q8NEZ4
KMT2D histone-lysine N-methyltransferase 2D RING 148762969 O14686
IRF2BP1 interferon regulatory factor 2 binding protein 1 RING 24308115 Q8IU81
IRF2BP2 interferon regulatory factor 2-binding protein 2 isoform B RING 116734706 Q7Z5L9
IRF2BPL interferon regulatory factor 2-binding protein-like RING 33457336 Q9H1B7
Itch itchy E3 ubiquitin protein ligase HECTc 380420338 Q96J02
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 RING 299758423 Q6UWE0
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase RING 187607085 Q8TBB1
LNX2 ligand of numb-protein X 2 RING 24025688 Q8N448
LTN1 listerin E3 ubiquitin protein ligase 1 RING 1003088782 O94822
LONRF1 LON peptidase N-terminal domain and RING finger protein 1 RING 87080813 Q17RB8
LONRF2 LON peptidase N-terminal domain and RING finger protein 2 RING 148528975 Q1L5Z9
LONRF3 LON peptidase N-terminal domain and RING finger protein 3 isoform 3 RING 574280908 Q496Y0
MAEA macrophage erythroblast attacher isoform 4 RING 661860329 Q7L5Y9
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase RING 334883182 O60291
MKRN1 makorin ring finger protein 1 RING 619329024 Q9UHC7
MKRN2 makorin ring finger protein 2 RING 411147393 Q9H000
MKRN3 makorin ring finger protein 3 RING 5032243 Q13064
MSL2 male-specific lethal 2 homolog (Drosophila) RING 224028284 Q9HC17
Mdm2 MDM2 oncogene, E3 ubiquitin protein ligase RING 510937018 Q00987
MECOM MDS1 and EVI1 complex locus protein EVI1 isoform b RING 327180722 Q03112
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase RING 261823980 Q8TCQ1
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase RING 571026626 Q8NA82
MARCH11 membrane-associated ring finger (C3HC4) 11 RING 156523244 A6NNE9
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase RING 53729334 Q9P0N8
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase RING 30425370 Q86UD3
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase RING 57977325 Q9P2E8
MARCH5 membrane-associated ring finger (C3HC4) 5 RING 8923415 Q9NX47
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase RING 397787554 O60337
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase RING 544346245 Q9H992
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase RING 544583444 Q5T0T0
MARCH9 membrane-associated ring finger (C3HC4) 9 RING 40255016 Q86YJ5
MEX3C mex-3 RNA binding family member C RING 148229134 Q5U5Q3
MID1 midline 1 RING 300797215 O15344
MID2 midline 2 RING 223890259 Q9UJV3
MIB1 mindbomb E3 ubiquitin protein ligase 1 RING 30348954 Q86YT6
MIB2 mindbomb E3 ubiquitin protein ligase 2 RING 282394038 Q96AX9
MUL1* mitochondrial E3 ubiquitin protein ligase 1 RING 171542821 Q969V5
MAP3K1 mitogen-activated protein kinase kinase kinase 1 RING 153945765 Q13233
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase RING 291190787 O75592
MYLIP myosin regulatory light chain interacting protein RING 38788243 Q8WY64
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase HECTc 547235493 P46934
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase HECTc 345478677 Q96PU5
NEURL1 neuralized E3 ubiquitin protein ligase 1 RING 223278368 O76050
NEURL1B neuralized E3 ubiquitin protein ligase 1B RING 815890887 A8MQ27
NEURL3 neuralized E3 ubiquitin protein ligase 3 RING 550822415 Q96EH8
NFXL1 NF-X1-type zinc finger protein NFXL1 RING 520261838 Q6ZNB6
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 RING 40255283 Q6VVB1
NOSIP nitric oxide synthase-interacting protein UBOX 401709927 Q9Y314
NSMCE1* non-SMC element 1 homolog (S. cerevisiae) RING 94721324 Q8WV22
PARK2 parkin RBR E3 ubiquitin protein ligase IBR 169790973 O60260
PDZRN3 PDZ domain containing ring finger 3 RING 735367623 Q9UPQ7
PDZRN4 PDZ domain containing ring finger 4 RING 257196172 Q6ZMN7
PELI1 pellino E3 ubiquitin protein ligase 1 RING-like 11037063 Q96FA3
PELI2 pellino E3 ubiquitin protein ligase family member 2 RING-like 10864063 Q9HAT8
PELI3 pellino E3 ubiquitin protein ligase family member 3 RING-like 341823689 Q8N2H9
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 UBOX 22547215 Q13356
PEX12 peroxisome assembly protein 12 RING 4505721 O00623
PEX10 peroxisome biogenesis factor 10 isoform 1 RING 24797089 O60683
PEX2 peroxisome biogenesis factor 2 RING 289063469 P28328
PHRF1 PHD and RING finger domain-containing protein 1 isoform 1 RING 557440888 Q9P1Y6
PHF7 PHD finger protein 7 isoform 2 RING 506325002 Q9BWX1
PCGF1 polycomb group ring finger 1 RING 109240538 Q9BSM1
PCGF2* polycomb group ring finger 2 RING 6005964 P35227
PCGF3 polycomb group RING finger protein 3 RING 961441521 Q3KNV8
PCGF5 polycomb group RING finger protein 5 RING 380036033 Q86SE9
PCGF6 polycomb group RING finger protein 6 isoform a RING 58761530 Q9BYE7
KCMF1 potassium channel modulatory factor 1 RING 46852178 Q9P0J7
PJA1 praja ring finger 1, E3 ubiquitin protein ligase RING 530421802 Q8NG27
PJA2 praja ring finger 2, E3 ubiquitin protein ligase RING 157412255 O43164
RNF222 PREDICTED: RING finger protein 222 isoform X1 RING 767992469 A6NCQ9
RNF224 PREDICTED: RING finger protein 224 isoform X1 RING 767958041 P0DH78
RNF225 PREDICTED: RING finger protein 225 isoform X1 RING 578834770 M0QZC1
TRIM49C PREDICTED: tripartite motif-containing protein 49C isoform X1 RING 767970497 P0CI26
TRIM49D1 PREDICTED: tripartite motif-containing protein 49D1 isoform X1 RING 767970137 C9J1S8
PRPF19 pre-mRNA processing factor 19 UBOX 7657381 Q9UMS4
RNF212* probable E3 SUMO-protein ligase RNF212 isoform c RING 300863140 Q495C1
PML* promyelocytic leukemia RING 109637788 P29590
MDM4 protein Mdm4 isoform 7 RING 512125239 O15151
RMND5A protein RMD5 homolog A RING 12232469 Q9H871
RMND5B protein RMD5 homolog B isoform a RING 571031354 Q96G75
SCAF11 protein SCAF11 RING 117676384 Q99590
MKRN4P Putative E3 ubiquitin-protein ligase makorin-4 RING 17368441 Q13434
TRIM61 putative tripartite motif-containing protein 61 RING 60099474 Q5EBN2
TRIM64B putative tripartite motif-containing protein 64B RING 256542275 A6NI03
TRIM64C putative tripartite motif-containing protein 64C RING 331028829 A6NLI5
TRIM75P Putative tripartite motif-containing protein 75 RING 187663991 A6NK02
RAD18 RAD18 homolog (S. cerevisiae) RING 256818821 Q9NS91
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 RING 144953898 Q9BYM8
RAG1 recombination activating gene 1 RING 4557841 P15918
RFPL1 ret finger protein-like 1 RING 149408130 O75677
RFPL2 ret finger protein-like 2 isoform 3 RING 227116308 O75678
RFPL3 ret finger protein-like 3 isoform 1 RING 149408135 O75679
RFPL4A ret finger protein-like 4A RING 222446629 A6NLU0
RFPL4AL1 ret finger protein-like 4A-like protein 1 RING 475807831 F8VTS6
RFPL4B ret finger protein-like 4B RING 153791360 Q6ZWI9
RBBP6 retinoblastoma binding protein 6 RING 33620769 Q7Z6E9
RC3H1 ring finger and CCCH-type domains 1 RING 664806085 Q5TC82
RC3H2 ring finger and CCCH-type domains 2 RING 156105699 Q9HBD1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase RING 512749780 Q96PM5
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase RING 62865649 Q8WZ73
RSPRY1 RING finger and SPRY domain-containing protein 1 isoform 1 precursor RING 762205506 Q96DX4
RNFT1 RING finger and transmembrane domain-containing protein 1 RING 109134327 Q5M7Z0
RNFT2 RING finger and transmembrane domain-containing protein 2 isoform 1 RING 158186614 Q96EX2
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase RING 557786192 Q8NHY2
RFWD3 ring finger and WD repeat domain 3 RING 71143112 Q6PCD5
RNF6 ring finger protein (C3H2C3 type) 6 RING 34305295 Q9Y252
RING1* ring finger protein 1 RING 51479192 Q06587
RNF10 ring finger protein 10 RING 34452681 Q8N5U6
RNF103 ring finger protein 103 RING 312147329 O00237
RNF11 ring finger protein 11 RING 7657520 Q9Y3C5
RNF111* ring finger protein 111 RING 395455085 Q6ZNA4
RNF112 RING finger protein 112 RING 264681488 Q9ULX5
RNF113A RING finger protein 113A RING 5902158 O15541
RNF113B RING finger protein 113B RING 30578416 Q8IZP6
RNF114 ring finger protein 114 RING 8923898 Q9Y508
RNF115 ring finger protein 115 RING 530363886 Q9Y4L5
RNF121 RING finger protein 121 isoform b RING 665506028 Q9H920
RNF122 RING finger protein 122 RING 38045931 Q9H9V4
RNF123 ring finger protein 123 RING 37588869 Q5XPI4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase RING 37595555 Q96EQ8
RNF126 ring finger protein 126 RING 37622894 Q9BV68
RNF128 ring finger protein 128, E3 ubiquitin protein ligase RING 37588873 Q8TEB7
RNF13 ring finger protein 13 RING 34577087 O34567
RNF130 ring finger protein 130 RING 526253083 Q86XS8
RNF133 ring finger protein 133 RING 21040269 Q8WVZ7
RNF135 ring finger protein 135 RING 297139721 Q8IUD6
RNF138 ring finger protein 138, E3 ubiquitin protein ligase RING 395455059 Q8WVD3
RNF139 ring finger protein 139 RING 21314654 Q8WU17
RNF14 ring finger protein 14 RING 318067966 Q9UBS8
RNF141 ring finger protein 141 RING 21361493 Q8WVD5
RNF144A ring finger protein 144A RING 38045938 P50876
RNF144B ring finger protein 144B RING 50284696 Q7Z419
RNF145 RING finger protein 145 isoform 5 RING 313661397 Q96MT1
RNF146 ring finger protein 146 RING 338827727 Q9NTX7
RNF148 RING finger protein 148 precursor RING 37675277 Q8N7C7
RNF149 ring finger protein 149 RING 284447287 Q8NC42
RNF150 RING finger protein 150 precursor RING 58331204 Q9ULK6
RNF151 ring finger protein 151 RING 87241872 Q2KHN1
RNF152 ring finger protein 152 RING 27734873 Q8N8N0
RNF157 RING finger protein 157 RING 58743365 Q96PX1
RNF165 RING finger protein 165 isoform 1 RING 57165361 Q6ZSG1
RNF166 RING finger protein 166 isoform 2 RING 284795357 Q96A37
RNF167 ring finger protein 167 RING 14149702 Q9H6Y7
RNF168* ring finger protein 168, E3 ubiquitin protein ligase RING 31377566 Q8IYW5
RNF169 ring finger protein 169 RING 148839382 Q8NCN4
RNF17 RING finger protein 17 isoform 2 RING 297139728 Q9BXT8
RNF170 ring finger protein 170 RING 237858658 Q96K19
RNF175 RING finger protein 175 RING 27734859 Q8N4F7
RNF180 ring finger protein 180 RING 165932346 Q86T96
RNF181 ring finger protein 181 RING 7706039 Q9P0P0
RNF182 ring finger protein 182 RING 259013545 Q8N6D2
RNF183 RING finger protein 183 RING 153252110 Q96D59
RNF185 ring finger protein 185 RING 209529683 Q96GF1
RNF186 RING finger protein 186 RING 9506663 Q9NXI6
RNF187 ring finger protein 187 RING 256225838 Q5TA31
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase RING 525459427 Q9NV58
RNF19B ring finger protein 19B RING 664806060 Q6ZMZ0
RNF2* ring finger protein 2 RING 6005747 Q99496
RNF20 ring finger protein 20, E3 ubiquitin protein ligase RING 34878777 Q5VTR2
RNF207 RING finger protein 207 RING 124487387 Q6ZRF8
RNF208 ring finger protein 208 RING 119220603 Q9H0X6
RNF212B RING finger protein 212B RING 536291168 A8MTL3
RNF213 ring finger protein 213 RING 597709777 Q63HN8
RNF214 RING finger protein 214 isoform 2 RING 503775288 Q8ND24
RNF215 RING finger protein 215 precursor RING 63025220 Q9Y6U7
RNF216 ring finger protein 216 RING 46370057 Q9NWF9
RNF217 ring finger protein 217 RING 556562062 Q8TC41
RNF219 RING finger protein 219 RING 88759348 Q5W0B1
RNF220 ring finger protein 220 RING 46397375 Q5VTB9
RNF223 RING finger protein 223 RING 327412333 E7ERA6
RNF24 RING finger protein 24 isoform 2 RING 197245452 Q9Y225
RNF25 ring finger protein 25 RING 34878787 Q96BH1
RNF26 RING finger protein 26 RING 14042925 Q9BY78
RNF31 ring finger protein 31 RING 109150431 Q96EP0
RNF32 RING finger protein 32 isoform c RING 815729259 Q9H0A6
RNF34 ring finger protein 34, E3 ubiquitin protein ligase RING 378925642 Q969K3
RNF38 ring finger protein 38 RING 37577185 Q9H0F5
RNF39 RING finger protein 39 isoform 1 RING 297206763 Q9H2S5
RNF4* ring finger protein 4 RING 297139779 P78317
RNF40 ring finger protein 40, E3 ubiquitin protein ligase RING 557440901 O75150
RNF41 ring finger protein 41, E3 ubiquitin protein ligase RING 338827618 Q9H4P4
RNF43 ring finger protein 43 RING 770075668 Q68DV7
RNF44 RING finger protein 44 RING 7662486 Q7L0R7
RNF5 ring finger protein 5, E3 ubiquitin protein ligase RING 5902054 Q99942
RNF7** ring finger protein 7 RING 319004144 Q9UBF6
RNF8 ring finger protein 8, E3 ubiquitin protein ligase RING 34304336 O76064
UNK RING finger protein unkempt homolog RING 331028525 Q9C0B0
RLIM ring finger protein, LIM domain interacting RING 34452686 Q9NVW2
RBX1** ring-box 1, E3 ubiquitin protein ligase RING 7657508 P62877
MEX3A RNA-binding protein MEX3A RING 147902746 A1L020
MEX3B RNA-binding protein MEX3B RING 47716512 Q6ZN04
MEX3D RNA-binding protein MEX3D isoform 2 RING 291621664 Q86XN8
SH3RF1 SH3 domain containing ring finger 1 RING 51988887 Q7Z6J0
SH3RF2 SH3 domain containing ring finger 2 RING 222446607 Q8TEC5
SH3RF3 SH3 domain-containing RING finger protein 3 precursor RING 150010572 Q8TEJ3
SIAH1 siah E3 ubiquitin protein ligase 1 RING 63148618 Q8IUQ4
SIAH2 siah E3 ubiquitin protein ligase 2 RING 31982899 O43255
SIAH3 siah E3 ubiquitin protein ligase family member 3 RING 110578665 Q8IW03
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 HECTc 63148618 Q9HCE7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 HECTc 12232397 Q9HAU4
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase RING 289547541 Q149N8
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase UBOX 645912990 Q9UNE7
SYVN1 synovial apoptosis inhibitor 1, synoviolin RING 27436927 Q86TM6
TTC3 tetratricopeptide repeat domain 3 RING 49640011 P53804
TRIP12 thyroid hormone receptor interactor 12 HECTc 545746335 Q14669
TRAF2 TNF receptor-associated factor 2 RING 22027612 Q12933
TRAF3 TNF receptor-associated factor 3 RING 313661483 Q13114
TRAF4 TNF receptor-associated factor 4 RING 22027622 Q9BUZ4
TRAF5 TNF receptor-associated factor 5 RING 77404348 O00463
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase RING 22027630 Q9Y4K3
TRAF7* TNF receptor-associated factor 7, E3 ubiquitin protein ligase RING 45594312 Q6Q0C0
Topors* topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase RING 307344673 Q9NS56
TRAIP TRAF interacting protein RING 40807469 Q9BWF2
NFX1 transcriptional repressor NF-X1 isoform 3 RING 22212927 Q12986
TRIM11 tripartite motif containing 11 RING 21630277 Q96F44
TRIM13 tripartite motif containing 13 RING 55953112 O60858
TRIM17 tripartite motif containing 17 RING 198442878 Q9Y577
TRIM2 tripartite motif containing 2 RING 705044345 Q9C040
TRIM21 tripartite motif containing 21 RING 15208660 P19474
TRIM22 tripartite motif containing 22 RING 313760629 Q8IYM9
TRIM23 tripartite motif containing 23 RING 15208643 P36406
TRIM24 tripartite motif containing 24 RING 47419911 O15164
TRIM25 tripartite motif containing 25 RING 68160937 Q14258
TRIM27 tripartite motif containing 27 RING 5730009 P14373
TRIM28* tripartite motif containing 28 RING 5032179 Q123263
TRIM31 tripartite motif containing 31 RING 62865604 Q9BZY9
TRIM32 tripartite motif containing 32 RING 153792582 Q13049
TRIM33 tripartite motif containing 33 RING 74027251 Q9UPN9
TRIM36 tripartite motif containing 36 RING 663429604 Q9NQ86
TRIM37 tripartite motif containing 37 RING 52487176 O94972
TRIM38 tripartite motif containing 38 RING 5454014 O00635
TRIM39 tripartite motif containing 39 RING 25777698 Q9HCM9
TRIM41 tripartite motif containing 41 RING 42516574 Q8WV44
TRIM5 tripartite motif containing 5 RING 283046698 Q9C035
TRIM50 tripartite motif containing 50 RING 527122124 Q86XT4
TRIM56 tripartite motif containing 56 RING 30794216 Q9BRZ2
TRIM59 tripartite motif containing 59 RING 27436877 Q8IWR1
TRIM62 tripartite motif containing 62 RING 217035095 Q9BVG3
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase RING 19924163 Q969Q1
TRIM67 tripartite motif containing 67 RING 134288906 Q6ZTA4
TRIM68 tripartite motif containing 68 RING 751557653 Q6AZZ1
TRIM69 tripartite motif containing 69 RING 667478204 Q86WT6
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase RING 84993742 Q2Q1W2
TRIM8 tripartite motif containing 8 RING 148596968 Q9BZR9
TRIM9 tripartite motif containing 9 RING 190341104 Q9C026
TRIML1 tripartite motif family-like 1 RING 31542779 Q8N9V2
TRIML2 tripartite motif family-like 2 SPRY 742068547 Q8N7C3
TRIM49B tripartite motif-containing protein RING 331028811 A6NDI0
TRIM10 tripartite motif-containing protein 10 isoform 1 RING 157426898 Q9UDY6
TRIM15 tripartite motif-containing protein 15 RING 149193331 Q9C019
TRIM26 tripartite motif-containing protein 26 RING 338753391 Q12899
TRIM3 tripartite motif-containing protein 3 isoform 2 RING 351721595 O75382
TRIM34 tripartite motif-containing protein 34 isoform 3 RING 145275183 Q9BYJ4
TRIM35 tripartite motif-containing protein 35 isoform 2 RING 751368110 Q9UPQ4
TRIM40** tripartite motif-containing protein 40 isoform a RING 557636691 Q6P9F5
TRIM42 tripartite motif-containing protein 42 RING 301500637 Q8IWZ5
TRIM43 tripartite motif-containing protein 43 RING 20270353 Q96BQ3
TRIM43B tripartite motif-containing protein 43B RING 256600212 A6NCK2
TRIM45 tripartite motif-containing protein 45 isoform 2 RING 224548923 Q9H8W5
TRIM46 tripartite motif-containing protein 46 isoform 6 RING 538260579 Q7Z4K8
TRIM47 tripartite motif-containing protein 47 RING 54792146 Q96LD4
TRIM48 tripartite motif-containing protein 48 RING 201862060 Q8IWZ4
TRIM49 tripartite motif-containing protein 49 RING 9966829 P0CI25
TRIM51 tripartite motif-containing protein 51 RING 209862805 Q9BSJ1
TRIM52 tripartite motif-containing protein 52 RING 14249412 Q96A61
TRIM54 tripartite motif-containing protein 54 isoform 1 RING 78482627 Q9BYV2
TRIM55 tripartite motif-containing protein 55 isoform 4 RING 34878852 Q9BYV6
TRIM6 tripartite motif-containing protein 6 isoform 3 RING 310772223 Q9C030
TRIM60 tripartite motif-containing protein 60 RING 384475510 Q495X7
TRIM64 tripartite motif-containing protein 64 RING 210147600 A6NGJ6
TRIM65 tripartite motif-containing protein 65 isoform 2 RING 371122551 Q6PJ69
TRIM7 tripartite motif-containing protein 7 isoform 2 RING 44680130 Q9C029
TRIM72 tripartite motif-containing protein 72 RING 270265876 Q6ZMU5
TRIM73 tripartite motif-containing protein 73 RING 65285121 Q86UV7
TRIM74 tripartite motif-containing protein 74 RING 38524612 Q86UV6
TRIM77 tripartite motif-containing protein 77 isoform 2 RING 429836863 I1YAP6
UBR1 ubiquitin protein ligase E3 component n-recognin 1 UBR 28372497 Q8IWV7
UBR2 ubiquitin protein ligase E3 component n-recognin 2 UBR 296317280 Q8IWV8
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) UBR 160948610 Q6ZT12
UBR4 ubiquitin protein ligase E3 component n-recognin 4 UBR 82659109 Q5T4S7
UBR5 ubiquitin protein ligase E3 component n-recognin 5 HECTc 544583486 O95071
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) UBR 154426322 Q8N806
UBE3A ubiquitin protein ligase E3A HECTc 19718766 Q05086
UBE3B ubiquitin protein ligase E3B HECTc 394025737 Q7Z3V4
UBE3C ubiquitin protein ligase E3C HECTc 187960100 Q15386
UBE3D ubiquitin protein ligase E3D HECT_2 750321479 Q7Z6J8
UBE4A ubiquitination factor E4A RING 323362983 Q14139
UBE4B ubiquitination factor E4B RING 157739864 O95155
UHRF1 ubiquitin-like with PHD and ring finger domains 1 RING 586798166 Q96T88
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase RING 23312364 Q96PU4
UBOX5 U-box domain containing 5 RING 389886556 O94941
UNKL unkempt family zinc finger-like RING 448824848 Q9H9P5
VPS11 vacuolar protein sorting-associated protein 11 homolog isoform 2 RING 589058161 Q9H270
VPS18 vacuolar protein sorting-associated protein 18 homolog RING 17978485 Q9P253
VPS41 vacuolar protein sorting-associated protein 41 homolog isoform 1 RING 114199475 P49754
VPS8 vacuolar protein sorting-associated protein 8 homolog isoform a RING 57863277 Q8N3P4
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 RING 808175923 Q8N9V3
WDR59 WD repeat-containing protein 59 RING 58331266 Q6PJI9
WWP1 WW domain containing E3 ubiquitin protein ligase 1 HECTc 13654239 Q9H0M0
WWP2 WW domain containing E3 ubiquitin protein ligase 2 HECTc 394581985 O00308
XIAP X-linked inhibitor of apoptosis RING 324711009 P98170
ZFP91 ZFP91 zinc finger protein zf-C2H2 308081964 Q96JP5
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase RING 14150005 Q8ND25
ZNRF2 zinc and ring finger 2 RING 23821044 Q8NHG8
ZNRF3 zinc and ring finger 3 RING 332801080 Q9ULT6
ZNRF4 zinc and ring finger 4 RING 150170725 Q8WWF5
ZBTB12 zinc finger and BTB domain-containing protein 12 RING 32469509 Q9Y330
ZNF280A zinc finger protein 280A HECT 618857456 P59817
ZNF341 zinc finger protein 341 isoform 3 RING 544711270 Q9BYN7
ZNF511 zinc finger protein 511 RING 28274701 Q8NB15
ZNF521 zinc finger protein 521 isoform 2 RING 815891044 Q96K83
ZNF598 zinc finger protein 598 RING 409264581 Q86UK7
ZNF645 zinc finger protein 645 RING 22749189 Q8N7E2
PLAG1 zinc finger protein PLAG1 isoform b RING 167857798 Q6DJT9
PLAGL1 zinc finger protein PLAGL1 isoform 1 RING 573459768 Q9UM63
RLF zinc finger protein Rlf RING 157671949 Q13129
ZXDC zinc finger protein ZXDC isoform 2 RING 98961138 Q2QGD7
ZFPL1 zinc finger protein-like 1 RING 33300635 O95159
Zswim2 zinc finger, SWIM-type containing 2 RING 71043932 Q8NEG5

    * Proteins also show SUMO ligase activity

    ** Proteins also show neddylation activity