Epithelial Systems Biology Laboratory
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 Home Page Research Water Balance
Disorders
Vasopressin and its
Receptors
Aquaporins Systems Biology Protein Mass
Spectrometry
Phosphoproteomics Deep Sequencing
in Epithelia
Bioinformatic/
Computational Tools
Proteomics &
Transcriptomics Databases
Integrated Antibody Design Kidney Systems Biology Project Isolated Perfused
Tubule
AbDesigner

The Epithelial Systems Biology Laboratory, headed by Mark Knepper, uses systems biology-based approaches to study how the kidney regulates water excretion. This involves use of large-scale data acquisition techniques, such as protein mass spectrometry and ‘next-generation’ nucleotide sequencing technologies to discover molecular mechanisms involved in renal water transport. Much of the focus is on regulation of molecular water channels called aquaporins by the hormone vasopressin. The Epithelial Systems Biology Laboratory is a small close-knit group of scientists devoted to development and exploitation of cutting-edge experimental and computational tools for these studies.

Water Balance Disorders
Water Balance Disorders
Vasopressin
Vasopressin and its Receptors
Aquaporins
Aquaporins
Systems Biology
Systems Biology
Quantitative MS
Protein Mass Spectrometry
Phosphoproteomics
Phosphoproteomics
Systems Biology
Deep Sequencing in Epithelia
Quantitative MS
ESBL Bioinformatics/
Computational Tools
Databases
Proteomics &
Transcriptomics Databases
Antibody Design
Integrated Antibody Design
Proteomic/Transcriptomic Databases
Kidney Systems Biology Project
Proteomic/Transcriptomic Databases
Isolated Perfused Tubule